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Role of T cell-derived exosomes in immunoregulation

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Abstract

Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells. They are composed of a lipid bilayer containing transmembrane proteins and enclosing cytosolic proteins and RNA, mediating intercellular communication between different cell types in the body, and thus influencing various physiological and pathological functions of both recipient and parent cells. For their nanolevel structures with a stable nature and various biological functions, studies of exosomes have been the subject of increasing interest in the past few years. It is widely known that different T cell subsets play important roles in cellular and humoral immunity, and their exosomes were also reported to exert similar biological functions. While several groups reported the secretion of exosomes by various T cells, the systematic summary involved in these exosomes are deficient. In this review, we will summarize the structure and functions of exosomes derived from T cells in recent reports, discuss emerging therapeutic opportunities, and consider the associated challenges.

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Funding

This work was supported by the National Natural Science Foundation of China (Grant Nos. 81771759, 31470881, 31711530025), Natural Science Foundation of Jiangsu (Grant No. BK20150533), Project funded by China Postdoctoral Science Foundation (Grant Nos. 2016 M590423, 2017 T100336), Jiangsu Province’s Key Medical Talents Program (Grant No. ZDRCB2016018), Summit of the Six Top Talents Program of Jiangsu Province (Grant No. 2015-WSN-116), and Jiangsu Province “333” Project (Grant No. BRA2017128).

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Authors and Affiliations

  1. Department of Laboratory Medicine, The Affiliated People’s Hospital, Jiangsu University, Dianli Road No. 8, Zhenjiang, 212012, China

    Jian Lu, Jing Wu & Shengjun Wang

  2. Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, China

    Jian Lu, Jing Wu, Jie Tian & Shengjun Wang

  3. Institute of Laboratory Medicine, Jiangsu University School of Medicine, Zhenjiang, 212013, China

    Jie Tian

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  1. Jian Lu
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  2. Jing Wu
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JL discussed the ideas, wrote, and discussed the text with other authors. JW and JT discussed the text with other authors. SW conceived the idea and topic of the review, read, and made suggestions in the final text.

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Correspondence to Jie Tian or Shengjun Wang.

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Lu, J., Wu, J., Tian, J. et al. Role of T cell-derived exosomes in immunoregulation. Immunol Res 66, 313–322 (2018). https://doi.org/10.1007/s12026-018-9000-0

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