Abstract
For bladder cancer, a new diagnostic marker is needed to avoid painful cystoscopy. The aim of this study was to explore the efficacy of urinary miRNA-96 as molecular marker in bladder cancer diagnosis and its relation to bilharziasis. Urine cytology, serologic assessment of schistosomiasis and estimation of miRNA-96 by real-time PCR were carried out for 94 bladder cancer patients, 30 benign bladder lesions and 60 healthy individuals. Expression of miRNA-96 showed a significant difference among the three tested groups and also between benign and malignant bilharzial cases. Urinary miRNA-96 is a good noninvasive diagnostic biomarker for bladder cancer.
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Acknowledgments
This work was supported by Ain Shams University Research Projects 2013-14. The authors acknowledge Prof. Nahla Awad, at the early cancer detection unit, Faculty of Medicine, Ain Shams University, for her help in the cytological examinations of urine samples and Dr. Yosif Kotb at Urology department.
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Eissa, S., Habib, H., Ali, E. et al. Evaluation of urinary miRNA-96 as a potential biomarker for bladder cancer diagnosis. Med Oncol 32, 413 (2015). https://doi.org/10.1007/s12032-014-0413-x
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DOI: https://doi.org/10.1007/s12032-014-0413-x