Abstract
Signal transducer and activator of transcription 3 (STAT3) is aberrantly activated in glioblastoma and has been identified as a relevant therapeutic target in this disease and many other human cancers. After two decades of intensive research, there is not yet any approved STAT3-based glioma therapy. In addition to the canonical activation by tyrosine 705 phosphorylation, concordant reports described a potential therapeutic relevance of other post-translational modifications including mainly serine 727 phosphorylation. Such reports reinforce the need to refine the strategy of targeting STAT3 in each concerned disease. This review focuses on the role of serine 727 and tyrosine 705 phosphorylation of STAT3 in glioma. It explores their contribution to glial cell transformation and to the mechanisms that make glioma escape to both immune control and standard treatment.
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The CREaT/ EA7283-Auvergne University research team was supported by the Ligue Nationale Contre le Cancer (Comité du Puy-De-Dôme) of the Institut National du Cancer and by the Auvergne Region. ZG.O. was the recipient of a fellowship from the Ministère des Enseignements Secondaire et Supérieur, Burkina Faso.
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This work was supported by the Ligue Nationale Contre le Cancer (Comité du Puy-De-Dôme) by the Institut National du Cancer and by the Region Auvergne. ZG.O. was the recipient of a fellowship from the Ministère des Enseignements Secondaire et Supérieur, Burkina Faso.
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Ouédraogo, Z.G., Biau, J., Kemeny, JL. et al. Role of STAT3 in Genesis and Progression of Human Malignant Gliomas. Mol Neurobiol 54, 5780–5797 (2017). https://doi.org/10.1007/s12035-016-0103-0
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DOI: https://doi.org/10.1007/s12035-016-0103-0