Skip to main content

Advertisement

SpringerLink
Log in

Mammary Lobular Carcinoma-Like Salivary Gland Carcinoma: Report of a Rare Case

  • Case Reports
  • Published:
Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Salivary and mammary glands are both exocrine organs sharing multiple tumorigenic processes. To the best of our knowledge, salivary gland tumors mimicking invasive lobular carcinoma of the breast have not yet been described. Herein, we report a case of a 62-year-old male who presented with progressive facial paralysis. Pathologic examination revealed an ill-defined epithelial neoplasm exhibiting discohesive growth set within an extensively fibrotic stroma. Both perineural and intraneural invasion were present. E-cadherin and p120 immunostaining showed aberrant cytoplasmic expression. Targeted next-generation sequencing detected a frameshift mutation of the CTNNA1 gene as the only known pathogenic variant. The patient was treated with surgical resection, immunotherapy, and chemotherapy. Currently, he is alive with disease twenty months after disease onset.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Kusafuka K, Onitsuka T, Muramatsu K, Miki T, Murai C, Suda T, et al. Salivary duct carcinoma with rhabdoid features: report of 2 cases with immunohistochemical and ultrastructural analyses. Head Neck. 2014;36:E28–35.

    Article  PubMed  Google Scholar 

  2. Kusafuka K, Kawasaki T, Maeda M, Yamanegi K, Baba S, Ito Y, et al. Salivary duct carcinoma with rhabdoid features: a salivary counterpart of pleomorphic lobular carcinoma of the breast. Histopathology. 2017;70:164–73.

    Article  PubMed  Google Scholar 

  3. Kusafuka K, Yamada H, Ishino K, Maeda M, Yamanegi K, Baba S, et al. Salivary duct carcinoma with rhabdoid features-No or aberrant expression of E-cadherin and genetic changes in CDH1: Immunohistochemical and genetic analyses of 17 cases. Am J Surg Pathol. 2021;45:439–49.

    Article  PubMed  Google Scholar 

  4. Dalin MG, Desrichard A, Katabi N, Makarov V, Walsh LA, Lee KW, et al. Comprehensive molecular characterization of salivary duct carcinoma reveals actionable targets and similarity to apocrine breast cancer. Clin Cancer Res. 2016;22:4623–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Chiosea SI, Thompson LD, Weinreb I, Bauman JE, Mahaffey AM, Miller C, et al. Subsets of salivary duct carcinoma defined by morphologic evidence of pleomorphic adenoma, PLAG1 or HMGA2 rearrangements, and common genetic alterations. Cancer. 2016;122:3136–44.

    Article  CAS  PubMed  Google Scholar 

  6. Murzabdillaeva A, Ali Y, Aakash N, Armstrong J, Ghorbani R, Zhang S. Pleomorphic invasive lobular carcinoma of the male breast: two case reports with opposite hormone receptor status. Ann Clin Lab Sci. 2019;49:534–8.

    PubMed  Google Scholar 

  7. Ito Y, Ishida M, Ohe C, Miyasaka C, Tsuta K. Signet-ring cell/histiocytoid carcinoma in the axilla: A case report with genetic analysis using next-generation sequencing. J Cutan Pathol. 2021;48:102–5.

    Article  PubMed  Google Scholar 

  8. Krishnamurthy J, Krishnamurty D, Baker J, Zhen W, Lydiatt D, Ganti A. Salivary duct carcinoma responding to trastuzumab-based therapy: case report and review of the literature. Head Neck. 2013;35:E372–5.

    Article  PubMed  Google Scholar 

  9. Oo A, Yamaguchi S, Iwaki H, Amagasa T. Axillary nodal metastasis from oral and maxillofacial cancers: a report of 3 cases. J Oral Maxillofac Surg. 2004;62:1019–24.

    Article  PubMed  Google Scholar 

  10. Hafez M, Refky B, Elwahab K, Arafa M, Abdou I, Elnahas W. Axillary lymph nodes metastasis in a patient with recurrent papillary thyroid cancer: a case report. J Med Case Rep. 2015;9:181.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Akaki M, Ishihara A, Nagai K, Naono H, Taguchi K, Yamamoto H, et al. Signet ring cell differentiation in salivary duct carcinoma with rhabdoid features: report of three cases and literature review. Head Neck Pathol. 2020 https://doi.org/10.1007/s12105-020-01186-4.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Wilson TR, Udyavar AR, Chang CW, Spoerke JM, Aimi J, Savage HM, et al. Genomic alterations associated with recurrence and TNBC subtype in high-risk early breast cancers. Mol Cancer Res. 2019;17:97–108.

