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Small Bowel Intussusception Due to a Primary Non-Hodgkin's Lymphoma. An Unusual Presentation and Clinical Course

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Abstract

Background/purpose

Adult intussusception is a rare clinical entity accounting for 5% of all intussusceptions. Symptoms and signs are often vague and non-specific making a preoperative diagnosis difficult. The purpose of this study is to present a rare case of a jejuno-jejunal intussusception due to primary intestinal non-Hodgkin's lymphoma in a patient with an unusual clinical course.

Methods

A 78-year-old man presented with a 1-month history of abdominal pain, nausea, epigastric fullness, and weight loss. Computed tomography scan and ultrasonography findings were suggestive of small bowel intussusception.

Results

Laparotomy revealed a jejuno-jejunal intussusception caused by a primary B cell non-Hodgkin's lymphoma 20 cm distal to the ligament of Treitz. Resection without prior reduction was performed. The patient refused postoperative adjuvant chemotherapy. Seven months later, he presented with upper gastrointestinal bleeding, and the diagnostic evaluation revealed gastric infiltration of large B cell non-Hodgkin's lymphoma. Despite chemotherapy, he died of disseminated progressive disease 7 months later.

Conclusions

Adult jejuno-jejunal intussusception due to primary non-Hodgkin's lymphoma is a rare clinical entity. A high index of suspicion is needed as symptoms and signs are not pathognomonic. Appropriate investigations can lead to a prompt preoperative diagnosis. Resection without prior reduction is the treatment of choice. Our patient's refusal of postoperative adjuvant chemotherapy likely resulted in relapse of the disease in another part of the gastrointestinal tract.

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References

  1. Koch P, del Valle F, Berdel WE, Willich NA, Reers B, Hiddemann W, et al. Primary gastrointestinal non-Hodgkin's lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92. German Multicenter Study Group. J Clin Oncol. 2001;19:3861–73.

    CAS  PubMed  Google Scholar 

  2. Li B, Shi YK, He XH, Zou SM, Zhou SY, Dong M, et al. Primary non-Hodgkin lymphomas in the small and large intestine: clinicopathological characteristics and management of 40 patients. Int J Hematol. 2008;87:375–81.

    Article  PubMed  Google Scholar 

  3. Yin I, Chen CQ, Peng CH, Chen GM, Zhou HJ, Han BS, et al. Primary small-bowel non-Hodgkin’s lymphoma: a study of clinical features, pathology, management and prognosis. J Inter Med Res. 2007;35:406–15.

    CAS  Google Scholar 

  4. Ibrahim EM, Ezzat AA, El-Weshi AN, Martin JM, Khafaga YM, Al Rabih W, et al. Primary intestinal diffuse large B-cell non-Hodgkin's lymphoma: clinical features, management, and prognosis of 66 patients. Ann Oncol. 2001;12:53–8.

    Article  CAS  PubMed  Google Scholar 

  5. Scheri R, Drebin JA. Tumors of the small intestine. In: Cameron J, editor. Current surgical therapy. 9th ed. Philadelphia: Elsevier Mosby; 2004. p. 120–4.

    Google Scholar 

  6. Zinzani PL, Magagnoli M, Pagliani G, Bendandi M, Gherlinzoni F, Merla E, et al. Primary intestinal lymphoma: clinical and therapeutic features of 32 patients. Haematologica. 1997;82:305–8.

    CAS  PubMed  Google Scholar 

  7. Lee J, Kim WS, Kim K, Ko YH, Kim JJ, Kim YH, et al. Intestinal lymphoma: exploration of the prognostic factors and the optimal treatment. Leuk Lymphoma. 2004;45:339–44.

    Article  PubMed  Google Scholar 

  8. Houghton JM, Wang TC. Tumors of the stomach. In: Feldman M, Friedman LS, Sleisenger MH, editors. Sleisenger and Fordtran's gastrointestinal and liver disease. 8th ed. Philadelphia: Saunders Elsevier; 2006. p. 1139–70.

