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Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire

  • Immunology in Colorado
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Abstract

Immature B cells are generated daily in the bone marrow tissue. More than half of the newly generated immature B cells are autoreactive and bind a self-antigen, while the others are nonautoreactive. A selection process has evolved on the one hand to thwart development of autoreactive immature B cells and, on the other hand, to promote further differentiation of nonautoreactive immature B cells into transitional and mature B cells. These negative and positive selection events are carefully regulated by signals that emanate from the antigen receptor, whether antigen-mediated or tonic, and are influenced by signals that are generated by receptors that bind cytokines, chemokines, and other factors produced in the bone marrow tissue. These signals, therefore, are the predominant driving forces for the generation of a B cell population that is capable of protecting the body from infections while maintaining self-tolerance. Here, we review recent findings from our group and others that describe how tonic antigen receptor signaling and bone marrow cytokines regulate the selection of immature B cells.

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Acknowledgments

We thank present and past members of our laboratories who have contributed to the work and discussions presented here. Work in the authors’ laboratory was and/or is supported by the National Institutes of Health grants AI022295, AI052310, AI052157, AI078468, the Arthritis Foundation and a Cancer Research Institute Pre-Doctoral training grant.

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  1. Integrated Department of Immunology, University of Colorado School of Medicine, National Jewish Health, Denver, CO, USA

    Sarah L. Rowland, Kathryn Tuttle, Raul M. Torres & Roberta Pelanda

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  1. Sarah L. Rowland
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  2. Kathryn Tuttle
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Correspondence to Roberta Pelanda.

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Rowland, S.L., Tuttle, K., Torres, R.M. et al. Antigen and cytokine receptor signals guide the development of the naïve mature B cell repertoire. Immunol Res 55, 231–240 (2013). https://doi.org/10.1007/s12026-012-8366-7

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