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The Functional and Molecular Properties, Physiological Functions, and Pathophysiological Roles of GluN2A in the Central Nervous System

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Abstract

The NMDA receptor, which is heavily involved in several human brain diseases, is a heteromeric ligand-gated ion channel that interacts with multiple intracellular proteins through the C-termini of different subunits. GluN2A and GluN2B are the two primary types of GluN2 subunits in the forebrain. During the developmental period, there is a switch from GluN2B- to GluN2A-containing NMDA receptors in synapses. In the adult brain, GluN2A exists at synaptic sites more abundantly than GluN2B. GluN2A plays important roles not only in synaptic plasticity but also in mediating physiological functions, such as learning and memory. GluN2A has also been involved in many common human diseases, such as cerebral ischemia, seizure disorder, Alzheimer’s disease, and systemic lupus erythematosus. The following review investigates the functional and molecular properties, physiological functions, and pathophysiological roles of the GluN2A subunit.

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Acknowledgments

The authors acknowledge support from the Natural Science Foundation of China (NSFC 81200886, NSFC 81402886), the Natural Science Foundation of Hebei Province (H2014208004), the Science and Technology Project of Hebei Province (13397703D), the Key Basic Research Program of the Application Foundation Research Project of Hebei Province (14967719D, 15962704D), the State Key Laboratory Breeding Base—Hebei Key Laboratory of Molecular Chemistry for Drug, and Hebei Research Center of Pharmaceutical and Chemical Engineering.

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  1. Department of Pharmacy, Hebei University of Science and Technology, Yuhua East Road 70, Shijiazhuang, Hebei, 050018, China

    Yongjun Sun, You chen, Liying Zhan & Zibin Gao

  2. Hebei Research Center of Pharmaceutical and Chemical Engineering, Hebei University of Science and Technology, Shijiazhuang, 050018, China

    Yongjun Sun & Zibin Gao

  3. North China Pharmaceutical Group New Drug Research and Development Co., Ltd, Shijiazhuang, 050015, China

    Xiaokun Cheng

  4. Department of Pathophysiology, Hebei Medical University, Shijiazhuang, 050017, China

    Linan Zhang

  5. School of Nursing, Hebei Medical University, Shijiazhuang, 050017, China

    Jie Hu

  6. State Key Laboratory Breeding Base—Hebei Province Key Laboratory of Molecular Chemistry for Drug, Shijiazhuang, 050018, China

    Zibin Gao

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Sun, Y., Cheng, X., Zhang, L. et al. The Functional and Molecular Properties, Physiological Functions, and Pathophysiological Roles of GluN2A in the Central Nervous System. Mol Neurobiol 54, 1008–1021 (2017). https://doi.org/10.1007/s12035-016-9715-7

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