Skip to main content

Advertisement

SpringerLink
Log in

Could Cellular Proliferation Be a Predictive Index for the Relapse of Nasal Polyposis and Down-Regulated by Nasal Steroid Treatment?

  • Original Article
  • Published:
Indian Journal of Otolaryngology and Head & Neck Surgery Aims and scope Submit manuscript

Abstract

The aim of this article is to identify the cellular mitotic activity using Ki-67 monoclonal antibody for predicting relapses of nasal polyposis after surgery. A prospective study was conducted at Kartal Training and Research Hospital Otolaryngology Department between January 2006 and September 2008. Nasal polyps were obtained from all patients and pathological materials were analyzed for the Ki-67 staining using immunohistochemistry. Patients were followed after surgery for 12 months for relapse. There was no statistically significant difference between recurrent and nonrecurrent polyps. Polyp recurrence has a multifactorial origin. Ki-67 index alone does not provide sufficient information about polyp recurrence before the operation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Coste A, Rateau JG, Roudot-Thoraval F, Chapelin C, Gilain L, Poron F, Peynegre R, Bernaudin JF, Escudier E (1996) Increased epithelial cell proliferation in nasal polyps. Arch Otolaryngol Head Neck Surg 122(4):432–436

    Article  PubMed  CAS  Google Scholar 

  2. Huisman MA, De Heer E, Grote JJ (2003) Cholesteatoma epithelium is characterized by increased expression of Ki-67, p53 and p21, with minimal apoptosis. Acta Otolaryngol 123(3):377–382

    PubMed  Google Scholar 

  3. Koda M, Sulkowski S, Kanczuga-Koda L, Surmacz E, Sulkowska M (2004) Expression of ERalpha, ERbeta and Ki-67 in primary tumors and lymph node metastases in breast cancer. Oncol Rep 11(4):753–759

    PubMed  CAS  Google Scholar 

  4. Liu M, Lawson G, Delos M, Jamart J, Ide C, Coche E, Weynand B, Desuter G, Hamoir M, Remacle M, Marbaix E (2003) Predictive value of the fraction of cancer cells immunolabeled for proliferating cell nuclear antigen or Ki-67 in biopsies of head and neck carcinomas to identify lymph node metastasis: comparison with clinical and radiologic examinations. Head Neck 25(4):280–288

    Article  PubMed  Google Scholar 

  5. Bussi M, Carlevato MT, Majore L, Battaglio S, Napoli P, Cortesina G (1995) The problem of recurrence of rhino-sinusal polyposis: pilot trial with locally administered azelastine HCL in the prevention of relapses. Acta Otorhinolaryngol Ital 15(2):101–106

    PubMed  CAS  Google Scholar 

  6. Morinaka S, Nakamura H (2000) Inflammatory cells in nasal mucosa and nasal polyps. Auris Nasus Larynx 27(1):59–64

    Article  PubMed  CAS  Google Scholar 

  7. Petruson B, Hansson HA, Petruson K (1988) Insulin-like growth factor I is a possible pathogenic mechanism in nasal polyps. Acta Otolaryngol 106(12):156–160

    Article  PubMed  CAS  Google Scholar 

  8. Xu Y, Wu Z, Tao Z, Hua Q, Jin K (2003) Possible role of transforming growth factor alpha on the cholesteatoma growth regulation. Lin Chuang Er Bi Yan Hou Ke Za Zhi 17(1):32–34

    Google Scholar 

  9. Hsu MC, Shun CT, Liu CM (2002) Increased epithelial cell proliferation in nasal polyps. J Formos Med Assoc 101(3):227–229

    PubMed  Google Scholar 

  10. Coste A, Rateau JG, Bernaudin JF, Peynegre R, Escudier E (1996) Nasal polyposis pathogenesis: a flow cytometric and immunohistochemical study of epithelial cell proliferation. Acta Otolaryngol 116(5):755–761

    Article  PubMed  CAS  Google Scholar 

  11. Bruno E, Mohamed El, Alessandrini M, Russo S, Schiaroli S, De Lorenzo A, Di Girolamo A (2002) Long-term follow-up of cellular proliferation as a predictive index for the relapse of nasal polyposis. Am J Rhinol 16(5):237–241

    PubMed  Google Scholar 

  12. Welkoborsky HJ, Portmann K, Hoffmann F, Jacob R, Mann WJ, Amedee RG (2000) Proliferative activity and cytometric characteristics in polyps of the nasal cavity and paranasal sinuses. Am J Rhinol 14(2):87–91

    Article  PubMed  CAS  Google Scholar 

  13. Kösem M, Bulut G, Kaya Z (2010) Analysis of Ki-67 immunoreactivity in recurring and nonrecurring nasal polyps. J Otolaryngol Head Neck Surg 39(4):464–467

    PubMed  Google Scholar 

  14. Cortesina G, Cardarelli L, Riontino E, Majore L, Ragona R, Bussi M (1999) Multi-center study of recurrent nasal sinus polyposis: prognostic factors and possibility of prophylaxis. Acta Otorhinolaryngol Ital 19(6):315–324

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Otorhinolaryngology, Gebze Government Hospital, Istanbul, Turkey

    Ilter Tezer

  2. Department of Otorhinolaryngology, Faculty of Medicine, Rize University, Rize, Turkey

    Ozlem Celebi Erdivanli

  3. Dr.Lutfi Kirdar Kartal Training and Research Hospital 2 nd ENT Department, Istanbul, Turkey

    Arif Sanli & Sedat Aydin

  4. KBB AD., Rize Üniversitesi Tıp Fakültesi, İslampaşa Mah., Merkez/Rize , 53100, Turkey

    Ozlem Celebi Erdivanli

Authors
  1. Ilter Tezer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ozlem Celebi Erdivanli
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Arif Sanli
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Sedat Aydin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ozlem Celebi Erdivanli.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Tezer, I., Celebi Erdivanli, O., Sanli, A. et al. Could Cellular Proliferation Be a Predictive Index for the Relapse of Nasal Polyposis and Down-Regulated by Nasal Steroid Treatment?. Indian J Otolaryngol Head Neck Surg 65 (Suppl 2), 329–332 (2013). https://doi.org/10.1007/s12070-012-0485-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12070-012-0485-x

Keywords

Search

Navigation