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Treatment on advanced NSCLC: Platinum-based chemotherapy plus erlotinib or platinum-based chemotherapy alone? A systematic review and meta-analysis of randomised controlled trials

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Abstract

We performed a systematic review and meta-analysis to assess the potential of erlotinib plus platinum-based chemotherapy relative to platinum-based chemotherapy alone for advanced non-small-cell lung cancer (NSCLC). Search of PubMed, EMBASE, Web of Science, CBM, CNKI, China Wan Fang databases and the Cochrane library was performed for studies regarding erlotinib plus platinum-based chemotherapy for advanced NSCLC published between 1 January 2000 and 28 August 2014. We identified eight eligible studies including 3,363 patients with advanced NSCLC. For PFS measure, an HR of 0.73 (0.58–0.93) with statistical significance was estimated when erlotinib plus platinum-based chemotherapy compared with platinum-based chemotherapy alone; objective response rate of 32.86 versus 24.85 % was obtained for both groups, respectively. HR of 0.93 (0.86–1.00) with P of 0.170 was calculated for OS. We concluded that the erlotinib plus chemotherapy for advanced NSCLC could increase PFS and objective response rate, but not benefit OS.

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Acknowledgments

The authors thank the reviewers for their helpful comments on this article. This work was supported by NSFC (Natural Science Foundation of China) (81360351), Start-Up Fund for Doctor of Zunyi Medical University and the Department of Science and Technology of Guizhou Province (Grant No. Qian Ke He SY [2013] 3003).

Conflict of interest

The authors have declared no conflicts of interest.

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Corresponding author

Correspondence to Hu Ma.

Additional information

Jian-Guo Zhou, Xu Tian and Xue Wang have contributed equally to this work.

Appendix: PubMed search terms

Appendix: PubMed search terms

#1 Search (((((((((Carcinoma, Non Small Cell Lung[Title/Abstract]) OR Carcinomas, Non Small Cell Lung[Title/Abstract]) OR Lung Carcinoma, Non-Small-Cell[Title/Abstract]) OR Lung Carcinomas, Non-Small-Cell[Title/Abstract]) OR Non-Small-Cell Lung Carcinomas[Title/Abstract]) OR Non small Cell Lung Cancer[Title/Abstract]) OR Non-Small-Cell Lung Carcinoma[Title/Abstract]) OR Carcinoma, Non-Small Cell Lung[Title/Abstract]) OR Non-Small Cell Lung Cancer[Title/Abstract]) OR “Carcinoma, Non-Small-Cell Lung”[Mesh].

#2 Search ((((((((((((OSI-774[Title/Abstract]) OR CP-358774[Title/Abstract]) OR CP-358,774[Title/Abstract]) OR CP 358,774[Title/Abstract]) OR CP 358774[Title/Abstract]) OR Tarceva[Title/Abstract]) OR 11C-erlotinib[Title/Abstract]) OR erlotinib HCl[Title/Abstract]) OR erlotinib hydrochloride[Title/Abstract]) OR N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine[Title/Abstract]) OR erlotinib[Title/Abstract])) OR “erlotinib” [Supplementary Concept].

#3 Search (((“Controlled Clinical Trial” [Publication Type]) OR (“Randomized Controlled Trials as Topic”[Mesh] OR “Randomized Controlled Trial” [Publication Type] OR “Controlled Clinical Trials as Topic”[Mesh]))) OR ((((((Controlled Clinical Trial[Title/Abstract]) OR Controlled Clinical Trials, Randomized[Title/Abstract]) OR Clinical Trials, Randomized[Title/Abstract]) OR Trials, Randomized Clinical[Title/Abstract]) OR Controlled Clinical Trials[Title/Abstract]) OR random*[Title/Abstract]).

#4: #1 AND #2 AND #3.

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Zhou, JG., Tian, X., Wang, X. et al. Treatment on advanced NSCLC: Platinum-based chemotherapy plus erlotinib or platinum-based chemotherapy alone? A systematic review and meta-analysis of randomised controlled trials. Med Oncol 32, 23 (2015). https://doi.org/10.1007/s12032-014-0471-0

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