Skip to main content

Advertisement

SpringerLink
Log in

Atopy and Specific Cancer Sites: a Review of Epidemiological Studies

  • Published:
Clinical Reviews in Allergy & Immunology Aims and scope Submit manuscript

Abstract

Mounting evidence appears to link asthma and atopy to cancer susceptibility. This review presents and discusses published epidemiological studies on the association between site-specific cancers and atopy. PubMed was searched electronically for publications between 1995 and 2015, and cited references were researched manually. Quantitative studies relating to atopy, allergy, or asthma and cancer were identified and tabulated. Despite many exposure-related limitations, patterns in the studies were observed. Asthma, specifically, has been observed to be a risk factor for lung cancer. A protective effect of atopic diseases against pancreatic cancer has been shown consistently in case-control studies but not in cohort studies. Allergy of any type appears to be protective against glioma and adult acute lymphoblastic leukemia. Most studies on atopic diseases and non-Hodgkin lymphoma or colorectal cancer reported an inverse association. The other sites identified had varying and non-significant outcomes. Further research should be dedicated to carefully defined exposure assessments of “atopy” as well as the biological plausibility in the association between atopic diseases and cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Akinbami LJ, Moorman JE, Bailey C, Zahran HS, King M, Johnson CA, Liu X (2012) Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS Data Brief (94):1–8

  2. Sicherer SH, Munoz-Furlong A, Godbold JH, Sampson HA (2010) US prevalence of self-reported peanut, tree nut, and sesame allergy: 11-year follow-up. J Allergy Clin Immunol 125(6):1322–1326. doi:10.1016/j.jaci.2010.03.029

    Article  CAS  PubMed  Google Scholar 

  3. Singh K, Axelrod S, Bielory L (2010) The epidemiology of ocular and nasal allergy in the United States, 1988–1994. J Allergy Clin Immunol 126(4):778–783 . doi:10.1016/j.jaci.2010.06.050 e776

    Article  PubMed  Google Scholar 

  4. Asher I, Pearce N (2014) Global burden of asthma among children. Int J Tuberc Lung Dis 18(11):1269–1278. doi:10.5588/ijtld.14.0170

    Article  CAS  PubMed  Google Scholar 

  5. Masoli M, Fabian D, Holt S, Beasley R (2004) The global burden of asthma: executive summary of the GINA Dissemination Committee report. Allergy 59(5):469–478. doi:10.1111/j.1398-9995.2004.00526.x

    Article  PubMed  Google Scholar 

  6. Nutten S (2015) Atopic dermatitis: global epidemiology and risk factors. Ann Nutr Metab 66(Suppl 1):8–16. doi:10.1159/000370220

    Article  CAS  PubMed  Google Scholar 

  7. Chai EZ, Siveen KS, Shanmugam MK, Arfuso F, Sethi G (2015) Analysis of the intricate relationship between chronic inflammation and cancer. Biochem J 468(1):1–15. doi:10.1042/bj20141337

    Article  CAS  PubMed  Google Scholar 

  8. Echchakir H, Mami-Chouaib F, Vergnon I, Baurain JF, Karanikas V, Chouaib S, Coulie PG (2001) A point mutation in the alpha-actinin-4 gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human lung carcinoma. Cancer Res 61(10):4078–4083

    CAS  PubMed  Google Scholar 

  9. Engels EA, Pfeiffer RM, Fraumeni JF Jr, Kasiske BL, Israni AK, Snyder JJ, Wolfe RA, Goodrich NP, Bayakly AR, Clarke CA, Copeland G, Finch JL, Fleissner ML, Goodman MT, Kahn A, Koch L, Lynch CF, Madeleine MM, Pawlish K, Rao C, Williams MA, Castenson D, Curry M, Parsons R, Fant G, Lin M (2011) Spectrum of cancer risk among US solid organ transplant recipients. JAMA 306(17):1891–1901. doi:10.1001/jama.2011.1592

  10. Engels EA, Pfeiffer RM, Goedert JJ, Virgo P, McNeel TS, Scoppa SM, Biggar RJ (2006) Trends in cancer risk among people with AIDS in the United States 1980–2002. AIDS 20(12):1645–1654. doi:10.1097/01.aids.0000238411.75324.59

    Article  PubMed  Google Scholar 

  11. Grulich AE, van Leeuwen MT, Falster MO, Vajdic CM (2007) Incidence of cancers in people with HIV/AIDS compared with immunosuppressed transplant recipients: a meta-analysis. Lancet 370(9581):59–67. doi:10.1016/s0140-6736(07)61050-2

