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OPCML Gene as a Schizophrenia Susceptibility Locus in Thai Population

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Abstract

Opioid-binding protein/cell adhesion molecule (OPCML) gene has been recently identified as a susceptibility gene for schizophrenia in Europeans. This study aims to investigate the association between single nucleotide polymorphisms (SNPs) in the OPCML gene and risk of schizophrenia in a Thai population. DNA samples of 115 schizophrenia patients and 173 normal controls were genotyped using high-resolution melting analysis and analyzed by chi-square test of SPSS software. We observed a strong association between an intronic SNP of the OPCML gene (rs1784519) and the risk of schizophrenia in the Thai population [P = 0.00036; odds ratio for the minor A allele, 2.11(1.57–2.84)]. The previously discovered SNP associated with schizophrenia in Europeans, rs3016384, also showed significant association with schizophrenia in the Thai population [P = 0.01; odds ratio of the minor T allele, 0.59 (0.44–0.79)]. Therefore, the OPCML gene is considered to be a schizophrenia-susceptible gene in the Thai population.

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Acknowledgments

This study was supported by the Royal Golden Jubilee Ph.D. Program of the Thailand Research Fund (PHD/0213/2551), Srinakharinwirot University (218/2552), a Grant-in-Aid from the Japanese Ministry of Health, Labor and Welfare, and by a Grant-in-Aid for Young Scientists (A) 21687021. This study was also subsidized by JKA through its promotion founds from KEIRIN RACE. The authors thank Dr. Alfredo Villarroel for editing the manuscript.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Medicine, Srinakharinwirot University, Sukhumvit 23, Bangkok, 10110, Thailand

    Benjaporn Panichareon & Wasana Sukhumsirichart

  2. Division of Human Genetics, Center for Molecular Medicine, Jichi Medical University, Shimotsuke, Japan

    Kazuhiro Nakayama & Sadahiko Iwamoto

  3. Department of Psychiatry, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand

    Wanpen Thurakitwannakarn

Authors
  1. Benjaporn Panichareon
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  2. Kazuhiro Nakayama
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  3. Wanpen Thurakitwannakarn
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  4. Sadahiko Iwamoto
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  5. Wasana Sukhumsirichart
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Corresponding author

Correspondence to Wasana Sukhumsirichart.

Additional information

Benjaporn Panichareon and Kazuhiro Nakayama contributed equally to this work.

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Panichareon, B., Nakayama, K., Thurakitwannakarn, W. et al. OPCML Gene as a Schizophrenia Susceptibility Locus in Thai Population. J Mol Neurosci 46, 373–377 (2012). https://doi.org/10.1007/s12031-011-9595-2

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  • DOI: https://doi.org/10.1007/s12031-011-9595-2

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