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Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines

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Abstract

Idiosyncratic drug-induced liver injury mimics acute and chronic liver disease. It is under recognized and underrecognised because of the lack of pathognomonic diagnostic serological markers. Its consequences may vary from being asymptomatic to self-limiting illness to severe liver injury leading to acute liver failure. Its incidence is likely to be more common in Asia than other parts of the world, mainly because of hepatotoxicity resulting from the treatment of tuberculosis disease and the ubiquitous use of traditional and complimentary medicines in Asian countries. This APASL consensus guidelines on DILI is a concise account of the various aspects including current evidence-based information on DILI with special emphasis on DILI due to antituberculosis agents and traditional and complementary medicine use in Asia.

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, St John’s Medical College Hospital, Bangalore, India

    Harshad Devarbhavi

  2. NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and University of Nottingham, Nottingham, UK

    Guruprasad Aithal

  3. Department of Medicine, Chulalongkorn University, Bangkok, Thailand

    Sombat Treeprasertsuk

  4. Faculty of Medical Technology, Emeritus Professor, School of Medicine, Tokyo, Japan

    Hajime Takikawa

  5. Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, and Clinical Research Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Yimin Mao

  6. Department of Hepatology, Institute of Liver and Biliary Sciences, New Delhi, India

    Saggere M. Shasthry & Shiv K. Sarin

  7. Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan

    Saeed Hamid & Wasim Jafri

  8. Department of Medicine, Hospital Selayang, Bata Caves, Selangor, Malaysia

    Soek Siam Tan

  9. The Liver Institute, Center of Excellence in GI Sciences, Rajagiri Hospital, Aluva, Kerala, India

    Cyriac Abby Philips

  10. Department of Gastroenterology and Hepatology, Westmead Hospital and Sydney West Local Health District, Sydney, Australia

    Jacob George

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Devarbhavi, H., Aithal, G., Treeprasertsuk, S. et al. Drug-induced liver injury: Asia Pacific Association of Study of Liver consensus guidelines. Hepatol Int 15, 258–282 (2021). https://doi.org/10.1007/s12072-021-10144-3

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