    Article  PubMed  Google Scholar 

  12. Hogan KT, Eisinger DP, Cupp SB 3rd, Lekstrom KJ, Deacon DD, Shabanowitz J, Hunt DF, Engelhard VH, Slingluff CL Jr, Ross MM (1998) The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated elongation factor 2 gene. Cancer Res 58(22):5144–5150

  13. Karanikas V, Colau D, Baurain JF, Chiari R, Thonnard J, Gutierrez-Roelens I, Goffinet C, Van Schaftingen EV, Weynants P, Boon T, Coulie PG (2001) High frequency of cytolytic T lymphocytes directed against a tumor-specific mutated antigen detectable with HLA tetramers in the blood of a lung carcinoma patient with long survival. Cancer Res 61(9):3718–3724

    CAS  PubMed  Google Scholar 

  14. Shiels MS, Engels EA (2012) Increased risk of histologically defined cancer subtypes in human immunodeficiency virus-infected individuals: clues for possible immunosuppression-related or infectious etiology. Cancer 118(19):4869–4876. doi:10.1002/cncr.27454

    Article  PubMed  PubMed Central  Google Scholar 

  15. Wang RF, Wang X, Atwood AC, Topalian SL, Rosenberg SA (1999a) Cloning genes encoding MHC class II-restricted antigens: mutated CDC27 as a tumor antigen. Science 284(5418):1351–1354

    Article  CAS  PubMed  Google Scholar 

  16. Wang RF, Wang X, Rosenberg SA (1999b) Identification of a novel major histocompatibility complex class II-restricted tumor antigen resulting from a chromosomal rearrangement recognized by CD4(+) T cells. J Exp Med 189(10):1659–1668

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Anderson LN, Cotterchio M, Gallinger S (2009) Lifestyle, dietary, and medical history factors associated with pancreatic cancer risk in Ontario, Canada. Cancer Causes & Control: CCC 20(6):825–834. doi:10.1007/s10552-009-9303-5

    Article  PubMed  PubMed Central  Google Scholar 

  18. Brenner AV, Linet MS, Fine HA, Shapiro WR, Selker RG, Black PM, Inskip PD (2002) History of allergies and autoimmune diseases and risk of brain tumors in adults. Int J Cancer 99(2):252–259. doi:10.1002/ijc.10320

    Article  CAS  PubMed  Google Scholar 

  19. Brenner AV, Wang Z, Kleinerman RA, Wang L, Zhang S, Metayer C, Chen K, Lei S, Cui H, Lubin JH (2001) Previous pulmonary diseases and risk of lung cancer in Gansu Province, China. Int J Epidemiol 30(1):118–124

    Article  CAS  PubMed  Google Scholar 

  20. Briggs NC, Levine RS, Brann EA (2002) Allergies and risk of non-Hodgkin’s lymphoma by subtype. Cancer Epidemiol Biomark Prev 11(4):401–407

    Google Scholar 

  21. Brown DW, Young KE, Anda RF, Felitti VJ, Giles WH (2006) Re: asthma and the risk of lung cancer. Findings from the Adverse Childhood Experiences (ACE). Cancer Causes & Control: CCC 17(3):349–350. doi:10.1007/s10552-005-0420-5

    Article  PubMed  Google Scholar 

  22. Brownson RC, Alavanja MC (2000) Previous lung disease and lung cancer risk among women (United States). Cancer Causes & Control: CCC 11(9):853–858

    Article  CAS  PubMed  Google Scholar 

  23. Calboli FC, Cox DG, Buring JE, Gaziano JM, Ma J, Stampfer M, Willett WC, Tworoger SS, Hunter DJ, Camargo CA Jr, Michaud DS (2011) Prediagnostic plasma IgE levels and risk of adult glioma in four prospective cohort studies. J Natl Cancer Inst 103(21):1588–1595. doi:10.1093/jnci/djr361

  24. Chang JS, Tsai YW, Tsai CR, Wiemels JL (2012) Allergy and risk of childhood acute lymphoblastic leukemia: a population-based and record-based study. Am J Epidemiol 176(11):970–978. doi:10.1093/aje/kws263

    Article  PubMed  Google Scholar 

  25. Chen C, Xu T, Chen J, Zhou J, Yan Y, Lu Y, Wu S (2011) Allergy and risk of glioma: a meta-analysis. Eur J Neurol 18(3):387–395. doi:10.1111/j.1468-1331.2010.03187.x

    Article  CAS  PubMed  Google Scholar 

  26. Cheng J, Zens MS, Duell E, Perry AE, Chapman MS, Karagas MR (2015) History of allergy and atopic dermatitis in relation to squamous cell and basal cell carcinoma of the skin. Cancer Epidemiol Biomark Prev 24(4):749–754. doi:10.1158/1055-9965.epi-14-1243

