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Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review

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  • Current Technology in Cancer Research and Treatment
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Abstract

Mouse cancer models have consistently been used to qualify new anticancer drugs in the development of human clinical trials. Rodent tumour models currently being used and which include transgenic tumour models, and those generated by planting human tumour cell lines subcutaneously in immunodeficient mice, do not sufficiently represent clinical cancer characteristics, especially with regard to metastasis and drug sensitivity. The increasingly used patient-derived human tumour tissue (PDTT) xenografts models implanted subcutaneously or in subrenal capsule in immunodeficient mice, such as athymic nude mice or severe combined immune deficient (SCID) mice, may provide a more accurate reflection of human tumour biological characteristics than tumour cell lines. The ability to passage patients’ fresh tumour tissues into large numbers of immunodeficient mice provides possibilities for better preclinical testing of new therapies for the treatment and better outcome for cancer. In this review, we outline the methods of establishing xenograft models, discuss the biological stability of PDTT xenograft models and demonstrate their roles in developing new anticancer drugs and testing therapeutic regimens in cancer patients.

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Authors and Affiliations

  1. Department of Surgical Oncology First Affiliated Hospital, College of Medicine Zhejiang University, 79 Qingchun Road, Hangzhou, Zhejiang, 310003, China

    Ketao Jin, Lisong Teng, Yanping Shen, Kuifeng He & Guangliang Li

  2. Department of Surgery, Zhuji Hospital, Zhuji, Zhejiang, China

    Ketao Jin

  3. Sir Run Run Shaw Institute of Clinical Medicine, Zhejiang University Key Laboratory of Biotherapy of Zhejiang Province, Hangzhou, Zhejiang, China

    Zhenzhen Xu

Authors
  1. Ketao Jin
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  2. Lisong Teng
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  3. Yanping Shen
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  4. Kuifeng He
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  5. Zhenzhen Xu
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  6. Guangliang Li
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Correspondence to Lisong Teng.

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Jin, K., Teng, L., Shen, Y. et al. Patient-derived human tumour tissue xenografts in immunodeficient mice: a systematic review. Clin Transl Oncol 12, 473–480 (2010). https://doi.org/10.1007/s12094-010-0540-6

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  • DOI: https://doi.org/10.1007/s12094-010-0540-6

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