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Electropsun Polycaprolactone Fibres in Bone Tissue Engineering: A Review

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Abstract

Regeneration of bone tissue requires novel load bearing, biocompatible materials that support adhesion, spreading, proliferation, differentiation, mineralization, ECM production and maturation of bone-forming cells. Polycaprolactone (PCL) has many advantages as a biomaterial for scaffold production including tuneable biodegradation, relatively high mechanical toughness at physiological temperature. Electrospinning produces nanofibrous porous matrices that mimic many properties of natural tissue extracellular matrix with regard to surface area, porosity and fibre alignment. The biocompatibility and hydrophilicity of PCL nanofibres can be improved by combining PCL with other biomaterials to form composite scaffolds for bone regeneration. This work reviews the most recent research on synthesis, characterization and cellular response to nanofibrous PCL scaffolds and the composites of PCL with other natural and synthetic materials for bone tissue engineering.

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  1. Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India

    Nadeem Siddiqui, Braja Kishori, Saranya Rao, Mohammad Anjum & Venkata Hemanth

  2. Department of Genetic Engineering, SRM Institute of Science and Technology, Chennai, Tamil Nadu, India

    Swati Das

  3. Biomaterials and Tissue Engineering Laboratory, Department of Chemical Engineering, University of South Carolina, Columbia, SC, 29208, USA

    Esmaiel Jabbari

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Siddiqui, N., Kishori, B., Rao, S. et al. Electropsun Polycaprolactone Fibres in Bone Tissue Engineering: A Review. Mol Biotechnol 63, 363–388 (2021). https://doi.org/10.1007/s12033-021-00311-0

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