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The association of TAAAAn repeat polymorphism in sex hormone-binding protein gene with polycystic ovary syndrome in Chinese population

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Abstract

TAAAAn polymorphism in sex hormone-binding globulin (SHBG) gene has been found to influence the transcriptional activity of SHBG gene in vitro, and several studies have reported variable associations of this polymorphism with serum SHBG levels in women with polycystic ovary syndrome (PCOS). We have investigated the association of TAAAAn polymorphism with PCOS in 187 women with PCOS and 176 controls; in which five alleles (6–10 repeats) and 13 genotypes were found. None of the TAAAAn alleles or genotypes occurred in significant different frequency in PCOS patients compared with controls. Serum SHBG in the PCOS group was significantly lower than those in controls (33.8 ± 30.2 nmol/l vs. 65.58 ±  31.12 nmol/l; P < 0.01). Serum SHBG concentrations were similar for patients with PCOS whether they displayed short or long genotypes for TAAAAn (Log10SHBG: 1.46 ± 0.38 and 1.58 ± 0.33, respectively). Similar results were observed for controls (Log10SHBG: 1.79 ± 0.17 and 1.77 ± 0.14, respectively). In contrast, serum SHBG values were negatively associated with body mass index (BMI) and homeostasis model assessment of insulin resistance in the PCOS group (B = −0.285 and −0.264, respectively; P < 0.01). Thus, the TAAAAn polymorphism in SHBG gene was not a determinant of PCOS in this population of Chinese women, whereas, serum SHBG was significantly associated with BMI and insulin resistance in these PCOS patients.

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Acknowledgment

This study would not have been possible without the participation of the patients and volunteers from Shanghai. This research was supported by grants from Shanghai Education Commission (E03007) and Shanghai Leading Academic Discipline Project (Project no. Y0204).

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Authors and Affiliations

  1. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, 197 RuiJin Er Lu, Shanghai, 200025, People’s Republic of China

    Qiaorui Liu, Weiqiong Gu, Bin Cui, Jie Hong, Yifei Zhang, Zhenni Chi, Yuxia Su & Guang Ning

  2. Laboratory Endocrine & Metabolic Diseases of Institute of Health Science, Shanghai JiaoTong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 225 South ChongQing Road, Shanghai, 200025, People’s Republic of China

    Qiaorui Liu, Bin Cui & Guang Ning

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  1. Qiaorui Liu
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  2. Weiqiong Gu
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  4. Jie Hong
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Correspondence to Jie Hong.

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Qiaorui Liu and Weiqiong Gu contributed equally to this work.

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Liu, Q., Gu, W., Cui, B. et al. The association of TAAAAn repeat polymorphism in sex hormone-binding protein gene with polycystic ovary syndrome in Chinese population. Endocr 34, 62–67 (2008). https://doi.org/10.1007/s12020-008-9104-8

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  • DOI: https://doi.org/10.1007/s12020-008-9104-8

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