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MicroRNA-206 Inhibited the Progression of Glioblastoma Through BCL-2

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A Correction to this article was published on 22 October 2020

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Abstract

Gliomas are the most common type of brain tumor and have a poor prognosis. MicroRNAs (miRNAs) are a class of small, endogenous, and non-coding RNAs that play crucial roles in cell proliferation, survival, and invasion. Deregulated expression of miR-206 has been investigated in many cancers. However, the role of miR-206 in glioblastoma is still unclear. In the present study, we found that the expression of miR-206 was decreased in cancer tissues compared with normal tissues. However, the expression level of BCL-2 was higher in cancer tissues than that in normal tissues (all p < 0.001). Statistically, the expression level of BCL-2 was inversely correlated with the miR-206. In addition, the overall survival of glioblastoma patients with lower miR-206 expression was significantly shorter than those with high miR-206 expression (p < 0.001). Besides, the expression of miR-206 was also decreased in U87 and U251 cells. In vitro assays showed that ectopic miR-206 expression affected the proliferation, cell cycle, and invasion in U87 and U251 cells. Importantly, we identified BCL-2 as a direct target of miR-206 in U87 and U251 cells using luciferase assay. Overexpression of BCL-2 partially attenuated the miR-206-mediated cell proliferation. In vivo, overexpression of miR-206 suppressed the progression of glioblastoma cells using mice xenograft model. In conclusion, this study suggested that miR-206 could act as a tumor suppressor gene through inhibiting BCL-2 in the development of glioblastoma.

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Change history

  • 22 October 2020

    The original version of this article unfortunately contained a mistake in the AuthorGroup section.

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Acknowledgment

This work was supported by some other members in our lab.

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Authors and Affiliations

  1. Department of Neurosurgery, The First Affiliated Hospital, School of Medicine, Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China

    Wenjiong Hao, Xiaobin Bai & Maode Wang

  2. Department of Neurosurgery, Affiliated Hospital, Medical College of Yan’an University, Yan’an City, Shaanxi, 716000, People’s Republic of China

    Wenjiong Hao, Mangmang Bai, Jian Li & Jie Guo

  3. Department of Neurosurgery, The Affiliated Hospital of Shaanxi Traditional Chinese Medicine University, Xianyang, 712000, People’s Republic of China

    Wei Luo

  4. Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China

    Jinsong Wu

Authors
  1. Wenjiong Hao
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  2. Wei Luo
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  3. Mangmang Bai
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  4. Jian Li
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  5. Xiaobin Bai
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  6. Jie Guo
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  7. Jinsong Wu
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  8. Maode Wang
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Correspondence to Maode Wang.

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Hao, W., Luo, W., Bai, M. et al. MicroRNA-206 Inhibited the Progression of Glioblastoma Through BCL-2. J Mol Neurosci 60, 531–538 (2016). https://doi.org/10.1007/s12031-016-0824-6

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  • DOI: https://doi.org/10.1007/s12031-016-0824-6

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