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Analysis of related factors of cervical intraepithelial neoplasia complicated with vaginal intraepithelial neoplasia

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Abstract

Purpose

To explore the underlying risk factors and to prevent misdiagnosis of cervical intraepithelial neoplasia (CIN) coexisted with vaginal intraepithelial neoplasia (VaIN).

Methods

Clinical data of patients pathologically diagnosed with CIN were collected from January 2017 to December 2018. A total of 446 cases were analyzed, including 406 cases of single lesions (‘CIN single’ group) and 40 cases complicated with VAIN (‘VAIN concurrent’ group).

Results

The median age of the VAIN concurrent group was 53 years (46.25–59 years), and the median age of the CIN single group was 44 years (36–50 years). Regarding menopausal status, there were 28 cases (70.0%) in the VAIN concurrent group and 89 cases (21.9%) in the CIN single group (P < 0.005). The median load of high-risk human papillomavirus (Hr-HPV) in the VAIN concurrent and CIN single group was 923.4 relative light units/cutoff (RLU/CO) (145–2172.2 RLU/CO) and 229.155 RLU/CO (18.615–638.1275 RLU/CO), respectively (P = 0.037). The results revealed that the menopausal status was an independent risk factor for VAIN occurrence in CIN patients. The risk of VAIN in menopausal patients was higher than that in non-menopausal CIN patients (OR = 8.311, 95% CI 4.062–17.005). Age and HPV load were also related to the concurrence of VAIN and CIN.

Conclusion

Examinations regarding vaginal screening are of great importance in the diagnosis of perimenopausal and postmenopausal CIN patients, especially patients with Hr-HPV load. Colposcopy and tissue biopsy should also be performed, when necessary, to avoid misdiagnosis and the appearance of vaginal lesions.

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Author notes

  1. Y.Y. Zhang and R. Xia contributed equally to this work.

Authors and Affiliations

  1. Department of Gynecology, Cancer Hospital of China Medical University, 44 River Road, Dadong, Shenyang, Liaoning, 110042, People’s Republic of China

    Y.Y. Zhang, D. Chen & X. Zhang

  2. Department of Pain and Rehabilitation (Psychology Clinic), Cancer Hospital of China Medical University, Shenyang, Liaoning, 110042, People’s Republic of China

    R. Xia

Authors
  1. Y.Y. Zhang
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  2. R. Xia
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  3. D. Chen
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  4. X. Zhang
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Contributions

YZ designed the study and drafted the manuscript. RX and DC were responsible for the collection and analysis of the experimental data. YZ and XZ revised the manuscript critically for important intellectual content. All authors read and approved the final manuscript.

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Correspondence to X. Zhang.

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The authors declare that they have no conflict of interest.

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The study was approved by Ethical Committee of Cancer Hospital of China Medical University and conducted in accordance with the ethical standards.

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Zhang, Y., Xia, R., Chen, D. et al. Analysis of related factors of cervical intraepithelial neoplasia complicated with vaginal intraepithelial neoplasia. Clin Transl Oncol 24, 902–908 (2022). https://doi.org/10.1007/s12094-021-02739-x

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  • DOI: https://doi.org/10.1007/s12094-021-02739-x

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