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Transfusion-Related Acute Lung Injury After IVIG for Myasthenic Crisis

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Abstract

Background

A 26-year-old female with myasthenic crisis developed transfusion-related acute lung injury (TRALI) after she was treated with intravenous immunoglobulin.

Methods

Case report.

Results

Respiratory status markedly worsened with each intravenous immunoglobulin (IVIG) administration and progressing from a need to use bilevel positive airway pressure (BiPAP) to intubation. Pulmonary function tests improved during this episode.

Conclusions

IVIG may cause TRALI and due to subtle clinical findings can be mistaken for neuromuscular respiratory failure.

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Author information

Authors and Affiliations

  1. Division of Pulmonary and Critical Care Medicine, Mayo Clinic, 200 First Street SW RO_OL_2_115CCS, Rochester, MN, 55905, USA

    Dereddi Raja S. Reddy & Pramod K. Guru

  2. Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

    Melissa M. Blessing & James R. Stubbs

  3. Division of Critical Care Neurology, Mayo, Rochester, MN, USA

    Alejandro A. Rabinstein & Eelco F. M. Wijdicks

Authors
  1. Dereddi Raja S. Reddy
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  2. Pramod K. Guru
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  3. Melissa M. Blessing
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  4. James R. Stubbs
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  5. Alejandro A. Rabinstein
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  6. Eelco F. M. Wijdicks
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Corresponding author

Correspondence to Dereddi Raja S. Reddy.

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Reddy, D.R.S., Guru, P.K., Blessing, M.M. et al. Transfusion-Related Acute Lung Injury After IVIG for Myasthenic Crisis. Neurocrit Care 23, 259–261 (2015). https://doi.org/10.1007/s12028-015-0115-z

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  • DOI: https://doi.org/10.1007/s12028-015-0115-z

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