Abstract
Objective
To assess the effectiveness of micronutrient powder (MNP) supplementation in reducing anemia levels in children aged 6 mo to 6 y in India.
Methods
Sixty sachets of MNP (Sprinkles Plus) were administered flexibly over a 4 mo period to 17,124 children at anganwadi centers or at home through Integrated Child Development Services (ICDS). Compliance was monitored using compliance cards and an assessment of mother’s recall at post-intervention survey. Hemoglobin was measured in separate random samples of 1,786 children before and 1,782 children after MNP supplementation.
Results
Mean compliance rate was estimated at 56.4 % (based on mother’s recall) and 91.7 % (based on compliance cards) for children who received MNP at home. Mean compliance was 96.9 % (based on compliance cards) for children who received MNP at anganwadis. A significant reduction in anemia (50 % to 33 % in boys; p-value < .000; 47.4 % to 34.2 % in girls) was seen following MNP supplementation.
Conclusions
Integration of a flexibly administered MNP supplementation into the ICDS is effective in reducing and treating anemia in children 6 mo to 6 y age.
Similar content being viewed by others
References
Kotecha PV. Micronutrient malnutrition in India: Let us say “no” to it now. Indian J Community Med. 2008;33:9–10.
International Institute for Population Sciences. National Family Health Survey (NFHS-3), 2005–06, India: Key findings. Mumbai: IIPS; 2007. pp. 14–6.
Copenhagen Consensus 2008. Results: Copenhagen Business School, Denmark; 2008. Available from: http://www.copenhagenconsensus.com/Admin/Public/DWSDownload.aspx?File=%2fFiles%2fFiler%2fCC08%2fPresse++result%2fCC08_results_FINAL.pdf.
Semba RD. The historical evolution of thought regarding multiple micronutrient nutrition. J Nutr. 2012;142:143S–56.
Lynch SR. The impact of iron fortification on nutritional anaemia. Best Pract Res Clin Haematol. 2005;18:333–46.
Viteri FE, Alvarez E, Batres R, Torún B, Pineda O, Mejía LA, et al. Fortification of sugar with iron sodium ethylenediaminotetraacetate (FeNaEDTA) improves iron status in semirural Guatemalan populations. Am J Clin Nutr. 1995;61:1153–63.
Andang’o PE, Osendarp SJ, Ayah R, West CE, Mwaniki DL, De Wolf CA, et al. Efficacy of iron-fortified whole maize flour on iron status of schoolchildren in Kenya: A randomised controlled trial. Lancet. 2007;369:1799–806.
Ndemwa P, Klotz CL, Mwaniki D, Sun K, Muniu E, Andango P, et al. Relationship of the availability of micronutrient powder with iron status and hemoglobin among women and children in the Kakuma Refugee Camp, Kenya. Food Nutr Bull. 2011;32:286–91.
Bilukha O, Howard C, Wilkinson C, Bamrah S, Husain F. Effects of multimicronutrient home fortification on anemia and growth in Bhutanese refugee children. Food Nutr Bull. 2011;32:264–76.
de Pee S, Spiegel P, Kraemer K, Wilkinson C, Bilukha O, Seal A, et al. Assessing the impact of micronutrient intervention programs implemented under special circumstances—meeting report. Food Nutr Bull. 2011;32:256–63.
De-Regil LM, Suchdev PS, Vist GE, Walleser S, Pena-Rosas JP. Home fortification of foods with multiple micronutrient powders for health and nutrition in children under two years of age. Cochrane Database Syst Rev. 2011;9:CD008959.
Christofides A, Schauer C, Zlotkin SH. Iron deficiency anemia among children: Addressing a global public health problem within a Canadian context. Paediatr Child Health. 2005;10:597–601.
Christofides A, Asante KP, Schauer C, Sharieff W, Owusu-Agyei S, Zlotkin S. Multi-micronutrient Sprinkles including a low dose of iron provided as microencapsulated ferrous fumarate improves haematologic indices in anaemic children: A randomized clinical trial. Maternal Child Nutr. 2006;2:169–80.
Hyder SMZ, Haseen F, Rahman M, Tondeur MC, Zlotkin SH. Effect of daily versus once-weekly home fortification with micronutrient Sprinkles on hemoglobin and iron status among young children in rural Bangladesh. Food Nutr Bull. 2007;28:156–64.
Hirve S, Bhave S, Bavdekar A, Naik S, Pandit A, Schauer C, et al. Low dose ‘Sprinkles’—an innovative approach to treat iron deficiency anemia in infants and young children. Indian Pediatr. 2007;44:91–100.
Zlotkin S, Arthur P, Schauer C, Antwi KY, Yeung G, Piekarz A. Home-fortification with iron and zinc Sprinkles or iron Sprinkles alone successfully treats anemia in infants and young children. J Nutr. 2003;133:1075–80.