  13. Majewski IJ, Kluijt I, Cats A, et al. An alpha-E-catenin (CTNNA1) mutation in hereditary diffuse gastric cancer. J Pathol. 2013;229:621–9.

    Article  CAS  PubMed  Google Scholar 

  14. Clark DF, Michalski ST, Tondon R, Nehoray B, Ebrahimzadeh J, Hughes SK, et al. Loss-of-function variants in CTNNA1 detected on multigene panel testing in individuals with gastric or breast cancer. Genet Med. 2020;22:840–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Al-Hussain T, Haffner MC, Altaweel WM, Epstein JI. Plasmacytoid acinar adenocarcinoma of the prostate: a newly described variant of prostate cancer. Hum Pathol. 2019;94:86–91.

    Article  CAS  PubMed  Google Scholar 

  16. de Groot JS, Ratze MA, van Amersfoort M, Eisemann T, Vlug EJ, Niklaas MT, et al. alphaE-catenin is a candidate tumor suppressor for the development of E-cadherin-expressing lobular-type breast cancer. J Pathol. 2018;245:456–67.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Blair VR, McLeod M, Carneiro F, Coit DG, D’Addario JL, van Dieren JM, et al. Hereditary diffuse gastric cancer: updated clinical practice guidelines. Lancet Oncol. 2020;21:e386–e397

  18. Ross JS, Gay LM, Wang K, Vergilio JA, Suh J, Ramkissoon S, et al. Comprehensive genomic profiles of metastatic and relapsed salivary gland carcinomas are associated with tumor type and reveal new routes to targeted therapies. Ann Oncol. 2017;28:2539–46.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Sasaki E, Masago K, Fujita S, Suzuki H, Hanai N, Hosoda W. Salivary secretory carcinoma harboring a novel ALK fusion: expanding the molecular characterization of carcinomas beyond the ETV6 gene. Am J Surg Pathol. 2020;44:962–9.

    Article  PubMed  Google Scholar 

  20. Syrigos K, Harrington K, Waxman J, Krausz T, Pignatelli M. Altered gamma-catenin expression correlates with poor survival in patients with bladder cancer. J Urol. 1998;160:1889–93.

    Article  CAS  PubMed  Google Scholar 

  21. Balatskyi VV, Macewicz LL, Gan AM, Goncharov SV, Pawelec P, Portnichenko GV, et al. Cardiospecific deletion of alphaE-catenin leads to heart failure and lethality in mice. Pflugers Arch. 2018;470:1485–99.

    Article  CAS  PubMed  Google Scholar 

  22. Perrino CM, Eble J, Kao CS, Whaley RD, Cheng L, Idrees M, et al. Plasmacytoid/diffuse urothelial carcinoma: a single-institution immunohistochemical and molecular study of 69 patients. Hum Pathol. 2019;90:27–36.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

The authors would like to thank Norman L Cyr for his expertise in figure illustration.

Funding

No funding obtained.

Author information

Authors and Affiliations

  1. Department of Pathology, Stanford University Medical Center, Palo Alto, USA

    Li Lei, Megan Troxell, Michael G. Ozawa & Gerald Berry

  2. Department of Radiology, Stanford University Medical Center, Palo Alto, USA

    Eric Van Staalduinen & Michael Zeineh

  3. Department of Pathology, Stanford Health Care, 300 Pasteur Dr, CA, 94304, Palo Alto, USA

    Li Lei

Authors
  1. Li Lei
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eric Van Staalduinen
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Megan Troxell
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Michael G. Ozawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Michael Zeineh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Gerald Berry
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

All authors contributed to the study conception. Material preparation, pathology data collection and interpretation were performed by Li Lei. Radiology data collection and interpretation were performed by Eric Van Staalduinen and Michael Zeineh. The first draft of the manuscript was written by Li Lei and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Li Lei.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest, either financial or non-financial.

Ethical Approval

This study was approved by Stanford University Institutional Review Board.

Informed Consent

All data have been de-identified.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lei, L., Van Staalduinen, E., Troxell, M. et al. Mammary Lobular Carcinoma-Like Salivary Gland Carcinoma: Report of a Rare Case. Head and Neck Pathol 16, 314–321 (2022). https://doi.org/10.1007/s12105-021-01344-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12105-021-01344-2

Keywords

Search

Navigation