    Article  CAS  Google Scholar 

  27. Cooper GS, Kamel F, Sandler DP, Davey FR, Bloomfield CD (1996) Risk of adult acute leukemia in relation to prior immune-related conditions. Cancer Epidemiol Biomark Prev 5(11):867–872

    CAS  Google Scholar 

  28. Cotterchio M, Lowcock E, Hudson TJ, Greenwood C, Gallinger S (2014) Association between allergies and risk of pancreatic cancer. Cancer Epidemiol Biomark Prev 23(3):469–480. doi:10.1158/1055-9965.epi-13-0965

    Article  CAS  Google Scholar 

  29. Cozen W, Cerhan JR, Martinez-Maza O, Ward MH, Linet M, Colt JS, Davis S, Severson RK, Hartge P, Bernstein L (2007) The effect of atopy, childhood crowding, and other immune-related factors on non-Hodgkin lymphoma risk. Cancer Causes & Control: CCC 18(8):821–831. doi:10.1007/s10552-007-9025-5

    Article  CAS  PubMed  Google Scholar 

  30. Denholm R, Schuz J, Straif K, Stucker I, Jockel KH, Brenner DR, De Matteis S, Boffetta P, Guida F, Bruske I, Wichmann HE, Landi MT, Caporaso N, Siemiatycki J, Ahrens W, Pohlabeln H, Zaridze D, Field JK, McLaughlin J, Demers P, Szeszenia-Dabrowska N, Lissowska J, Rudnai P, Fabianova E, Dumitru RS, Bencko V, Foretova L, Janout V, Kendzia B, Peters S, Behrens T, Vermeulen R, Bruning T, Kromhout H, C Olsson A (2014) Is previous respiratory disease a risk factor for lung cancer? Am J Respir Crit Care Med 190(5):549–559. doi:10.1164/rccm.201402-0338OC

    Article  PubMed  PubMed Central  Google Scholar 

  31. Dikalioti SK, Chang ET, Dessypris N, Papadopoulou C, Skenderis N, Pourtsidis A, Moschovi M, Polychronopoulou S, Athanasiadou-Piperopoulou F, Sidi V, Kalmanti M, Petridou ET (2012) Allergy-associated symptoms in relation to childhood non-Hodgkin’s as contrasted to Hodgkin’s lymphomas: a case-control study in Greece and meta-analysis. Eur J Cancer (Oxford, England: 1990) 48(12):1860–1866. doi:10.1016/j.ejca.2011.12.010

    Article  Google Scholar 

  32. Ellison-Loschmann L, Benavente Y, Douwes J, Buendia E, Font R, Alvaro T, Kogevinas M, de Sanjose S (2007) Immunoglobulin E levels and risk of lymphoma in a case-control study in Spain. Cancer Epidemiol Biomark Prev 16(7):1492–1498. doi:10.1158/1055-9965.epi-07-0176

    Article  CAS  Google Scholar 

  33. El-Zein M, Parent ME, Siemiatycki J, Rousseau MC (2014) History of allergic diseases and lung cancer risk. Ann Allergy Asthma Immunol 112(3):230–236. doi:10.1016/j.anai.2013.12.021

    Article  PubMed  Google Scholar 

  34. Engkilde K, Thyssen JP, Menne T, Johansen JD (2011) Association between cancer and contact allergy: a linkage study. BMJ Open 1(1):e000084. doi:10.1136/bmjopen-2011-000084

    Article  PubMed  PubMed Central  Google Scholar 

  35. Eppel A, Cotterchio M, Gallinger S (2007) Allergies are associated with reduced pancreas cancer risk: a population-based case-control study in Ontario, Canada. Int J Cancer 121(10):2241–2245. doi:10.1002/ijc.22884

    Article  CAS  PubMed  Google Scholar 

  36. Eriksson NE, Holmen A, Hogstedt B, Mikoczy Z, Hagmar L (1995) A prospective study of cancer incidence in a cohort examined for allergy. Allergy 50(9):718–722

    Article  CAS  PubMed  Google Scholar 

  37. Fabbro-Peray P, Daures JP, Rossi JF (2001) Environmental risk factors for non-Hodgkin’s lymphoma: a population-based case-control study in Languedoc-Roussillon, France. Cancer Causes & Control: CCC 12(3):201–212

    Article  CAS  PubMed  Google Scholar 

  38. Gandini S, Lowenfels AB, Jaffee EM, Armstrong TD, Maisonneuve P (2005) Allergies and the risk of pancreatic cancer: a meta-analysis with review of epidemiology and biological mechanisms. Cancer Epidemiol Biomark Prev 14(8):1908–1916. doi:10.1158/1055-9965.EPI-05-0119

