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Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer

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Abstract

Objectives The current study examined the role of estrogen receptors (ER), progesterone receptors (PR) and p53 expression in adenoid cystic carcinoma (ACC) to determine if simple expression or possible overexpression of these products might influence the development and natural course of this cancer. Study Design ER and PR status and p53 overexpression were retrospectively evaluated utilizing immunohistochemical evaluation of 47 ACC specimens. Methods Formalin-fixed paraffin-embedded tissues from 47 ACC specimens and 47 samples of normal salivary gland tissue were evaluated histochemically for the presence of ER, PR and p53. Immunoreactivity was scored using a 0 to +3 scale in which staining was either (0) negative, (+1) spotty, (+2) weakly positive, or (+3) strongly positive. Results ER was expressed in 8 of 47 tumors while PR was expressed in 4 of 47 tumors. p53 aberrations were demonstrated in 26 of 47 tumors. Tumors showed varying degrees of immunopositivity ranging from 0 to +3. Conclusions These studies suggest that p53 aberrations may be involved in ACC tumor progression and that ER and PR may play a role in ACC development.

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Acknowledgements

This work was supported by a grant from the National Organization for Rare Disorders, Inc.

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Authors and Affiliations

  1. Department of Otolaryngology, Stanford University, School of Medicine, 801 Welch Road, Stanford, CA, 94305, USA

    Jose E. Barrera

  2. Department of Pathology, University of Colorado, School of Medicine, Denver, CO, USA

    Kenneth R. Shroyer, Sherif Said & Robert O. Greer

  3. Division of Oral and Maxillofacial Pathology, University of Colorado, School of Dentistry, Denver, CO, USA

    George Hoernig & Robert O. Greer

  4. Oral Pathology Associates, Los Angeles, CA, USA

    Raymond Melrose

  5. Section of Oral Pathology, New York Hospital of Queens, Flushing, NY, USA

    Paul D. Freedman

  6. Department of Pathology, Meharry Medical College, Nashville, TN, USA

    Tanya A. Wright

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  1. Jose E. Barrera
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  2. Kenneth R. Shroyer
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  3. Sherif Said
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  4. George Hoernig
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  5. Raymond Melrose
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  6. Paul D. Freedman
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  7. Tanya A. Wright
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  8. Robert O. Greer
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Correspondence to Jose E. Barrera.

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Barrera, J.E., Shroyer, K.R., Said, S. et al. Estrogen and Progesterone Receptor and p53 Gene Expression in Adenoid Cystic Cancer. Head and Neck Pathol 2, 13–18 (2008). https://doi.org/10.1007/s12105-007-0032-3

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  • DOI: https://doi.org/10.1007/s12105-007-0032-3

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