Skip to main content

Advertisement

SpringerLink
Log in

CAV1 is a prognostic predictor for patients with idiopathic pulmonary fibrosis and lung cancer

  • Published:
Journal of Biosciences Aims and scope Submit manuscript

Abstract

The extremely high mortality of both lung cancer and Idiopathic pulmonary fibrosis (IPF) is a global threat. Early detection and diagnosis can reduce their mortality. Since fibrosis is a necessary process of cancer, identifying the common potential prognostic genes involved in these two diseases will significantly contribute to disease prevention and targeted therapy. Microarray datasets of IPF and lung cancer were extracted from the GEO database. GEO2R was exploited to retrieve the differentially expressed genes (DEGs). The intersecting DEGs were obtained by the Venn tool. DAVID tools were used to perform GO and KEGG pathway enrichment analysis of DEGs. Then, the Kaplan–Meier plotter was employed to determine the prognostic value and verify the expression, pathological stage, and phosphorylation level of the hub gene in the TCGA and GTEx database. Finally, the extent of immune cell infiltration in lung cancer was estimated by the TIMER2 tool. The Venn diagram revealed 1 upregulated gene and 15 downregulated genes from GSE32863, GSE43458, GSE118370, and GSE75037 of lung cancer, as well as GSE2052 and GSE53845 of IPF. CytoHubba identified the top three genes [TEK receptor tyrosine kinase (TEK), caveolin 1 (CAV1), and endomucin (EMCN)] as hub genes following the connectivity degree. Survival analysis claimed the association of only TEK and CAV1 expression to both overall survival (OS) and first progression (FP). Pathological stage analyses revealed the relationship of only CAV1 expression to the pathological stage and the significant correlation of only CAV1 phosphorylation expression level for lung cancer. Furthermore, a statistically positive correlation was observed between the immune infiltration of cancer-associated fibroblasts, endothelial, and neutrophils with the CAV1 expression in lung cancer, whereas the contradictory result was noted for the immune infiltration of T cell follicular helper. Early detection and diagnostic potential of lung cancer are ameliorated by the combined selection of key genes among IPF and lung cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
Figure 6

Similar content being viewed by others

References

  • Bade BC and Dela Cruz CS 2020 Lung Cancer 2020: Epidemiology, etiology, and prevention. Clin. Chest Med. 41 1–24

    Article  Google Scholar 

  • Ballester B, Milara J and Cortijo J 2019 Idiopathic pulmonary fibrosis and lung cancer: mechanisms and molecular targets. Int. J. Mol. Sci. 20 593

    Article  CAS  Google Scholar 

  • Barrett T, Wilhite SE, Ledoux P, et al. 2013 NCBI GEO: archive for functional genomics data sets – update. Nucleic Acids Res. 41 D991–D995

    Article  CAS  Google Scholar 

  • Díaz MI, Díaz P, Bennett JC, Urra H, Ortiz R, Orellana PC, Hetz C and Quest AFG 2020 Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response. Cell Death Dis. 11 648

    Article  Google Scholar 

  • Domingues P, González-Tablas M, Otero Á, et al. 2016 Tumor infiltrating immune cells in gliomas and meningiomas. Brain Behav. Immun. 53 1–15

    Article  CAS  Google Scholar 

  • Glass DS, Grossfeld D, Renna HA, et al. 2020 Idiopathic pulmonary fibrosis: Molecular mechanisms and potential treatment approaches. Respir. Investig. 58 320–335

    Article  Google Scholar 

  • Gu-Trantien C, Loi S, Garaud S, et al. 2013 CD4+ follicular helper T cell infiltration predicts breast cancer survival. J. Clin. Invest. 123 2873–2892

    Article  CAS  Google Scholar 

  • Gvaramia D, Blaauboer ME, Hanemaaijer R and Everts V 2013 Role of caveolin-1 in fibrotic diseases. Matrix Biol. 32 307–315

    Article  CAS  Google Scholar 

  • Hoy H, Lynch T and Beck M 2019 Surgical Treatment of lung cancer. Crit. Care Nurs. Clin. North Am. 31 303–313

    Article  Google Scholar 

  • Ino Y, Yamazaki-Itoh R, Shimada K, Iwasaki M, Kosuge T, Kanai Y and Hiraoka N 2013 Immune cell infiltration as an indicator of the immune microenvironment of pancreatic cancer. Br. J. Cancer 108 914–923

    Article  CAS  Google Scholar 

  • Jang HJ, Park MS, Kim YS, Chang J, Lee JH, Lee CT, Lee SH and Yoon HI 2021 The relationship between the severity of pulmonary fibrosis and the lung cancer stage. J. Cancer. 12 2807–2814

