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Prognostic Role of Chicken Ovalbumin Upstream Promoter Transcription Factor II in Isocitrate Dehydrogenase-Mutant Glioma with 1p19q Co-Deletion

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Abstract

Background

Chicken ovalbumin upstream promoter transcription factor II is known to play a crucial role in the tumor microenvironment. However, the role of NR2F2 in gliomas is unknown.

Methods

The genomic and clinical data of 530 cases of lower grade gliomas (LGGs) patients and 167 cases of glioblastoma (GBM) patients in The Cancer Genome Atlas (TCGA) were extracted for analysis. R2 and UCSC Xena browser were used for Kaplan–Meier survival in the GSE16011 dataset and TCGA dataset, respectively. GraphPad Prism 7 was used to compare the differences in NR2F2 expression between various groups and subtypes.

Results

LGG patients with low NR2F2 expression had a significantly favorable outcome compared with those with high NR2F2 expression (p < 0.05). By matching histological subtypes and gene expression profiles of LGG patients, grade II glioma group showed lowest levels of NR2F2 expression compared with grade III gliomas and GBM. Patients diagnosed with astrocytoma have highest expression of NR2F2 but lowest OS (p < 0.05). In LGGs, NR2F2 expression was significantly downregulated in patient group with IDH mutation and 1p19q co-deletion (p < 0.05).

Conclusion

Our study suggests that NR2F2 can be used as a prognostic marker in LGG patients with IDH mutation and 1p19 co-deletion.

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Acknowledgments

We thank Dong Jie, PhD and Jiang Kaimo for their language editing assistance.

We acknowledge the TCGA Research Network (http://cancergenome.nih.gov/) for providing patient data.

Funding

This work was supported by the National Natural Science Foundation of China (No. 81470048 and No.81641076).

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Authors and Affiliations

  1. School of Clinical Medicine and Department of Neurosurgery, Yuquan Hospital, School of Clinical Medicine, Tsinghua University, Beijing, China

    Yi Chai, Wei Liu & Yuqi Zhang

  2. School of General Practice and Continuing Education, Capital Medical University, Beijing, China

    Caixia Wang

  3. Department of Oncology, Shangrao People Hospital, Shangrao, Jiangxi, China

    Minchao Rao

  4. Department of Neurosurgery, Yuquan Hospital, Tsinghua University, No. 5 Shijingshan Road, Shijingshan District, Beijing, 100040, China

    Yuqi Zhang

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  1. Yi Chai
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Correspondence to Yuqi Zhang.

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Chai, Y., Liu, W., Wang, C. et al. Prognostic Role of Chicken Ovalbumin Upstream Promoter Transcription Factor II in Isocitrate Dehydrogenase-Mutant Glioma with 1p19q Co-Deletion. J Mol Neurosci 68, 234–242 (2019). https://doi.org/10.1007/s12031-019-01281-4

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  • DOI: https://doi.org/10.1007/s12031-019-01281-4

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