    Article  Google Scholar 

  39. Gomez-Rubio P, Zock JP, Rava M, Marquez M, Sharp L, Hidalgo M, Carrato A, Ilzarbe L, Michalski C, Molero X, Farre A, Perea J, Greenhalf W, O'Rorke M, Tardon A, Gress T, Barbera V, Crnogorac-Jurcevic T, Dominguez-Munoz E, Munoz-Bellvis L, Alvarez-Urturi C, Balcells J, Barneo L, Costello E, Guillen-Ponce C, Kleeff J, Kong B, Lawlor R, Lohr M, Mora J, Murray L, O'Driscoll D, Pelaez P, Poves I, Scarpa A, Real FX, Malats N (2015) Reduced risk of pancreatic cancer associated with asthma and nasal allergies. Gut. doi:10.1136/gutjnl-2015-310442

    PubMed  Google Scholar 

  40. Gonzalez-Perez A, Fernandez-Vidaurre C, Rueda A, Rivero E, Garcia Rodriguez LA (2006) Cancer incidence in a general population of asthma patients. Pharmacoepidemiol Drug Saf 15(2):131–138. doi:10.1002/pds.1163

    Article  PubMed  Google Scholar 

  41. Grulich AE, Vajdic CM, Kaldor JM, Hughes AM, Kricker A, Fritschi L, Turner JJ, Milliken S, Benke G, Armstrong BK (2005) Birth order, atopy, and risk of non-Hodgkin lymphoma. J Natl Cancer Inst 97(8):587–594. doi:10.1093/jnci/dji098

    Article  PubMed  Google Scholar 

  42. Hedderson MM, Malone KE, Daling JR, White E (2003) Allergy and risk of breast cancer among young women (United States). Cancer Causes & Control: CCC 14(7):619–626

    Article  PubMed  Google Scholar 

  43. Helby J, Bojesen SE, Nielsen SF, Nordestgaard BG (2015) IgE and risk of cancer in 37 747 individuals from the general population. Ann Oncol 26(8):1784–1790. doi:10.1093/annonc/mdv231

    Article  CAS  PubMed  Google Scholar 

  44. Holly EA, Eberle CA, Bracci PM (2003) Prior history of allergies and pancreatic cancer in the San Francisco Bay area. Am J Epidemiol 158(5):432–441

    Article  PubMed  Google Scholar 

  45. Holly EA, Lele C, Bracci PM, McGrath MS (1999) Case-control study of non-Hodgkin’s lymphoma among women and heterosexual men in the San Francisco Bay Area, California. Am J Epidemiol 150(4):375–389

    Article  CAS  PubMed  Google Scholar 

  46. Hsiao JR, Ou CY, Lo HI, Huang CC, Lee WT, Huang JS, Chen KC, Wong TY, Tsai ST, Yen CJ, Wu YH, Hsueh WT, Yang MW, Wu SY, Chang JY, Chang KY, Lin CL, Wang FT, Wang YH, Weng YL, Yang HC, Chang JS (2013) Allergies and risk of head and neck cancer: an original study plus meta-analysis. PLoS One 8(2):e55138. doi:10.1371/journal.pone.0055138

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Hughes AM, Lightfoot T, Simpson J, Ansell P, McKinney PA, Kinsey SE, Mitchell CD, Eden TO, Greaves M, Roman E (2007) Allergy and risk of childhood leukaemia: results from the UKCCS. Int J Cancer 121(4):819–824. doi:10.1002/ijc.22702

    Article  CAS  PubMed  Google Scholar 

  48. Hwang CY, Chen YJ, Lin MW, Chen TJ, Chu SY, Chen CC, Lee DD, Chang YT, Wang WJ, Liu HN (2012) Cancer risk in patients with allergic rhinitis, asthma and atopic dermatitis: a nationwide cohort study in Taiwan. Int J Cancer 130(5):1160–1167. doi:10.1002/ijc.26105

    Article  CAS  PubMed  Google Scholar 

  49. Il'yasova D, McCarthy B, Marcello J, Schildkraut JM, Moorman PG, Krishnamachari B, Ali-Osman F, Bigner DD, Davis F (2009) Association between glioma and history of allergies, asthma, and eczema: a case-control study with three groups of controls. Cancer Epidemiol Biomark Prev 18(4):1232–1238. doi:10.1158/1055-9965.epi-08-0995

