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Association of TGIFLX/Y mRNA expression with prostate cancer

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Abstract

Prostate cancer is the most common type of solid tumor and a leading cause of cancer-related death of men living in the developed world. In recent years, the molecular mechanisms involved in prostate cancer development and/or progression have been intensely studied and several genes have been identified. TGIFLX/Y (TGIFLX and TGIFLY) are members of the homeobox superfamily of genes whose function(s) is unknown. To investigate TGIFLX/Y mRNA expression in prostate cancer, we studied two different types of clinical samples, namely 60 prostate tumors and 15 cases of benign prostate hyperplasia (BPH), by RT-PCR. Our results revealed that most prostate tumors (73.5%) express at least one of these genes, although different patterns of TGIFLX/Y mRNA expression were observed. In some tumor samples the expression of both genes was detected, while in others no expression of either gene was observed. Notably, there was a significant correlation between expression of both TGIFLX and TGIFLY and a Gleason score of ≥6 (P = 0.038). By contrast, expression of TGIFLX/Y mRNA in BPH samples could not be detected. These results suggest an association of TGIFLX/Y expression with the progression of prostate cancer.

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Acknowledgments

We thank Ms. S. Moradkhani and Ms. M. Rezaie for their kind efforts in collecting the prostate samples and datasheets, Dr N. Pouladi for his advice on statistical analysis. This project was supported by a grant from the Tehran University of Medical Sciences.

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Authors and Affiliations

  1. Department of Medical Genetics, Medical Sciences/University of Tehran, Pour Sina Ave, Tehran, Iran

    Z. Ousati Ashtiani, M. H. Modarresi, R. Raoofian & M. Heidari

  2. Department of Urology, Imam Khomeini Hospital, Tehran, Iran

    M. Ayati

  3. Bistoon Ultrasound Clinic, Tehran, Iran

    B. Sabah Goulian

  4. School of Veterinary and Biomedical Sciences, Murdoch University, Perth, WA, 6150, Australia

    W. K. Greene

Authors
  1. Z. Ousati Ashtiani
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  2. M. Ayati
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  3. M. H. Modarresi
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  4. R. Raoofian
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  5. B. Sabah Goulian
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  6. W. K. Greene
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  7. M. Heidari
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Correspondence to M. Heidari.

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Ousati Ashtiani, Z., Ayati, M., Modarresi, M.H. et al. Association of TGIFLX/Y mRNA expression with prostate cancer. Med Oncol 26, 73–77 (2009). https://doi.org/10.1007/s12032-008-9086-7

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  • DOI: https://doi.org/10.1007/s12032-008-9086-7

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