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Big data highlights the association between psoriasis and fibromyalgia: a population-based study

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Abstract

Data on the association between fibromyalgia syndrome (FMS) and psoriasis are scarce. We aimed to examine the association between FMS and psoriasis using a large-scale observational population-based study. This cross-sectional study analyzed data from a big computerized database to evaluate potential differences in the prevalence of psoriasis between patients with FMS and matched control subjects. The study included 18,598 patients with FMS and 36,985 controls. The prevalence of psoriasis was increased in patients with FMS as compared with control subjects (6.7% vs. 4.8%, respectively; OR, 1.4; 95% CI, 1.3–1.5; P < 0.001). This association was robust to multivariate analysis adjustment for sex, age, ancestry, socioeconomic status, and healthcare utilization (OR, 1.3; 95% CI, 1.2–1.4; P < 0.001). When compared with patients with only FMS, patients with a dual diagnosis of FMS and psoriasis presented with FMS at a significantly older age, had a higher mean BMI, and a higher frequency of smoking. To conclude, we found a significant association between FMS and psoriasis. More extensive cooperation between dermatologists and rheumatologists is suggested to enable early identification of their co-occurrence.

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Funding

G.D. was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases [P50 AR 070590 01A1].

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Authors and Affiliations

  1. Lűbeck Institute of Experimental Dermatology, University of Lűbeck, Lűbeck, Germany

    K. Kridin

  2. Ruth and Bruce Rappaport Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel

    S. Vanetik

  3. Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA

    G. Damiani

  4. Young Dermatologists Italian Network, GISED, Bergamo, Italy

    G. Damiani

  5. Clinical Dermatology, IRCCS Istituto Ortopedico Galeazzi, Milan, Italy

    G. Damiani

  6. Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy

    G. Damiani

  7. Department of Quality Measurements and Research, Chief Physician’s Office, Clalit Health Service, Tel Aviv, Israel

    A. D. Cohen

  8. Siaal Research Center for Family Medicine and Primary Care, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    A. D. Cohen

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  1. K. Kridin
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  2. S. Vanetik
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  3. G. Damiani
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  4. A. D. Cohen
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Correspondence to K. Kridin.

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Kridin, K., Vanetik, S., Damiani, G. et al. Big data highlights the association between psoriasis and fibromyalgia: a population-based study. Immunol Res 68, 135–140 (2020). https://doi.org/10.1007/s12026-020-09135-7

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  • DOI: https://doi.org/10.1007/s12026-020-09135-7

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