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Dynamic changes in the distribution of facial and abdominal adipose tissue correlated with surgical treatment in acromegaly

  • Endocrine Surgery
  • Published:
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Abstract

Purpose

Acromegaly is a systemic metabolic disease. Growth hormone (GH) have a significant impact on adipose tissue (AT). A huge reduction of serum GH after surgical treatment may cause substantial AT redistribution. The objective of this study was to illustrate the dynamic changes in distribution of facial and abdominal AT correlated with surgical treatment in patients with acromegaly.

Methods

Abdominal AT in 17 acromegaly patients (group 1) was studied longitudinally preoperatively and 1 month to 1 year postoperatively. The facial and abdominal subcutaneous AT (fSAT and aSAT) of another 17 acromegaly patients (group 2) were compared with 7 nonfunctional pituitary adenoma (NFPA) controls.

The areas of fSAT, aSAT, and visceral adipose tissue (VAT) were obtained by MRI and quantified by image analysis software, and intrahepatic lipid (IHL) was assessed by 1H magnetic resonance spectroscopy (MRS).

Results

Abdominal adipose tissue (aSAT, VAT, and IHL) increased overall after surgical treatment. However, IHL first decreased and then continuously increased during the follow-up. Compared with the increased amount of aSAT, the fSAT amount decreased after surgical treatment. The inconsistency of this phenomenon did not appear in the NFPA control subjects.

Conclusion

The perioperative dynamic distribution of the facial and abdominal fat in acromegaly revealed regional differences in the intricate effect of GH on adipose tissue. Reduction of serum GH after surgical treatment of acromegaly was associated with dynamic increases of IHL, abdominal visceral, and subcutaneous fat, but a reduction of facial subcutaneous fat.

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Acknowledgements

We thank and acknowledge all of the participants in the study. We gratefully thank TianPei for interpretation to the patients.

Funding

This study was funded by the National Key Research and Development Program of China (grant number: 2016YFC0106103).

Author information

Author notes

  1. These authors contributed equally: Tao Xie, Hailin Ding, Mingfeng Xia.

Authors and Affiliations

  1. Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China

    Tao Xie, Xiaobiao Zhang, Tengfei Liu, Ye Gu, Chongjing Sun & Fan Hu

  2. Department of Emergency, Zhongshan Hospital, Fudan University, Shanghai, China

    Hailin Ding

  3. Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China

    Mingfeng Xia

  4. Digital Medical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China

    Xiaobiao Zhang

  5. Shanghai Key Laboratory of Medical Image Computing and Computer-Assisted Intervention, Shanghai, China

    Xiaobiao Zhang

  6. Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China

    Wei Sun

Authors
  1. Tao Xie
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  2. Hailin Ding
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  3. Mingfeng Xia
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  4. Xiaobiao Zhang
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  5. Wei Sun
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  7. Ye Gu
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Corresponding author

Correspondence to Xiaobiao Zhang.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

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Xie, T., Ding, H., Xia, M. et al. Dynamic changes in the distribution of facial and abdominal adipose tissue correlated with surgical treatment in acromegaly. Endocrine 62, 552–559 (2018). https://doi.org/10.1007/s12020-018-1742-x

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  • DOI: https://doi.org/10.1007/s12020-018-1742-x

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