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New Y chromosomes and early stages of sex chromosome differentiation: sex determination in Megaselia

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Abstract

The phorid fly Megaselia scalaris is a laboratory model for the turnover and early differentiation of sex chromosomes. Isolates from the field have an XY sex-determining mechanism with chromosome pair 2 acting as X and Y chromosomes. The sex chromosomes are homomorphic but display early signs of sex chromosome differentiation: a low level of molecular differences between X and Y. The male-determining function (M), maps to the distal part of the Y chromosome’s short arm. In laboratory cultures, new Y chromosomes with no signs of a molecular differentiation arise at a low rate, probably by transposition of M to these chromosomes. Downstream of the primary signal, the homologue of the Drosophila doublesex (dsx) is part of the sex-determining pathway while Sex-lethal (Sxl), though structurally conserved, is not.

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  1. Institut für Biologie, Zentrum für medizinische Struktur- und Zellbiologie, Universität Lübeck, Ratzeburger Allee 160, D-23538, Lübeck, Germany

    Walther Traut

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Correspondence to Walther Traut.

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Traut, W. New Y chromosomes and early stages of sex chromosome differentiation: sex determination in Megaselia . J Genet 89, 307–313 (2010). https://doi.org/10.1007/s12041-010-0042-x

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  • DOI: https://doi.org/10.1007/s12041-010-0042-x

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