Skip to main content
Log in

ROMO1 links oxidative stress to mitochondrial integrity

  • Commentary
  • Published:
Journal of Cell Communication and Signaling Aims and scope

Abstract

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  • Alfadda AA, Sallam RM (2012) Reactive oxygen species in health and disease. J Biomed Biotechnol 2012:936486

    Article  PubMed Central  PubMed  Google Scholar 

  • Bandyopadhyay S, Lane T, Venugopal R, Parthasarathy PT, Cho Y, Galam L, Lockey R, Kolliputi N (2013) MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2. Biochem Biophys Res Commun 439(3):407–412

    Article  CAS  PubMed  Google Scholar 

  • Bansal S, Biswas G, Avadhani NG (2014) Mitochondria-targeted heme oxygenase-1 induces oxidative stress and mitochondrial dysfunction in macrophages, kidney fibroblasts and in chronic alcohol hepatotoxicity. Redox Biol 2:273–283

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Brieger K, Schiavone S, Miller FJ Jr, Krause KH (2012) Reactive oxygen species: from health to disease. Swiss Med Wkly 142:w13659

    CAS  PubMed  Google Scholar 

  • Chung YM, Kim JS, Yoo YD (2006) A novel protein, Romo1, induces ROS production in the mitochondria. Biochem Biophys Res Commun 347(3):649–655

    Article  CAS  PubMed  Google Scholar 

  • Chung YM, Lee SB, Kim HJ, Park SH, Kim JJ, Chung JS, Yoo YD (2008) Replicative senescence induced by Romo1-derived reactive oxygen species. J Biol Chem 283(48):33763–33771

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Cogliati S, Frezza C, Soriano ME, Varanita T, Quintana-Cabrera R, Corrado M, Cipolat S, Costa V, Casarin A, Gomes LC, Perales-Clemente E, Salviati L, Fernandez-Silva P, Enriquez JA, Scorrano L (2013) Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency. Cell 155(1):160–171

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Grivennikova VG, Vinogradov AD (2013) Mitochondrial production of reactive oxygen species. Biochemistry (Mosc) 78(13):1490–1511

    Article  CAS  Google Scholar 

  • Lee SH, Lee JS, Lee EJ, Min KH, Hur GY, Lee SH, Lee SY, Kim JH, Lee SY, Shin C, Shim JJ, Kang KH, In KH (2014) Serum reactive oxygen species modulator 1 (Romo1) as a potential diagnostic biomarker for non-small cell lung cancer. Lung Cancer 85(2):175–181

    Article  PubMed  Google Scholar 

  • Na AR, Chung YM, Lee SB, Park SH, Lee MS, Yoo YD (2008) A critical role for Romo1-derived ROS in cell proliferation. Biochem Biophys Res Commun 369(2):672–678

    Article  CAS  PubMed  Google Scholar 

  • Namsolleck P, Unger T (2014) Aldosterone synthase inhibitors in cardiovascular and renal diseases. Nephrol Dial Transplant 29(Suppl 1):i62–i68

    Article  CAS  PubMed  Google Scholar 

  • Norton M, Ng AC, Baird S, Dumoulin A, Shutt T, Mah N, Andrade-Navarro MA, McBride HM, Screaton RA (2014) ROMO1 is an essential redox-dependent regulator of mitochondrial dynamics. Sci Signal 7(310):ra10

    Article  PubMed  Google Scholar 

  • Ratnaparkhi A (2013) Signaling by folded gastrulation is modulated by mitochondrial fusion and fission. J Cell Sci 126(Pt 23):5369–5376

    Article  CAS  PubMed  Google Scholar 

  • Scorrano L (2013) Keeping mitochondria in shape: a matter of life and death. Eur J Clin Investig 43:886–893

    Article  CAS  Google Scholar 

  • Semenzato M, Scorrano L (2014) O ROM(e)O1, ROM(e)O1, wherefore art thou ROM(e)O1? Sci Signal 7(310):pe2

    Article  PubMed  Google Scholar 

  • Shin JA, Chung JS, Cho SH, Kim HJ, Yoo YD (2013) Romo1 expression contributes to oxidative stress-induced death of lung epithelial cells. Biochem Biophys Res Commun 439(2):315–320

    Article  CAS  PubMed  Google Scholar 

  • Turrens JF (2003) Mitochondrial formation of reactive oxygen species. J Physiol 552(Pt 2):335–344

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Yu MO, Song NH, Park KJ, Park DH, Kim SH, Chae YS et al. (2014). Romo1 is associated with ROS production and cellular growth in human gloms. J Neurooncol (in press)

Download references

Acknowledgments

NK was funded by the American Heart Association National Scientist Development Grant 09SDG2260957 and National Institutes of Health R01 HL105932 and the Joy McCann Culverhouse Endowment to the Division of Allergy and Immunology.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Narasaiah Kolliputi.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Swarnabala, S., Gattu, M., Perry, B. et al. ROMO1 links oxidative stress to mitochondrial integrity. J. Cell Commun. Signal. 9, 73–75 (2015). https://doi.org/10.1007/s12079-014-0249-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12079-014-0249-3

Keywords

Navigation