    Article  Google Scholar 

  50. Jacobs EJ, Gapstur SM, Newton CC, Turner MC, Campbell PT (2013) Hay fever and asthma as markers of atopic immune response and risk of colorectal cancer in three large cohort studies. Cancer Epidemiol Biomark Prev 22(4):661–669. doi:10.1158/1055-9965.epi-12-1229

    Article  CAS  Google Scholar 

  51. Jensen AO, Svaerke C, Kormendine Farkas D, Olesen AB, Kragballe K, Sorensen HT (2012) Atopic dermatitis and risk of skin cancer: a Danish nationwide cohort study (1977–2006). Am J Clin Dermatol 13(1):29–36. doi:10.2165/11593280-000000000-00000

    Article  PubMed  Google Scholar 

  52. Ji J, Shu X, Li X, Sundquist K, Sundquist J, Hemminki K (2009) Cancer risk in hospitalised asthma patients. Br J Cancer 100(5):829–833. doi:10.1038/sj.bjc.6604890

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Johnson LG, Schwartz SM, Malkki M, Du Q, Petersdorf EW, Galloway DA, Madeleine MM (2011) Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster. Cancer Epidemiol Biomark Prev 20(1):199–207. doi:10.1158/1055-9965.EPI-10-0779

    Article  CAS  Google Scholar 

  54. Knittelfelder R, Riemer AB, Jensen-Jarolim E (2009) Mimotope vaccination—from allergy to cancer. Expert Opin Biol Ther 9(4):493–506. doi:10.1517/14712590902870386

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Lariou MS, Dikalioti SK, Dessypris N, Baka M, Polychronopoulou S, Athanasiadou-Piperopoulou F, Kalmanti M, Fragandrea I, Moschovi M, Germenis AE, Petridou ET (2013) Allergy and risk of acute lymphoblastic leukemia among children: a nationwide case control study in Greece. Cancer Epidemiol 37(2):146–151. doi:10.1016/j.canep.2012.10.012

    Article  PubMed  Google Scholar 

  56. Lowcock EC, Cotterchio M, Ahmad N (2013) Association between allergies, asthma, and breast cancer risk among women in Ontario, Canada. Cancer Causes & Control: CCC 24(5):1053–1056. doi:10.1007/s10552-013-0177-1

    Article  PubMed  Google Scholar 

  57. Melbye M, Smedby KE, Lehtinen T, Rostgaard K, Glimelius B, Munksgaard L, Schollkopf C, Sundstrom C, Chang ET, Koskela P, Adami HO, Hjalgrim H (2007) Atopy and risk of non-Hodgkin lymphoma. J Natl Cancer Inst 99(2):158–166. doi:10.1093/jnci/djk019

    Article  PubMed  Google Scholar 

  58. Michaud DS, Langevin SM, Eliot M, Nelson HH, McClean MD, Christensen BC, Marsit CJ, Kelsey KT (2012) Allergies and risk of head and neck cancer. Cancer Causes & Control: CCC 23(8):1317–1322. doi:10.1007/s10552-012-0009-8

    Article  PubMed  PubMed Central  Google Scholar 

  59. Michils A, Yernault J, Chaarani BE (1995) Lung cancer-related changing profile of B-cell epitopes recognized on mucosal antigens: the Der p1 model. Cancer 76(7):1166–1175

    Article  CAS  PubMed  Google Scholar 

  60. Negri E, Bosetti C, La Vecchia C, Levi F, Tomei F, Franceschi S (1999) Allergy and other selected diseases and risk of colorectal cancer. Eur J Cancer (Oxford, England: 1990) 35(13):1838–1841

    Article  CAS  Google Scholar 

  61. Olson SH, Hsu M, Wiemels JL, Bracci PM, Zhou M, Patoka J, Reisacher WR, Wang J, Kurtz RC, Silverman DT, Stolzenberg-Solomon RZ (2014) Serum immunoglobulin e and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. Cancer Epidemiol Biomark Prev 23(7):1414–1420. doi:10.1158/1055-9965.epi-13-1359

    Article  CAS  Google Scholar 

  62. Olson SH, Orlow I, Simon J, Tommasi D, Roy P, Bayuga S, Ludwig E, Zauber AG, Kurtz RC (2007) Allergies, variants in IL-4 and IL-4R alpha genes, and risk of pancreatic cancer. Cancer Detect Prev 31(5):345–351. doi:10.1016/j.cdp.2007.10.002

    Article  CAS  PubMed  Google Scholar 

  63. Osann KE, Lowery JT, Schell MJ (2000) Small cell lung cancer in women: risk associated with smoking, prior respiratory disease, and occupation. Lung Cancer 28(1):1–10

