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The A946T polymorphism in the interferon induced helicase gene does not confer susceptibility to Graves’ disease in Chinese population

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Abstract

Genetic susceptibility plays a major role in the etiology of Graves’ disease (GD). A recent study revealed that the A946T polymorphism (rs1990760) in interferon induced helicase (IFIH1) gene was a susceptible locus for GD. A case-control study in a Chinese population was undertaken, with 261 GD patients and 206 healthy subjects, to analyze the association of A946T polymorphism in IFIH1 gene with GD. In addition, the distribution of IFIH1 genotypes was investigated in subgroups according to the onset age and the Graves’ ophthalmopathy (GO). No significant differences in the allele and genotype frequencies for A946T polymorphism were found between GD patients and healthy controls (χ 2 = 2.834, P = 0.242; χ 2 = 1.127, P = 0.288). The genotype–phenotype correlation was not identified either. Therefore we were unable to find the association of A946T polymorphism of the IFIH1 gene with the development of GD in a Chinese population.

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Acknowledgments

The present study would not have been possible without the participation of the patients and healthy volunteers. The study is supported by the grants from the National Nature Science Foundation of China (No. 30370666).

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Authors and Affiliations

  1. Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, 197 Ruijin Er Lu, Shanghai, 200025, P.R. China

    Ze-Fei Zhao, Bin Cui, Hao-Yan Chen, Shu Wang, Imelda Li, Xue-Jiang Gu, Li Qi, Xiao-Ying Li, Guang Ning & Yong-Ju Zhao

  2. Laboratory of Endocrine and Metabolic Diseases, Institute of Health Sciences, Shanghai JiaoTong University School of Medicine and Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, P.R. China

    Ze-Fei Zhao, Bin Cui, Hao-Yan Chen, Shu Wang, Xue-Jiang Gu, Li Qi, Xiao-Ying Li & Guang Ning

  3. Department of Geriatrics, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, P.R. China

    Yong-Ju Zhao

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  1. Ze-Fei Zhao
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Correspondence to Yong-Ju Zhao.

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The authors Ze-Fei Zhao and Bin Cui have contributed equally to this work.

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Zhao, ZF., Cui, B., Chen, HY. et al. The A946T polymorphism in the interferon induced helicase gene does not confer susceptibility to Graves’ disease in Chinese population. Endocr 32, 143–147 (2007). https://doi.org/10.1007/s12020-007-9024-z

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  • DOI: https://doi.org/10.1007/s12020-007-9024-z

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