Skip to main content

Advertisement

Log in

A tribute to Ernest L. Mazzaferri, MD and the lasting impact that he had on thyroid cancer care ten years after his death

  • Viewpoint
  • Published:
Endocrine Aims and scope Submit manuscript

Abstract

This viewpoint highlights the contributions of Dr. Ernest Mazzaferri, a prominent figure in the field of thyroid cancer care, who made significant contributions to the diagnosis and treatment of this disease. Dr. Mazzaferri’s first paper on thyroid cancer, published in 1977, established fundamental principles that remain fundamental to differentiated thyroid cancer management. He was an advocate of total thyroidectomy and of postoperative radioiodine therapy and contributed to improving thyroid fine needle aspiration techniques. Dr. Mazzaferri’s leadership in developing guidelines for the management of thyroid cancer and thyroid nodules has been influential and widely accepted. His groundbreaking work established a systematic and data-driven approach to the diagnosis and treatment of thyroid cancer that continues to shape the field of thyroid cancer care today. This Viewpoint reflects on his lasting impact ten years after his death.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. S.C. Werner, S.H. Ingbar. The Thyroid: A Fundamental and Clinical Text. 3rd ed. (Harper & Row, New York, 1971).

    Google Scholar 

  2. E.L. Mazzaferri, R.L. Young, J.E. Oertel, W.T. Kemmerer, C.P. Page, Papillary thyroid carcinoma: the impact of therapy in 576 patients. Medicine 56(3), 171–196 (1977).

    Article  CAS  PubMed  Google Scholar 

  3. E.L. Mazzaferri, S.M. Jhiang, Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am. J. Med 97(5), 418–428 (1994). https://doi.org/10.1016/0002-9343(94)90321-2.

    Article  CAS  PubMed  Google Scholar 

  4. N.A. Samaan, P.N. Schultz, R.C. Hickey et al. The results of various modalities of treatment of well differentiated thyroid carcinomas: a retrospective review of 1599 patients. J. Clin. Endocrinol. Metab. 75(3), 714–720 (1992). https://doi.org/10.1210/jcem.75.3.1517360.

    Article  CAS  PubMed  Google Scholar 

  5. B.R. Haugen, F. Pacini, C. Reiners et al. A comparison of recombinant human thyrotropin and thyroid hormone withdrawal for the detection of thyroid remnant or cancer. J. Clin. Endocrinol. Metab. 84(11), 3877–3885 (1999). https://doi.org/10.1210/jcem.84.11.6094.

    Article  CAS  PubMed  Google Scholar 

  6. E.L. Mazzaferri, R.J. Robbins, C.A. Spencer et al. A consensus report of the role of serum thyroglobulin as a monitoring method for low-risk patients with papillary thyroid carcinoma. J. Clin. Endocrinol. Metab. 88(4), 1433–1441 (2003). https://doi.org/10.1210/jc.2002-021702.

    Article  CAS  PubMed  Google Scholar 

  7. E.L. Mazzaferri, Management of a solitary thyroid nodule. N. Engl. J. Med. 328(8), 553–559 (1993). https://doi.org/10.1056/NEJM199302253280807.

    Article  CAS  PubMed  Google Scholar 

  8. R. Redman, H. Zalaznick, E.L. Mazzaferri, N.A. Massoll, The impact of assessing specimen adequacy and number of needle passes for fine-needle aspiration biopsy of thyroid nodules. Thyroid 16(1), 55–60 (2006). https://doi.org/10.1089/thy.2006.16.55.

    Article  PubMed  Google Scholar 

  9. E. Mazzaferri, Fine-needle aspiration biopsy, ultrasound and BRAF(V600E) analysis - is this the best FNAB combination for most patients? Clin. Endocrinol. 75(6), 740–742 (2011). https://doi.org/10.1111/j.1365-2265.2011.04245.x.

    Article  CAS  Google Scholar 

  10. L. Davies, H.G. Welch, Increasing incidence of thyroid cancer in the United States, 1973–2002. JAMA 295(18), 2164–2167 (2006). https://doi.org/10.1001/jama.295.18.2164.

    Article  CAS  PubMed  Google Scholar 

  11. E.L. Mazzaferri, Managing small thyroid cancers. JAMA 295(18), 2179–2182 (2006). https://doi.org/10.1001/jama.295.18.2179.

    Article  CAS  PubMed  Google Scholar 

  12. C.M. Kitahara, J.A. Sosa, Understanding the ever-changing incidence of thyroid cancer. Nat. Rev. Endocrinol. 16(11), 617–618 (2020). https://doi.org/10.1038/s41574-020-00414-9.

    Article  PubMed  PubMed Central  Google Scholar 

  13. R. Chou, T. Dana, M. Haymart, A.M. Leung, R.P. Tufano, J.A. Sosa, M.D. Ringel, Active surveillance versus thyroid surgery for differentiated thyroid cancer: a systematic review. Thyroid 32(4), 351–367 (2022). https://doi.org/10.1089/thy.2021.0539.

    Article  CAS  PubMed  Google Scholar 

  14. R.T. Kloos, J.A. Sipos, M. Tzagournis, L. Ernest, M.D. Mazzaferri et al. MACP (1936–2013). Thyroid 23(8), 917–923 (2013). https://doi.org/10.1089/thy.2013.2308.ob.

    Article  PubMed  Google Scholar 

  15. D.S. Cooper, G.M. Doherty, B.R. Haugen et al. American Thyroid Association Guidelines Taskforce. Management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 16(2), 109–142 (2006). https://doi.org/10.1089/thy.2006.16.109.

    Article  PubMed  Google Scholar 

  16. D.S. Cooper, G.M. Doherty, B.R. Haugen et al. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19(11), 1167–1214 (2009). https://doi.org/10.1089/thy.2009.0110.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to David S. Cooper.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Additional information

Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cooper, D.S., Ringel, M.D. A tribute to Ernest L. Mazzaferri, MD and the lasting impact that he had on thyroid cancer care ten years after his death. Endocrine 80, 500–502 (2023). https://doi.org/10.1007/s12020-023-03385-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12020-023-03385-9

Keywords

Navigation