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Influence of Small RNAs on Biofilm Formation Process in Bacteria

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Abstract

Small non-coding RNAs (sRNAs) play a significant role in regulation of bacterial physiological behaviors. After sensing any environmental cue such as fluctuation of nutrient concentration, temperature, pH, and osmolarity, these sRNAs interfere to transmit these signals to target regulators and genes. sRNAs have key role in biofilm formation process by base pairing with target mRNAs or interaction with modulating proteins to both positive and negative regulation mechanisms. There are various regulatory systems to characterize the initiation and formation of special bacterial biofilms that are mostly described as two component systems based on sRNAs functions. In this study, regulatory pathways that are important for biofilm formation and genetic responses to environmental stimuli in mature biofilms were evaluated. Some of the regulatory systems that produce common types of biofilms such as curli, PGA, cellulose and polysaccharides such as alginate, colonic acid, Psl and their involved sRNAs functions were also discussed.

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Authors and Affiliations

  1. Department of Chemical Engineering, Sahand University of Technology, PO Box 51335-1996, Tabriz, Iran

    Mohammad Ali Ghaz-Jahanian, Fatemeh Khodaparastan & Hoda Jafarizadeh-Malmiri

  2. School of Chemical and Biomolecular Engineering, The University of Sydney, Sydney, Australia

    Aydin Berenjian

Authors
  1. Mohammad Ali Ghaz-Jahanian
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  2. Fatemeh Khodaparastan
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  3. Aydin Berenjian
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  4. Hoda Jafarizadeh-Malmiri
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Correspondence to Hoda Jafarizadeh-Malmiri.

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Ghaz-Jahanian, M.A., Khodaparastan, F., Berenjian, A. et al. Influence of Small RNAs on Biofilm Formation Process in Bacteria. Mol Biotechnol 55, 288–297 (2013). https://doi.org/10.1007/s12033-013-9700-6

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