Skip to main content

Advertisement

SpringerLink
Log in

Platelet Distribution Width as a Predictor of Metastasis in Gastric Cancer Patients

  • Original Research
  • Published:
Journal of Gastrointestinal Cancer Aims and scope Submit manuscript

Abstract

Introduction

There are few known predictors of gastric cancer (GC). In this study, we evaluated the relationship between peripheral blood parameters and disease in patients with GC. Our aim was to identify a predictor of the development of metastasis.

Materials and Methods

Pretreatment peripheral blood parameters, including neutrophil, lymphocyte, and platelet counts; median platelet values (MPVs); and platelet distribution width (PDW), of patients diagnosed with GC were assessed. The independent T test was used in comparisons between two groups with a normal distribution, the Mann–Whitney U test in comparisons between two groups without a normal distribution, the Kruskal–Wallis test to compare more than two groups, and the Dunn’s multiple comparison test to compare subgroups. A p value <0.05 was considered statistically significant.

Results

In GC patients, neutrophil and platelet counts, but not lymphocyte counts and MPVs, increased significantly with disease stage progression. Among patients who developed a metastasis during follow-up, the relationship between PDW and the risk of metastasis was statistically significant (p = 0.04). Both lymphocyte and platelet levels had a statistically significant relationship to survival (p = 0.04 and p = 0.02, respectively).

Conclusions

Our results showed that in patients with GC, PDW, one of the standard parameters measured in a complete blood count, is a predictor of metastasis. Therefore, the PDW may be an important consideration in the surgical and chemotherapeutic treatment planning of patients with GC. Treatment strategies should also take into account lymphocyte and platelet levels, both of which were shown to be significantly related to survival.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Teramukai S, Kitano T, Kishida Y, Kawahara M, Kubota K, Komuta K, et al. Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03. Eur J Cancer. 2009;45(11):1950–8.

    Article  PubMed  Google Scholar 

  2. Yamanaka T, Matsumoto S, Teramukai S, Ishiwata R, Nagai Y, Fukushima M. The baseline ratio of neutrophils to lymphocytes is associated with patient prognosis in advanced gastric cancer. Oncology. 2006;73(3–4):215–20.

    Google Scholar 

  3. Shimada H, Oohira G, Okazumi S-i, Matsubara H, Nabeya Y, Hayashi H, et al. Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma. J Am Coll Surg. 2004;198(5):737–41.

    Article  PubMed  Google Scholar 

  4. Okuturlar Y, Gunaldi M, Tiken EE, Oztosun B, Inan YO, Ercan T, et al. Utility of peripheral blood parameters in predicting breast cancer risk. Asian Pac J Cancer Prev: APJCP. 2015;16(6):2409.

    Article  PubMed  Google Scholar 

  5. Aliustaoglu M, Bilici A, Ustaalioglu BBO, Konya V, Gucun M, Seker M, et al. The effect of peripheral blood values on prognosis of patients with locally advanced gastric cancer before treatment. Med Oncol. 2010;27(4):1060–5.

    Article  PubMed  Google Scholar 

  6. Li Q-Q, Lu Z-H, Yang L, Lu M, Zhang X-T, Li J, et al. Neutrophil count and the inflammation-based Glasgow prognostic score predict survival in patients with advanced gastric cancer receiving first-line chemotherapy. Asian Pac J Cancer Prev. 2014;15(2):945–50.

    Article  PubMed  Google Scholar 

  7. Herszenyi L, Tulassay Z. Epidemiology of gastrointestinal and liver tumors. Eur Rev Med Pharmacol Sci. 2010;14(4):249–58.

    PubMed  Google Scholar 

  8. Maconi G, Manes G, Porro GB. Role of symptoms in diagnosis and outcome of gastric cancer. World J Gastroenterol: WJG. 2008;14(8):1149.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Afaq A, Akin O. Imaging assessment of tumor response: past, present and future. Future Oncol. 2011;7(5):669–77.

    Article  PubMed  Google Scholar 

  10. Hundahl SA, Phillips JL, Menck HR. The National Cancer Data Base report on poor survival of US gastric carcinoma patients treated with gastrectomy. Cancer. 2000;88(4):921–32.