    Article  CAS  PubMed  Google Scholar 

  64. Petridou E, Trichopoulos D, Kalapothaki V, Pourtsidis A, Kogevinas M, Kalmanti M, Koliouskas D, Kosmidis H, Panagiotou JP, Piperopoulou F, Tzortzatou F (1997) The risk profile of childhood leukaemia in Greece: a nationwide case-control study. Br J Cancer 76(9):1241–1247

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  65. Petridou ET, Chavelas C, Dikalioti SK, Dessypris N (2007) Breast cancer risk in relation to most prevalent IgE specific antibodies. Anticancer Research

  66. Prizment AE, Folsom AR, Cerhan JR, Flood A, Ross JA, Anderson KE (2007) History of allergy and reduced incidence of colorectal cancer, Iowa Women’s Health Study. Cancer Epidemiol Biomark Prev 16(11):2357–2362. doi:10.1158/1055-9965.epi-07-0468

    Article  Google Scholar 

  67. Rosenbaum PF, Buck GM, Brecher ML (2005) Allergy and infectious disease histories and the risk of childhood acute lymphoblastic leukaemia. Paediatr Perinat Epidemiol 19(2):152–164. doi:10.1111/j.1365-3016.2005.00634.x

    Article  PubMed  Google Scholar 

  68. Rudant J, Orsi L, Menegaux F, Petit A, Baruchel A, Bertrand Y, Lambilliotte A, Robert A, Michel G, Margueritte G, Tandonnet J, Mechinaud F, Bordigoni P, Hemon D, Clavel J (2010) Childhood acute leukemia, early common infections, and allergy: the ESCALE study. Am J Epidemiol 172(9):1015–1027. doi:10.1093/aje/kwq233

    Article  PubMed  Google Scholar 

  69. Rudant J, Orsi L, Monnereau A, Patte C, Pacquement H, Landman-Parker J, Bergeron C, Robert A, Michel G, Lambilliotte A, Aladjidi N, Gandemer V, Lutz P, Margueritte G, Plantaz D, Mechinaud F, Hemon D, Clavel J (2011) Childhood Hodgkin’s lymphoma, non-Hodgkin’s lymphoma and factors related to the immune system: the Escale Study (SFCE). Int J Cancer 129(9):2236–2247. doi:10.1002/ijc.25862

    Article  CAS  PubMed  Google Scholar 

  70. Scala E, Abeni D, Palazzo P, Liso M, Pomponi D, Lombardo G, Picchio MC, Narducci MG, Russo G, Mari A (2012) Specific IgE toward allergenic molecules is a new prognostic marker in patients with Sezary syndrome. Int Arch Allergy Immunol 157(2):159–167. doi:10.1159/000327553

    Article  CAS  PubMed  Google Scholar 

  71. Schoemaker MJ, Swerdlow AJ, Hepworth SJ, McKinney PA, van Tongeren M, Muir KR (2006) History of allergies and risk of glioma in adults. Int J Cancer 119(9):2165–2172. doi:10.1002/ijc.22091

    Article  CAS  PubMed  Google Scholar 

  72. Schuz J, Morgan G, Bohler E, Kaatsch P, Michaelis J (2003) Atopic disease and childhood acute lymphoblastic leukemia. Int J Cancer 105(2):255–260. doi:10.1002/ijc.11054

    Article  CAS  PubMed  Google Scholar 

  73. Schwartzbaum J, Ding B, Johannesen TB, Osnes LT, Karavodin L, Ahlbom A, Feychting M, Grimsrud TK (2012) Association between prediagnostic IgE levels and risk of glioma. J Natl Cancer Inst 104(16):1251–1259. doi:10.1093/jnci/djs315

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. Shu X, Prochazka M, Lannering B, Schuz J, Roosli M, Tynes T, Kuehni CE, Andersen TV, Infanger D, Schmidt LS, Poulsen AH, Klaeboe L, Eggen T, Feychting M (2014) Atopic conditions and brain tumor risk in children and adolescents—an international case-control study (CEFALO). Ann Oncol 25(4):902–908. doi:10.1093/annonc/mdu048

    Article  CAS  PubMed  Google Scholar 

  75. Silverman DT, Schiffman M, Everhart J, Goldstein A, Lillemoe KD, Swanson GM, Schwartz AG, Brown LM, Greenberg RS, Schoenberg JB, Pottern LM, Hoover RN, Fraumeni JF Jr (1999) Diabetes mellitus, other medical conditions and familial history of cancer as risk factors for pancreatic cancer. Br J Cancer 80(11):1830–1837. doi:10.1038/sj.bjc.6690607

  76. Skaaby T, Nystrup Husemoen LL, Roswall N, Thuesen BH, Linneberg A (2014) Atopy and development of cancer: a population-based prospective study. J Allergy Clin Immunol Pract 2(6):779–785. doi:10.1016/j.jaip.2014.06.010

