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A pathogenetic link between non-alcoholic fatty liver disease and celiac disease

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Abstract

Non-alcoholic fatty liver disease (NAFLD) has recently been recognized as the leading cause of the abnormalities in the liver function tests in the Western countries. Celiac disease (CD) is a permanent immunological intolerance to gluten proteins in genetically predisposed individuals. CD has been reported in 4–13 % of the cases with steatohepatitis, although the pathogenesis of the liver steatosis in CD patients is unclear. Based on the literature data, it can be concluded that the inclusion of serological markers of CD should be a part of the general workup in the patients with steatosis when other causes of the liver disease are excluded and in the patients with NAFLD when metabolic risk factors are not evident.

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Conflict of interest

The authors declare that they have no competing interests.

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Authors and Affiliations

  1. Department of Health Sciences, University “Magna Græcia”, Viale Europa, 88100, Catanzaro, Italy

    Ludovico Abenavoli & Francesco Luzza

  2. Department of Pharmacy, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia

    Natasa Milic

  3. Department of Neuroscience, Division of Human Nutrition, University “Tor Vergata”, Via Montpellier n.1, 00133, Rome, Italy

    Antonino De Lorenzo

Authors
  1. Ludovico Abenavoli
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  2. Natasa Milic
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  3. Antonino De Lorenzo
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  4. Francesco Luzza
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Correspondence to Ludovico Abenavoli.

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Abenavoli, L., Milic, N., De Lorenzo, A. et al. A pathogenetic link between non-alcoholic fatty liver disease and celiac disease. Endocrine 43, 65–67 (2013). https://doi.org/10.1007/s12020-012-9731-y

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  • DOI: https://doi.org/10.1007/s12020-012-9731-y

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