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IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations

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Abstract

Genetic variation in immune-related genes, such as IL10 and TNF, have been associated with the development of non-Hodgkin lymphoma (NHL) in Caucasian populations. To test the hypothesis that IL10 and TNF polymorphisms may be associated with NHL risk in Asian populations, we genotyped 20 single nucleotide polymorphisms (SNPs) within the IL10 and TNF/LTA loci in three independent case–control studies (2635 cases and 4234 controls). IL10 rs1800871, rs1800872, and rs1800896 were genotyped in all three studies, while 5 of the remaining SNPs were genotyped in two studies, and 12 in a single study. IL10 rs1800896 was associated with B cell lymphoma [per-allele odds ratio (OR) = 1.25, 95 % confidence interval (CI) 1.08–1.45; p trend = 0.003], specifically diffuse large B cell lymphoma (DLBCL) (per-allele OR = 1.29, 95 % CI 1.08–1.53; p trend = 0.004), as well as T cell lymphoma (per-allele OR = 1.44, 95 % CI 1.13–1.82; p trend = 0.003). TNF rs1800629, which was genotyped in only two of our studies, was also associated with B cell lymphoma (per-allele OR = 0.77, 95 % CI 0.64–0.91; p trend = 0.003), specifically DLBCL (per-allele OR = 0.69, 95 % CI 0.55–0.86; p trend = 0.001). Our findings suggest that genetic variation in IL10 and TNF may also play a role in lymphomagenesis in Asian populations.

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Acknowledgments

This work was supported by the Intramural Research Program of the National Institutes of Health (NIH) [National Cancer Institute (NCI)], by Science Technology of Shandong Province grants ZR2009CM093 and 2011GSF11820, and by a grant from the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A01-0385-A70604-07M7-00000A).

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Author information

Authors and Affiliations

  1. Division of Cancer Epidemiology and Genetics, NCI, NIH, DHHS, Bethesda, MD, USA

    H. Dean Hosgood III, Wei Hu, Stephen J. Chanock, Mark P. Purdue, Nathaniel Rothman & Qing Lan

  2. Division of Epidemiology, Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Ave., Belfer 1309, Bronx, NY, 10461, USA

    H. Dean Hosgood III

  3. Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, Hong Kong

    Wing-Yan Au, Jovic Tse & Raymond Liang

  4. Genome Research Center for Hematopoietic Diseases, Chonnam National University Hwasun Hospital, Hwasun, Jeollanam-do, South Korea

    Hee Nam Kim & Hyeoung-Joon Kim

  5. Key Laboratory of Radiation Oncology of Shandong Province, Shandong Cancer Hospital and Institute, Jinan, Shandong, China

    Jie Liu, Bao Song & Jinming Yu

  6. Department of Pathology, Queen Elizabeth Hospital, Hong Kong, Hong Kong

    Kit-fai Wong & L. P. Siu

  7. Department of Hematology/Oncology, Research Institute of Medical Sciences, Chonnam National University Medical School, Gwangju, South Korea

    Je-Jung Lee & Hyeoung-Joon Kim

  8. Department of Preventive Medicine, Chonnam National University Medical School, Gwangju, South Korea

    Min-ho Shin

Authors
  1. H. Dean Hosgood III
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  2. Wing-Yan Au
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  3. Hee Nam Kim
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  4. Jie Liu
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  5. Wei Hu
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  6. Jovic Tse
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  7. Bao Song
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  8. Kit-fai Wong
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  9. Je-Jung Lee
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  10. Stephen J. Chanock
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  11. L. P. Siu
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  12. Mark P. Purdue
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  13. Min-ho Shin
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  14. Jinming Yu
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  15. Raymond Liang
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  16. Hyeoung-Joon Kim
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  17. Nathaniel Rothman
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  18. Qing Lan
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Corresponding author

Correspondence to H. Dean Hosgood III.

Additional information

H. D. Hosgood III, W.-Y. Au, H. N. Kim, and J. Liu contributed equally. J. Yu, R. Liang, H.-J. Kim, N. Rothman, and Q. Lan contributed equally.

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Hosgood, H.D., Au, WY., Kim, H.N. et al. IL10 and TNF variants and risk of non-Hodgkin lymphoma among three Asian populations. Int J Hematol 97, 793–799 (2013). https://doi.org/10.1007/s12185-013-1345-5

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  • DOI: https://doi.org/10.1007/s12185-013-1345-5

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