    Article  PubMed  Google Scholar 

  77. Smedby KE, Sampson JN, Turner JJ, Slager SL, Maynadie M, Roman E, Habermann TM, Flowers CR, Berndt SI, Bracci PM, Hjalgrim H, Weisenburger DD, Morton LM (2014) Medical history, lifestyle, family history, and occupational risk factors for mantle cell lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project. J Natl Cancer Inst Monogr 2014(48):76–86. doi:10.1093/jncimonographs/lgu007

    Article  PubMed  PubMed Central  Google Scholar 

  78. Soderberg KC, Hagmar L, Schwartzbaum J, Feychting M (2004) Allergic conditions and risk of hematological malignancies in adults: a cohort study. BMC Public Health 4:51. doi:10.1186/1471-2458-4-51

    Article  PubMed  PubMed Central  Google Scholar 

  79. Spector L, Groves F, DeStefano F, Liff J, Klein M, Mullooly J, Black S, Shinefield H, Ward J, Marcy M (2004) Medically recorded allergies and the risk of childhood acute lymphoblastic leukaemia. Eur J Cancer (Oxford, England: 1990) 40(4):579–584. doi:10.1016/j.ejca.2003.08.024

    Article  CAS  Google Scholar 

  80. Stolzenberg-Solomon RZ, Pietinen P, Taylor PR, Virtamo J, Albanes D (2002) A prospective study of medical conditions, anthropometry, physical activity, and pancreatic cancer in male smokers (Finland). Cancer Causes & Control: CCC 13(5):417–426

    Article  PubMed  Google Scholar 

  81. Su YL, Chou CL, Rau KM, Lee CT (2015) Asthma and risk of prostate cancer: a population-based case-cohort study in Taiwan. Medicine (Baltimore) 94(36):e1371. doi:10.1097/md.0000000000001371

    Article  CAS  Google Scholar 

  82. Synnerstad I, Fredrikson M, Ternesten-Bratel A, Rosdahl I (2008) Low risk of melanoma in patients with atopic dermatitis. J Eur Acad Dermatol Venereol 22(12):1423–1428. doi:10.1111/j.1468-3083.2008.02888.x

    Article  CAS  PubMed  Google Scholar 

  83. Talbot-Smith A (2003) Allergy, atopy, and cancer: a prospective study of the 1981 Busselton cohort. Am J Epidemiol 157(7):606–612. doi:10.1093/aje/kwg020

    Article  PubMed  Google Scholar 

  84. Tambe NA, Wilkens LR, Wan P, Stram DO, Gilliland F, Park SL, Cozen W, Martinez-Maza O, Le Marchand L, Henderson BE, Haiman CA (2015) Atopic allergic conditions and colorectal cancer risk in the multiethnic cohort study. Am J Epidemiol 181(11):889–897. doi:10.1093/aje/kwu361

    Article  PubMed  PubMed Central  Google Scholar 

  85. Vajdic CM, Falster MO, de Sanjose S, Martinez-Maza O, Becker N, Bracci PM, Melbye M, Smedby KE, Engels EA, Turner J, Vineis P, Costantini AS, Holly EA, Kane E, Spinelli JJ, La Vecchia C, Zheng T, Chiu BC, Dal Maso L, Cocco P, Maynadie M, Foretova L, Staines A, Brennan P, Davis S, Severson R, Cerhan JR, Breen EC, Birmann B, Cozen W, Grulich AE (2009) Atopic disease and risk of non-Hodgkin lymphoma: an InterLymph pooled analysis. Cancer Res 69(16):6482–6489. doi:10.1158/0008-5472.can-08-4372

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Vajdic CM, Fritschi L, Grulich AE, Kaldor JM, Benke G, Kricker A, Hughes AM, Turner JJ, Milliken S, Goumas C, Armstrong BK (2007) Atopy, exposure to pesticides and risk of non-Hodgkin lymphoma. Int J Cancer 120(10):2271–2274. doi:10.1002/ijc.22602

    Article  CAS  PubMed  Google Scholar 

  87. Vineis P, Crosignani P, Sacerdote C, Fontana A, Masala G, Miligi L, Nanni O, Ramazzotti V, Rodella S, Stagnaro E, Tumino R, Vigano C, Vindigni C, Costantini AS (2000) Haematopoietic cancer and medical history: a multicentre case control study. J Epidemiol Community Health 54(6):431–436

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Vojtechova P, Martin RM (2009) The association of atopic diseases with breast, prostate, and colorectal cancers: a meta-analysis. Cancer Causes & Control: CCC 20(7):1091–1105. doi:10.1007/s10552-009-9334-y