    Article  CAS  PubMed  Google Scholar 

  11. Rodriguez G, Clarke-Pearson D, Soper J, Berchuck A, Synan I, Dodge R. The negative prognostic implications of thrombocytosis in women with stage IB cervical cancer. Obstet Gynecol. 1994;83(3):445–8.

    CAS  PubMed  Google Scholar 

  12. Kemal Y, Yucel I, Ekiz K, Demirag G, Yilmaz B, Teker F, et al. Elevated serum neutrophil to lymphocyte and platelet to lymphocyte ratios could be useful in lung cancer diagnosis. Asian Pac J Cancer Prev. 2014;15(6):2651–4.

    Article  PubMed  Google Scholar 

  13. Ozdemir Y, Akin ML, Sucullu I, Balta AZ, Yucel E. Pretreatment neutrophil/lymphocyte ratio as a prognostic aid in colorectal cancer. Asian Pac J Cancer Prev. 2014;15(6):2647–50.

    Article  PubMed  Google Scholar 

  14. Park Y, Schoene N, Harris W. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets. 2002;13(5–6):301–6.

    Article  CAS  PubMed  Google Scholar 

  15. Fumagalli LA, Vinke J, Hoff W, Ypma E, Brivio F, Nespoli A. Lymphocyte counts independently predict overall survival in advanced cancer patients: a biomarker for IL-2 immunotherapy. J Immunother. 2003;26(5):394–402.

    Article  CAS  PubMed  Google Scholar 

  16. Kilinçalp S, Ekiz F, Basar Ö, Ayte MR, Coban S, Yilmaz B, et al. Mean platelet volume could be possible biomarker in early diagnosis and monitoring of gastric cancer. Platelets. 2013;25(8):592–4.

    Article  PubMed  Google Scholar 

  17. Leader A, Pereg D, Lishner M. Are platelet volume indices of clinical use? A multidisciplinary review. Ann Med. 2012;44(8):805–16.

    Article  PubMed  Google Scholar 

  18. Matowicka-Karna J, Kamocki Z, Polinska B, Osada J, Kemona H. Platelets and inflammatory markers in patients with gastric cancer. Clin Dev Immunol. 2013;2013:401623. PubMed PMID: 23554823. Pubmed Central PMCID: 3608177

    Article  PubMed  PubMed Central  Google Scholar 

  19. Vagdatli E, Gounari E, Lazaridou E, Katsibourlia E, Tsikopoulou F, Labrianou I. Platelet distribution width: a simple, practical and specific marker of activation of coagulation. Hippokratia. 2010;14(1):28.

    CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Oncology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Bakirkoy, Istanbul, Turkey

    Meral Gunaldi

  2. Department of Medical Oncology, Samsun Medical Park Hospital, Samsun, Turkey

    Dilek Erdem

  3. Department of Medical Oncology, Kayseri Education and Research Hospital, Kayseri, Turkey

    Sema Goksu

  4. Department of Medical Oncology, Antalya Education and Research Hospital, Antalya, Turkey

    Seyda Gunduz & Mustafa Yildirim

  5. Department of Internal Medicine, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey

    Yildiz Okuturlar

  6. Department of Radiation Oncology, Bakirkoy Dr. Sadi Konuk Education and Research Hospital, Istanbul, Turkey

    Eda Tiken

  7. Department of General Surgery, GATA Haydarpasa Education Hospital, Istanbul, Turkey

    Huseyin Aksoy

Authors
  1. Meral Gunaldi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Dilek Erdem
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sema Goksu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Seyda Gunduz
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yildiz Okuturlar
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Eda Tiken
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Huseyin Aksoy
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Mustafa Yildirim
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Meral Gunaldi.

Ethics declarations

Ethics Statement

The approval of the Ethics Committee of Bakırköy Dr. Sadi Konuk Education and Research Hospital (no. 2014/09/27, dated 14.07.2014) was received in accordance with the Helsinki Declaration and following the permission of each participating oncology center.

Conflicts of Interest

The authors declare that they have no conflicts of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Gunaldi, M., Erdem, D., Goksu, S. et al. Platelet Distribution Width as a Predictor of Metastasis in Gastric Cancer Patients. J Gastrointest Canc 48, 341–346 (2017). https://doi.org/10.1007/s12029-016-9886-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12029-016-9886-5

Keywords

Search

Navigation