Abstract
The clinical significance of SLC7A7 expression remains unclear. In this study, we aimed to explore whether SLC7A7 expression in tumor tissues could be used to assess subsequent prognosis in patients with glioblastoma (GBM). A total of 119 patients with pathologically confirmed GBM and 16 normal controls were recruited for this study. The expression of SLC7A7 in GBM and normal tissues was evaluated by immunohistochemistry in tissue microarrays and quantitative real-time PCR. Kaplan–Meier method and Cox’s proportional hazards model were used in survival analysis. Compared with normal tissues, GBM specimens had significantly increased expression of SLC7A7 at both mRNA and protein levels (both P < 0.05). Moreover, multivariate analysis confirmed that overexpression of SLC7A7 was a significant and independent indicator for predicting poor prognosis. Our results suggest, for the first time, that overexpression of SLC7A7 is correlated with worse outcomes in patients with GBM. SLC7A7 plays a critical role in GBM carcinogenesis and may be a potential prognosis predictor of GBM.
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Acknowledgments
We wish to thank our volunteers for donating their tumoral or normal brain tissues. We also wish to thank the collaborators for collection of these tissue samples and information. Last but not least, we thank the Cancer Genome Atlas Research Network for providing data and the members of TCGA’s External Scientific Committee and the Glioblastoma Disease Working Group (http://cancergenome.nih.gov/components/). This work was supported by the Shanghai Science and Technology Research Program (Grants 09JC1402200 and 10410709100) and the Natural Science Foundation of China (Grants 30800622 and 81001114).
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Songhua Fan, Delong Meng, Tao Xu contribute equally to this work.
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Fan, S., Meng, D., Xu, T. et al. Overexpression of SLC7A7 predicts poor progression-free and overall survival in patients with glioblastoma. Med Oncol 30, 384 (2013). https://doi.org/10.1007/s12032-012-0384-8
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DOI: https://doi.org/10.1007/s12032-012-0384-8