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The Role of Collagens in Peripheral Nerve Myelination and Function

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Abstract

In the peripheral nervous system, myelin is formed by Schwann cells, which are surrounded by a basal lamina. Extracellular matrix (ECM) molecules in the basal lamina play an important role in regulating Schwann cell functions, including adhesion, survival, spreading, and myelination, as well as in supporting neurite outgrowth. Collagens are a major component of ECM molecules, which include 28 types that differ in structure and function. A growing body of evidence suggests that collagens are key components of peripheral nerves, where they not only provide a structural support but also affect cell behavior by triggering intracellular signals. In this review, we will summarize the main properties of collagen family, discuss the role of extensively studied collagen types (collagens IV, V, VI, and XV) in Schwann cell function and myelination, and provide a detailed overview of the recent advances with respect to these collagens in peripheral nerve function.

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Acknowledgments

We apologize to the authors whose papers could not be cited because of the limitation of space. This work was supported by the Italian Ministry of Education, University and Research (FIRB Strategic Project RBAP11Z3YA_003), the Cariparo Foundation, and the University of Padova.

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The authors declare no conflict of interest.

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  1. Department of Molecular Medicine, University of Padova, Via Ugo Bassi 58/B, 35131, Padova, Italy

    Peiwen Chen, Matilde Cescon & Paolo Bonaldo

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  1. Peiwen Chen
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  2. Matilde Cescon
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Chen, P., Cescon, M. & Bonaldo, P. The Role of Collagens in Peripheral Nerve Myelination and Function. Mol Neurobiol 52, 216–225 (2015). https://doi.org/10.1007/s12035-014-8862-y

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