    Article  CAS  Google Scholar 

  • Karampitsakos T, Tzilas V, Tringidou R, et al. 2017 Lung cancer in patients with idiopathic pulmonary fibrosis. Pulm. Pharmacol. Ther. 45 1–10

    Article  CAS  Google Scholar 

  • Kim HC, Lee S and Song JW 2021 Impact of idiopathic pulmonary fibrosis on clinical outcomes of lung cancer patients. Sci. Rep. 11 8312

    Article  CAS  Google Scholar 

  • Kinoshita T and Goto T 2019 Molecular mechanisms of pulmonary fibrogenesis and its progression to lung cancer: A review. Int. J. Mol. Sci. 20 1461

    Article  CAS  Google Scholar 

  • Lin X, Barravecchia M, Matthew Kottmann R, Sime P and Dean DA 2019 Caveolin-1 gene therapy inhibits inflammasome activation to protect from bleomycin-induced pulmonary fibrosis. Sci. Rep. 9 19643

    Article  CAS  Google Scholar 

  • Martinez FJ, Collard HR, Pardo A, et al. 2017 Idiopathic pulmonary fibrosis. Nat. Rev. Dis. Primers 3 17074

    Article  Google Scholar 

  • Nwosu ZC, Ebert MP, Dooley S and Meyer C 2016 Caveolin-1 in the regulation of cell metabolism: a cancer perspective. Mol. Cancer. 15 71

    Article  Google Scholar 

  • Qi W, Li X and Kang J 2014 Advances in the study of serum tumor markers of lung cancer. J Cancer Res. Ther. 10 C95–C101

    Article  Google Scholar 

  • Quest AF, Lobos-González L, Nuñez S, et al. 2013 The caveolin-1 connection to cell death and survival. Curr. Mol. Med. 13 266–281

    Article  CAS  Google Scholar 

  • Sanhueza C, Bennett JC, Valenzuela-Valderrama M, et al. 2020 Caveolin-1-mediated tumor suppression is linked to reduced HIF1α S-nitrosylation and transcriptional activity in hypoxia. Cancers 12 2349

    Article  CAS  Google Scholar 

  • Takahashi H, Sakakura K, Kudo T, Toyoda M, Kaira K, Oyama T and Chikamatsu K 2017 Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages. Oncotarget 8 8633–8647

    Article  Google Scholar 

  • Tang H, Zhang L, She YL, Su H and Chen C 2019 Surgical treatment of lung cancer patients with idiopathic pulmonary fibrosis. Zhonghua Wai Ke Za Zhi. 57 956–960

    CAS  PubMed  Google Scholar 

  • Tzouvelekis A, Gomatou G, Bouros E, Trigidou R, Tzilas V and Bouros D 2019 Common pathogenic mechanisms between idiopathic pulmonary fibrosis and lung cancer. Chest 156 383–391

    Article  Google Scholar 

  • Wang Z, Yang Q, Tan Y, Tang Y, Ye J, Yuan B and Yu W 2021 Cancer-associated fibroblasts suppress cancer development: the other side of the coin. Front. Cell Dev. Biol. 9 613534

    Article  Google Scholar 

  • Zhou W, He L, Dai Y, Zhang Y, Wang J and Liu B 2018 MicroRNA-124 inhibits cell proliferation, invasion and migration by targeting CAV1 in bladder cancer. Exp. Ther. Med. 16 2811–2820

    PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgements

We appreciate the Gene Expression Omnibus database and the Cancer Genome Atlas for the open data.

Author information

Author notes

  1. Dongdong Yin, Jiayang Qiu, Suxia Hu and Longqiang Cheng contributed equally to this work.

Authors and Affiliations

  1. First Affiliated Hospital, Anhui University of Science and Technology, Huainan, 232001, China

    Dongdong Yin, Jiayang Qiu, Suxia Hu, Longqiang Cheng, Hui Li, Xingpu Cheng, Shun Wang & Jun Lu

Authors
  1. Dongdong Yin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jiayang Qiu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Suxia Hu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Longqiang Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hui Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xingpu Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Shun Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jun Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jun Lu.

Additional information

Corresponding editor: Sreenivas Chavali

Corresponding editor: Sreenivas Chavali

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yin, D., Qiu, J., Hu, S. et al. CAV1 is a prognostic predictor for patients with idiopathic pulmonary fibrosis and lung cancer. J Biosci 47, 13 (2022). https://doi.org/10.1007/s12038-021-00245-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s12038-021-00245-4

Keywords

Search

Navigation