Skip to main content

Advertisement

Log in

Mammary Analogue Secretory Carcinoma Mimicking Salivary Adenoma

  • Original Paper
  • Published:
Head and Neck Pathology Aims and scope Submit manuscript

Abstract

Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumor characterized by ETV6 translocation. It appears that prior studies have identified MASC by reviewing salivary gland carcinomas, such as acinic cell carcinoma and adenocarcinoma, not otherwise specified. To address the possibility of MASC mimicking benign salivary neoplasms we reviewed 12 salivary gland (cyst)adenomas diagnosed prior to the discovery of MASC. One encapsulated (cyst)adenoma of the parotid gland demonstrated features of MASC. The diagnosis was confirmed by fluorescence in situ hybridization with an ETV6 break-apart probe. An unusual complex pattern of ETV6 rearrangement with duplication of the telomeric/distal ETV6 probe was identified. This case illustrates that MASC may mimic salivary (cyst)adenomas. To more accurately assess true clinical and morphologic spectrum of MASC, future studies may have to include review of salivary (cyst)adenomas. The differential diagnosis of MASC may have to be expanded to include cases resembling salivary (cyst)adenomas.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Skalova A, Vanecek T, Sima R, Laco J, Weinreb I, Perez-Ordonez B, et al. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol. 2010;34(5):599–608. doi:10.1097/PAS.0b013e3181d9efcc.

    PubMed  Google Scholar 

  2. Kratochvil FJ 3rd, Stewart JC, Moore SR. Mammary analog secretory carcinoma of salivary glands: a report of 2 cases in the lips. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114(5):630–5. doi:10.1016/j.oooo.2012.07.480.

    Article  PubMed  Google Scholar 

  3. Chiosea SI, Griffith C, Assaad A, Seethala RR. Clinicopathological characterization of mammary analogue secretory carcinoma of salivary glands. Histopathology. 2012;61(3):387–94. doi:10.1111/j.1365-2559.2012.04232.x.

    Article  PubMed  Google Scholar 

  4. Connor A, Perez-Ordonez B, Shago M, Skalova A, Weinreb I. Mammary analog secretory carcinoma of salivary gland origin with the ETV6 gene rearrangement by FISH: expanded morphologic and immunohistochemical spectrum of a recently described entity. Am J Surg Pathol. 2012;36(1):27–34. doi:10.1097/PAS.0b013e318231542a.

    Article  PubMed  Google Scholar 

  5. Fehr A, Loning T, Stenman G. Mammary analogue secretory carcinoma of the salivary glands with ETV6-NTRK3 gene fusion. Am J Surg Pathol. 2011;35(10):1600–2. doi:10.1097/PAS.0b013e31822832c7.

    Article  PubMed  Google Scholar 

  6. Bishop JA, Yonescu R, Batista DA, Westra WH, Ali SZ. Cytopathologic features of mammary analogue secretory carcinoma. Cancer Cytopathol. 2012. doi:10.1002/cncy.21245.

    Google Scholar 

  7. Griffith C, Seethala R, Chiosea SI. Mammary analogue secretory carcinoma: a new twist to the diagnostic dilemma of zymogen granule poor acinic cell carcinoma. Virchows Arch. 2011;459(1):117–8. doi:10.1007/s00428-011-1098-6.

    Article  PubMed  Google Scholar 

  8. Lei Y, Chiosea SI. Re-evaluating historic cohort of salivary acinic cell carcinoma with new diagnostic tools. Head Neck Pathol. 2012;6(2):166–70. doi:10.1007/s12105-011-0312-9.

    Article  PubMed  Google Scholar 

  9. Chiosea SI, Griffith C, Assaad A, Seethala RR. The profile of acinic cell carcinoma after recognition of mammary analog secretory carcinoma. Am J Surg Pathol. 2012;36(3):343–50. doi:10.1097/PAS.0b013e318242a5b0.

    Article  PubMed  Google Scholar 

  10. Ito S, Ishida E, Skalova A, Matsuura K, Kumamoto H, Sato I. Case report of Mammary Analog Secretory Carcinoma of the parotid gland. Pathol Int. 2012;62(2):149–52. doi:10.1111/j.1440-1827.2011.02759.x.

    Article  PubMed  CAS  Google Scholar 

  11. Levine P, Fried K, Krevitt LD, Wang B, Wenig BM. Aspiration biopsy of mammary analogue secretory carcinoma of accessory parotid gland: another diagnostic dilemma in matrix-containing tumors of the salivary glands. Diagn Cytopathol. 2012. doi:10.1002/dc.22886.

    PubMed  Google Scholar 

  12. Petersson F, Lian D, Chau YP, Yan B. Mammary analogue secretory carcinoma: the first submandibular case reported including findings on fine needle aspiration cytology. Head Neck Pathol. 2012;6(1):135–9. doi:10.1007/s12105-011-0283-x.

    Article  PubMed  Google Scholar 

  13. Pisharodi L. Mammary analog secretory carcinoma of salivary gland: cytologic diagnosis and differential diagnosis of an unreported entity. Diagn Cytopathol. 2012. doi:10.1002/dc.21766.

    PubMed  Google Scholar 

  14. Rastatter JC, Jatana KR, Jennings LJ, Melin-Aldana H. Mammary analogue secretory carcinoma of the parotid gland in a pediatric patient. Otolaryngol Head Neck Surg. 2012;146(3):514–5. doi:10.1177/0194599811419044.

    Article  PubMed  Google Scholar 

  15. Sams RN, Gnepp DR. P63 Expression can be used in differential diagnosis of salivary gland acinic cell and mucoepidermoid carcinomas. Head Neck Pathol. 2012. doi:10.1007/s12105-012-0403-2.

    PubMed  Google Scholar 

Download references

Acknowledgments

We are grateful to Mrs. Robyn Roche for outstanding secretarial support and to the In Situ and Developmental Laboratory, Department of Pathology, University of Pittsburgh Medical Center for excellent technical support.

Conflict of interests

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lindsay Williams.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Williams, L., Chiosea, S.I. Mammary Analogue Secretory Carcinoma Mimicking Salivary Adenoma. Head and Neck Pathol 7, 316–319 (2013). https://doi.org/10.1007/s12105-013-0443-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12105-013-0443-2

Keywords

Navigation