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Evaluation of a new commercial automated planning software for tangential breast intensity-modulated radiation therapy

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Abstract

Automated treatment planning may decrease the effort required in planning and promote increased routine clinical use of intensity-modulated radiation therapy (IMRT) for many breast cancer patients. The aim of this study was to evaluate a new commercial automated planning software for tangential breast IMRT by comparing it with clinical plans from whole-breast irradiation. We prospectively enrolled 150 patients with Stage 0–1 breast cancer who underwent breast-conserving surgery at our institution between September 2016 and August 2017. Total doses of 42.56 Gy in 16 fractions (n = 98) or 50 Gy in 25 fractions (n = 44) were used. All treatment plans were retrospectively re-planned using the automated breast planning (ABP) software. All automated plans generated clinically deliverable beam parameters with no patient body collision and no contralateral breast pass through. The mean homogeneity index of the automatically generated clinical target volume, percentage volume of lungs receiving dose more than 20 Gy, mean heart dose, and dose to the highest irradiated 2-cc volumes of the irradiated volume were 0.077 ± 0.019, 4.2% ± 1.2%, 142 ± 69 cGy, and 105.8% ± 1.7% (prescribed dose: 100%), respectively. The mean planning time was 4.8 ± 1.4 min. The ABP software demonstrated high clinical acceptability and treatment planning cost efficiency for tangential breast IMRT. The ABP software may be useful for delivering high-quality treatment to a majority of patients with early-stage breast cancer.

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Acknowledgements

Some of the findings reported here were presented at The 30th Annual Meeting of the Japanese Society for Radiation Oncology in Osaka-shi, Osaka-fu, Japan, held November 17–19, 2017.

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Authors and Affiliations

  1. Department of Radiation Oncology, St. Luke’s International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan

    Norifumi Mizuno, Ryouhei Yamauchi, Jiro Kawamori, Tomoko Itazawa & Shogo Hatanaka

  2. Department of Radiation Oncology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe City, Saitama, 350-8550, Japan

    Norifumi Mizuno, Munefumi Shimbo, Keiichiro Nishimura, Takafumi Yamano, Shogo Hatanaka, Masatsugu Hariu & Takeo Takahashi

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  1. Norifumi Mizuno
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  2. Ryouhei Yamauchi
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Correspondence to Norifumi Mizuno.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional review board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Mizuno, N., Yamauchi, R., Kawamori, J. et al. Evaluation of a new commercial automated planning software for tangential breast intensity-modulated radiation therapy. Radiol Phys Technol 12, 249–259 (2019). https://doi.org/10.1007/s12194-019-00515-9

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  • DOI: https://doi.org/10.1007/s12194-019-00515-9

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