    Google Scholar 

  9. Gollub MJ. Imaging of gastrointestinal lymphoma. Radiol Clin N Am. 2008;46:287–312.

    Article  PubMed  Google Scholar 

  10. Salemis NS, Gourgiotis S, Tsiambas E, Karagkiouzis G, Nakos G, Karathanasis V. Diffuse large B cell lymphoma of the mesentery: an unusual presentation and review of the literature. J Gastrointest Cancer. 2009;40(3–4):79–82.

    Article  PubMed  Google Scholar 

  11. Myung SJ, Joo KR, Yang SK, Jung HY, Chang HS, Lee HJ, et al. Clinicopathologic features of ileocolonic malignant lymphoma: analysis according to colonoscopic classification. Gastrointest Endosc. 2003;57:343–7.

    Article  PubMed  Google Scholar 

  12. Gobbi PG, Ghirardelli ML, Cavalli C, Baldini L, Broglia C, Clò V, et al. The role of surgery in the treatment of gastrointestinal lymphomas other than low-grade MALT lymphomas. Haematologica. 2000;85:372–80.

    CAS  PubMed  Google Scholar 

  13. d'Amore F, Brincker H, Grønbaek K, Thorling K, Pedersen M, Jensen MK, et al. Non-Hodgkin's lymphoma of the gastrointestinal tract: a population-based analysis of incidence, geographic distribution, clinicopathologic presentation features, and prognosis. Danish Lymphoma Study Group. J Clin Oncol. 1994;12:1673–84.

    PubMed  Google Scholar 

  14. Eisen LK, Cunningham JD, Aufses Jr AH. Intussusception in adults: institutional review. J Am Coll Surg. 1999;188:390–5.

    Article  CAS  PubMed  Google Scholar 

  15. Azar T, Berger DL. Adult intussusception. Ann Surg. 1997;226:134–8.

    Article  CAS  PubMed  Google Scholar 

  16. Barussaud M, Regenet N, Briennon X, de Kerviler B, Pessaux P, Kohneh-Sharhi N, et al. Clinical spectrum and surgical approach of adult intussusceptions: a multicentric study. Int J Colorectal Dis. 2006;21:834–9.

    Article  CAS  PubMed  Google Scholar 

  17. Weilbaecher D, Bolin JA, Hearn D, Ogden 2nd W. Intussusception in adults. Review of 160 cases. Am J Surg. 1971;121:531–5.

    Article  CAS  PubMed  Google Scholar 

  18. Begos DG, Sandor A, Modlin IM. The diagnosis and management of adult intussusception. Am J Surg. 1997;173:88–94.

    Article  CAS  PubMed  Google Scholar 

  19. Nagorney DM, Sarr MG, McIlrath DC. Surgical management of intussusception in the adult. Ann Surg. 1981;193:230–6.

    Article  CAS  PubMed  Google Scholar 

  20. Zubaidi A, Al-Saif F, Silverman R. Adult intussusception: a retrospective review. Dis Colon Rectum. 2006;49:1546–51.

    Article  PubMed  Google Scholar 

  21. Chiang JM, Lin YS. Tumor spectrum of adult intussusception. J Surg Oncol. 2008;98:444–7.

    Article  PubMed  Google Scholar 

  22. Gayer G, Apter S, Hofmann C, Nass S, Amitai M, Zissin R, et al. Intussusception in adults: CT diagnosis. Clin Radiol. 1998;53:53–7.

    Article  CAS  PubMed  Google Scholar 

  23. Cerro P, Magrini L, Porcari P, De Angelis O. Sonographic diagnosis of intussusception in adults. Abdom Imaging. 2000;25:45–7.

    Article  CAS  PubMed  Google Scholar 

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The authors declare that they have no conflict of interest.

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Correspondence to Nikolaos S. Salemis.

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Salemis, N.S., Tsiambas, E., Liatsos, C. et al. Small Bowel Intussusception Due to a Primary Non-Hodgkin's Lymphoma. An Unusual Presentation and Clinical Course. J Gastrointest Canc 41, 233–237 (2010). https://doi.org/10.1007/s12029-010-9152-1

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