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Long-Term Survival of Patient with Epstein-Barr Virus-Positive Gastric Cancer Treated with Chemotherapy: Case Report

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Fig. 1
Fig. 2

Abbreviations

EBV:

Epstein-Barr virus

GC:

Gastric cancer

EBER1:

Epstein-Barr virus-encoded small RNA1

ISH:

In situ hybridization

References

  1. Hartgrink HH, Jansen EP, van Grieken NC, van de Velde CJ. Gastric cancer. Lancet. 2009;374:477–90.

    Article  PubMed Central  PubMed  Google Scholar 

  2. Burke AP, Yen TS, Shekitka KM, Sobin LH. Lymphoepithelial carcinoma of the stomach with Epstein-Barr virus demonstrated by polymerase chain reaction. Mod Pathol. 1990;3:377–80.

    CAS  PubMed  Google Scholar 

  3. Watanabe H, Enjoji M, Imai T. Gastric carcinoma with lymphoid stroma. Its morphologic characteristics and prognostic correlations. Cancer. 1976;38:232–43.

    Article  CAS  PubMed  Google Scholar 

  4. Yanai H, Nishikawa J, Mizugaki Y, et al. Endoscopic and pathologic features of Epstein-Barr virus-associated gastric carcinoma. Gastrointest Endosc. 1997;45:236–42.

    Article  CAS  PubMed  Google Scholar 

  5. Yanai H, Murakami T, Yoshiyama H, et al. Epstein-Barr virus-associated gastric carcinoma and atrophic gastritis. J Clin Gastroenterol. 1999;29:39–43.

    Article  CAS  PubMed  Google Scholar 

  6. Nishikawa J, Yanai H, Hirano A, et al. High prevalence of Epstein-Barr virus in gastric remnant carcinoma after Billroth-II reconstruction. Scand J Gastroenterol. 2002;37:825–9.

    Article  CAS  PubMed  Google Scholar 

  7. Imai S, Koizumi S, Sugiura M, et al. Gastric carcinoma: monoclonal epithelial malignant cells expressing Epstein-Barr virus latent infection protein. Proc Natl Acad Sci U S A. 1994;91:9131–5.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Iwakiri D, Takada K. Epstein-Barr virus and gastric cancers. In: Robertson ES, editor. Epstein-Barr virus. Norfolk: Caister Academic Press; 2005. p. 157–69.

    Google Scholar 

  9. Murphy G, Pfeiffer R, Camargo MC, Rabkin CS. Meta-analysis shows that prevalence of Epstein-Barr virus-positive gastric cancer differs based on sex and anatomic location. Gastroenterology. 2009;137:824–33.

    Article  PubMed Central  PubMed  Google Scholar 

  10. Camargo MC, Kim WH, Chiaravalli AM, et al. Improved survival of gastric cancer with tumour Epstein-Barr virus positivity: an international pooled analysis. Gut. 2014;63:236–43.

    PubMed Central  PubMed  Google Scholar 

  11. Seo JS, Kim TG, Hong YS, Chen JY, Lee SK. Contribution of Epstein-Barr virus infection to chemoresistance of gastric carcinoma cells to 5-fluorouracil. Arch Pharm Res. 2011;34:635–43.

    Article  CAS  PubMed  Google Scholar 

  12. Wang Q, Tsao SW, Ooka T, et al. Anti-apoptotic role of BARF1 in gastric cancer cells. Cancer Lett. 2006;238:90–103.

    Article  CAS  PubMed  Google Scholar 

  13. Shin HJ, Kim D, Lee SK. Association between Epstein-Barr virus infection and chemoresistance to docetaxel in gastric carcinoma. Mol Cells. 2011;32:173–9.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  14. Tokunaga M, Uemura Y, Tokudome T, et al. Epstein-Barr virus related gastric cancer in Japan: a molecular patho-epidemiological study. Acta Pathol Jpn. 1993;43:574–81.

    CAS  PubMed  Google Scholar 

  15. Seya T, Tanaka N, Yokoi K, et al. Complete response of a patient with advanced gastric cancer, showing Epstein-Barr virus infection, to preoperative chemotherapy with S-1 and cisplatin. Int J Clin Oncol. 2007;12:472–7.

    Article  CAS  PubMed  Google Scholar 

  16. Matsunou H, Konishi F, Hori H, et al. Characteristics of Epstein-Barr virus-associated gastric carcinoma with lymphoid stroma in Japan. Cancer. 1996;77:1998–2004.

    Article  CAS  PubMed  Google Scholar 

  17. Song HJ, Srivastava A, Lee J, et al. Host inflammatory response predicts survival of patients with Epstein-Barr virus-associated gastric carcinoma. Gastroenterology. 2010;139:84–92.

    Article  PubMed  Google Scholar 

  18. Feng WH, Israel B, Raab-Traub N, Busson P, Kenney SC. Chemotherapy induces lytic EBV replication and confers ganciclovir susceptibility to EBV-positive epithelial cell tumors. Cancer Res. 2002;62:1920–6.

    CAS  PubMed  Google Scholar 

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The authors declare that they have no competing interests.

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Correspondence to Hideo Yanai.

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Yanai, H., Yahara, N., Furuya, T. et al. Long-Term Survival of Patient with Epstein-Barr Virus-Positive Gastric Cancer Treated with Chemotherapy: Case Report. J Gastrointest Canc 47, 107–110 (2016). https://doi.org/10.1007/s12029-015-9729-9

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  • DOI: https://doi.org/10.1007/s12029-015-9729-9

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