Zlotkin S. More proof that home fortification is of value in children with iron deficiency anemia. Arch Pediatr Adolesc Med. 2012;166:869–70.
Adu-Afarwuah S, Lartey A, Brown KH, Zlotkin S, Briend A, Dewey KG. Home fortification of complementary foods with micronutrient supplements is well accepted and has positive effects on infant iron status in Ghana. Am J Clin Nutr. 2008;87:929–38.
Lundeen E, Schueth T, Toktobaev N, Zlotkin S, Hyder SM, Houser R. Daily use of Sprinkles micronutrient powder for 2 months reduces anemia among children 6 to 36 months of age in the Kyrgyz Republic: A cluster-randomized trial. Food Nutr Bull. 2010;31:446–60.
Sharieff W, Yin SA, Wu M, Yang Q, Schauer C, Tomlinson G, et al. Short-term daily or weekly administration of micronutrient Sprinkles has high compliance and does not cause iron overload in Chinese schoolchildren: A cluster-randomised trial. Public Health Nutr. 2006;9:336–44.
Giovannini M, Sala D, Usuelli M, Livio L, Francescato G, Braga M, et al. Double-blind, placebo-controlled trial comparing effects of supplementation with two different combinations of micronutrients delivered as Sprinkles on growth, anemia, and iron deficiency in cambodian infants. J Pediatr Gastroenterol Nutr. 2006;42:306–12.
Kounnavong S, Sunahara T, Mascie-Taylor CG, Hashizume M, Okumura J, Moji K, et al. Effect of daily versus weekly home fortification with multiple micronutrient powder on haemoglobin concentration of young children in a rural area, Lao People’s Democratic Republic: A randomised trial. Nutr J. 2011;10:129.
Schauer C, Zlotkin S. Home fortification with micronutrient Sprinkles—A new approach for the prevention and treatment of nutritional anemias. Paediatr Child Health. 2003;8:87–90.
Dewey KG. Increasing iron intake of children through complementary foods. Food Nutr Bull. 2007;28:S595–609.
Menon P, Ruel MT, Loechl CU, Arimond M, Habicht JP, Pelto G, et al. Micronutrient Sprinkles reduce anemia among 9- to 24-mo-old children when delivered through an integrated health and nutrition program in rural Haiti. J Nutr. 2007;137:1023–30.
de Pee S, Moench-Pfanner R, Martini E, Zlotkin S, Darnton-Hill I, Bloem MW. Home fortification in emergency response and transition programming: Experiences in Aceh and Nias, Indonesia. Food Nutr Bull. 2007;28:189–97.
Allen LH, Rosado JL, Casterline JE, López P, Muñoz E, Garcia OP, et al. Lack of hemoglobin response to iron supplementation in anemic mexican preschoolers with multiple micronutrient deficiencies. Am J Clin Nutr. 2000;71:1485–94.
Zlotkin SH, Christofides AL, Hyder SM, Schauer CS, Tondeur MC, Sharieff W. Controlling iron deficiency anemia through the use of home-fortified complementary foods. Indian J Pediatr. 2004;71:1015–9.
Sharieff W, Bhutta Z, Schauer C, Tomlinson G, Zlotkin S. Micronutrients (including zinc) reduce diarrhoea in children: The Pakistan Sprinkles Diarrhoea Study. Arch Dis Child. 2006;91:573–9.
Sprinkles Global Health Initiative. About Sprinkles; 2012(23/07/2012). Available from: http://www.sghi.org/about_sprinkles/index.html.
Ip H, Hyder SM, Haseen F, Rahman M, Zlotkin SH. Improved adherence and anaemia cure rates with flexible administration of micronutrient Sprinkles: A new public health approach to anaemia control. Eur J Clin Nutr. 2009;63:165–72.
Acknowledgments
The authors are grateful to the ICDS officers, supervisors and Anganwadi workers for their role in implementation of the intervention. Also, they are grateful to all the mothers who consented for their children to participate in this intervention.
Contributions
SH, EM, SKJ, AB, NH, DLY, AP contributed to the concept and design of the study. SH, EM, SKJ, DA, MM, SJ, contributed to the data acquisition, data analysis and data interpretation. SH, SJ, contributed to drafting the manuscript. EM, SKJ, DA, AB, MS, MM, NH, DLY, AP contributed to critically revising the manuscript for important intellectual content. All authors approved the final manuscript.
Conflict of Interest
None.
Role of Funding Source
This work was supported by HJ Heinz Foundation and Helen Keller International.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hirve, S., Martini, E., Juvekar, S.K. et al. Delivering Sprinkles Plus through the Integrated Child Development Services (ICDS) to Reduce Anemia in Pre-school Children in India. Indian J Pediatr 80, 990–995 (2013). https://doi.org/10.1007/s12098-013-1063-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12098-013-1063-2