Skip to main content

Advertisement

SpringerLink
Log in

Therapy related CMML: a case report and review of the literature

  • Case Report
  • Published:
International Journal of Hematology Aims and scope Submit manuscript

Abstract

Therapy related chronic myelomonocytic leukemia (t-CMML) is rare. We report a 23-year-old female who developed acute fulminant hepatic failure after drug overdose. She underwent ABO incompatible orthotopic liver transplant. She received cyclophosphamide along with other immunosuppressants. Seven years later, she was diagnosed with t-CMML-2 with 45XX,-7 karyotype. She received 4 cycles of azacitidine and proceeded with allogeneic bone marrow transplant. This is the first a case of t-CMML reported in a liver transplant recipient. In this article, we also summarize all reported cases of t-CMML, and we review therapy related MDS in recipients of solid organ transplant.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Bennett JM, Komrokji R, Kouides P. The myelodysplastic syndromes. In: Abeloff MD, Armitage JO, Niederhuber JE, editors. Clinical oncology, vol. 3rd. New York: Churchill Livingstone; 2004. p. 2849–81.

    Google Scholar 

  2. Pedersen-Bjergaard J, Philip P. Two different classes of therapy-related and de novo acute myeloid leukemia? Cancer Genet Cytogenet. 1991;55:119–24. doi:10.1016/0165-4608(91)90246-Q.

    Article  PubMed  CAS  Google Scholar 

  3. Harris NL, Jaffe ES, Diebold J, et al. World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee meeting, Airlie House, Virginia, November 1997. J Clin Oncol. 1999;17(12):3835–49.

    Google Scholar 

  4. Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the acute leukaemias. French–American–British (FAB) co-operative group. Br J Haematol. 1976;33:451–8. doi:10.1111/j.1365-2141.1976.tb03563.x.

    Article  PubMed  CAS  Google Scholar 

  5. Bennett JM, Catovsky D, Daniel MT, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189–99.

    PubMed  CAS  Google Scholar 

  6. Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. Blood. 2002;100:2292–302. doi:10.1182/blood-2002-04-1199.

    Article  PubMed  CAS  Google Scholar 

  7. Komrokji RS, Bennett JM. The clinical implications of the World Health Organization’s classification of myelodysplastic syndromes. Curr Hematol Rep. 2005;4:175–81.

    PubMed  Google Scholar 

  8. Knipp S, Hildebrandt B, Richter J, Haas R, Germing U, Gattermann N. Secondary myelodysplastic syndromes following treatment with azathioprine are associated with aberrations of chromosome 7. Haematologica. 2005;90:691–3.

    PubMed  Google Scholar 

  9. Ueki K, Sato S, Tamura J, et al. Three cases of multiple myeloma developing into melphalan-related chronic myelomonocytic leukemia. J Med. 1991;22:157–61.

    PubMed  CAS  Google Scholar 

  10. Oo TH, Kenney L. Therapy-related chronic myelomonocytic leukemia with unique chromosomal abnormalities: monosomy 7 and t(12;17)(p13;q11.2). Am J Hematol. 2007;82:248–9. doi:10.1002/ajh.20730.

    Article  PubMed  Google Scholar 

  11. Kim KB, Faderl S, Hwang CS, Khuri FR. Chronic myelomonocytic leukaemia after platinum-based therapy for non-small cell lung cancer: case report and review of the literature. J Clin Pharm Ther. 2006;31:401–6. doi:10.1111/j.1365-2710.2006.00748.x.

    Article  PubMed  CAS  Google Scholar 

  12. Muroi K, Miyata T, Saito M, Hatake K, Amemiya Y, Miura Y. Therapy-related chronic myelomonocytic leukaemia with bone marrow eosinophilia associated with der(11)t(1;11)(q21;q14). Acta Haematol. 1996;96:251–4. doi:10.1159/000203795.

    Article  PubMed  CAS  Google Scholar 

  13. Hanto DW, Fecteau AH, Alonso MH, Valente JF, Whiting JF. ABO-incompatible liver transplantation with no immunological graft losses using total plasma exchange, splenectomy, and quadruple immunosuppression: evidence for accommodation. Liver Transpl. 2003;9:22–30. doi:10.1053/jlts.2003.50011.

    Article  PubMed  Google Scholar 

  14. Renard TH, Andrews WS. An approach to ABO-incompatible liver transplantation in children. Transplantation. 1992;53:116–21. doi:10.1097/00007890-199201000-00022.

    Article  PubMed  CAS  Google Scholar 

  15. Penn I. Leukemia in the immunosuppressed organ recipient. Ann Thorac Surg. 1994;57:216.

    Article  Google Scholar 

  16. Huebner G, Karthaus M, Pethig K, Freund M, Ganser A. Myelodysplastic syndrome and acute myelogenous leukemia secondary to heart transplantation. Transplantation. 2000;70:688–90. doi:10.1097/00007890-200008270-00026.

    Article  PubMed  CAS  Google Scholar 

  17. Kobbe G, Germing U, Aivado M, et al. Treatment of secondary myelodysplastic syndrome after heart transplantation with chemotherapy and nonmyeloablative stem-cell transplantation. Transplantation. 2002;74:1198–200. doi:10.1097/00007890-200210270-00027.

    Article  PubMed  Google Scholar 

  18. Offman J, Opelz G, Doehler B, et al. Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantation. Blood. 2004;104:822–8. doi:10.1182/blood-2003-11-3938.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Hematology and Medical Oncology Division, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA

    Faheem Ahmed & Nadia Osman

  2. Department of Pathology, University of Cincinnati, Cincinnati, OH, USA

    Fred Lucas

  3. Digestive Disease Division, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA

    Guy Neff

  4. Division of Human Genetics, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA

    Teresa Smolarek

  5. Department of Medicine, The James P. Wilmot Cancer Center, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA

    John M. Bennett

  6. Department of Oncologic Sciences, University of South Florida, Tampa, FL, 33612, USA

    Rami S. Komrokji

  7. Department of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, FOB 3rd floor, 12902 Magnolia Drive, Tampa, FL, 33612, USA

    Rami S. Komrokji

Authors
  1. Faheem Ahmed
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nadia Osman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fred Lucas
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Guy Neff
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Teresa Smolarek
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. John M. Bennett
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Rami S. Komrokji
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Rami S. Komrokji.

About this article

Cite this article

Ahmed, F., Osman, N., Lucas, F. et al. Therapy related CMML: a case report and review of the literature. Int J Hematol 89, 699–703 (2009). https://doi.org/10.1007/s12185-009-0318-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12185-009-0318-1

Keywords

Search

Navigation