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RBD and Neurodegenerative Diseases

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Abstract

Rapid eye movement (REM) sleep behavior disorder (RBD) is a sleep disorder characterized by enacting one’s dreams during the REM sleep, with most of the dreams being violent or aggressive, so that patients often come to see the doctor complaining hurting themselves or bed partners during sleep. Prevalence of RBD, based on population, is 0.38–2.01 %, but much higher in patients with neurodegenerative diseases, especially synucleinopathies. RBD may herald the emergence of synucleinopathies by decades, such that it may be used as an effective early marker of neurodegenerative diseases. Pharmaceutical treatment of RBD includes clonazepam, melatonin, pramipexole, and some newly reported medications. In this review, we summarized the clinical and PSG features of RBD, the pathophysiology and the therapy of it, focusing on the correlation between neurodegenerative diseases and RBD, in order to emphasize the significance of RBD as an early marker of neurodegenerative diseases.

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Acknowledgments

This work was supported by grants 31171211 and 81471305 from the National Natural Science Foundation of China (to TW), grant 81200983 from the National Natural Science Foundation of China (to NX), grant 81301082 from the National Natural Science Foundation of China (to JSH), grant 2012B09 from China Medical Foundation (to NX) and grant 0203201343 from Hubei Molecular Imaging Key Laboratory (to NX). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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    1. Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Road, Wuhan, 430022, Hubei, China

      Haiyang Jiang, Jinsha Huang, Yan Shen, Shiyi Guo, Luxi Wang, Chao Han, Ling Liu, Kai Ma, Yun Xia, Jie Li, Xiaoyun Xu, Nian Xiong & Tao Wang

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    1. Haiyang Jiang
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    Haiyang Jiang and Jinsha Huang contributed equally to this work.

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    Jiang, H., Huang, J., Shen, Y. et al. RBD and Neurodegenerative Diseases. Mol Neurobiol 54, 2997–3006 (2017). https://doi.org/10.1007/s12035-016-9831-4

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