    Article  PubMed  Google Scholar 

  89. Wang H, Rothenbacher D, Low M, Stegmaier C, Brenner H, Diepgen TL (2006) Atopic diseases, immunoglobulin E and risk of cancer of the prostate, breast, lung and colorectum. Int J Cancer 119(3):695–701. doi:10.1002/ijc.21883

    Article  PubMed  CAS  Google Scholar 

  90. Weiss D, El-Zein M, Rousseau MC, Richard H, Karakiewicz PI, Parent ME (2014) Asthma, allergy and the risk of prostate cancer: results from the Montreal PROtEuS study. Cancer Epidemiol 38(6):695–699. doi:10.1016/j.canep.2014.10.003

    Article  PubMed  Google Scholar 

  91. Wen W, Shu XO, Linet MS, Neglia JP, Potter JD, Trigg ME, Robison LL (2000) Allergic disorders and the risk of childhood acute lymphoblastic leukemia (United States). Cancer Causes & Control: CCC 11(4):303–307

    Article  CAS  PubMed  Google Scholar 

  92. Wiemels JL, Wiencke JK, Li Z, Ramos C, Nelson HH, Karagas MR (2011) Risk of squamous cell carcinoma of the skin in relation to IgE: a nested case-control study. Cancer Epidemiol Biomark Prev 20(11):2377–2383. doi:10.1158/1055-9965.epi-11-0668

    Article  CAS  Google Scholar 

  93. Wiemels JL, Wiencke JK, Sison JD, Miike R, McMillan A, Wrensch M (2002) History of allergies among adults with glioma and controls. Int J Cancer 98(4):609–615

    Article  CAS  PubMed  Google Scholar 

  94. Wiemels JL, Wiencke JP (2004) Reduced immunoglobulin E and allergy among adults with glioma compared with controls. Cancer Res 64(22):8468–8473

    Article  CAS  PubMed  Google Scholar 

  95. Wigertz A, Lonn S, Schwartzbaum J, Hall P, Auvinen A, Christensen HC, Johansen C, Klaeboe L, Salminen T, Schoemaker MJ, Swerdlow AJ, Tynes T, Feychting M (2007) Allergic conditions and brain tumor risk. Am J Epidemiol 166(8):941–950. doi:10.1093/aje/kwm203

    Article  PubMed  Google Scholar 

  96. Wu AH, Fontham ET, Reynolds P, Greenberg RS, Buffler P, Liff J, Boyd P, Henderson BE, Correa P (1995) Previous lung disease and risk of lung cancer among lifetime nonsmoking women in the United States. Am J Epidemiol 141(11):1023–1032

    Article  CAS  PubMed  Google Scholar 

  97. Annesi-Maesano I, Didier A, Klossek M, Chanal I, Moreau D, Bousquet J (2002) The score for allergic rhinitis (SFAR): a simple and valid assessment method in population studies. Allergy 57(2):107–114

    Article  CAS  PubMed  Google Scholar 

  98. Toren K, Brisman J, Jarvholm B (1993) Asthma and asthma-like symptoms in adults assessed by questionnaires. A literature review. Chest 104(2):600–608

    Article  CAS  PubMed  Google Scholar 

  99. Pedotti R, Losappio L, Farinotti M, Preziosi D, Tramacere I, Stafylaraki C, Mascheri A, Filippini G, Pastorello EA (2015) Accuracy of a questionnaire for identifying respiratory allergies in epidemiological studies. Rhinology 53(1):49–53. doi:10.4193/Rhin14.047

    PubMed  Google Scholar 

  100. Kilpelainen M, Terho EO, Helenius H, Koskenvuo M (2001) Validation of a new questionnaire on asthma, allergic rhinitis, and conjunctivitis in young adults. Allergy 56(5):377–384

    Article  CAS  PubMed  Google Scholar 

  101. Williams HC, Burney PG, Pembroke AC, Hay RJ (1996) Validation of the U.K. diagnostic criteria for atopic dermatitis in a population setting. U.K. Diagnostic Criteria for Atopic Dermatitis Working Party. Br J Dermatol 135(1):12–17

    Article  CAS  PubMed  Google Scholar 

  102. Maddox L, Schwartz DA (2002) The pathophysiology of asthma. Annu Rev Med 53:477–498. doi:10.1146/annurev.med.53.082901.103921

    Article  CAS  PubMed  Google Scholar 

  103. Honkoop PJ, Loijmans RJ, Termeer EH, Snoeck-Stroband JB, Ter Riet G, Schermer TR, Sont JK (2013) Comparison between an online self-administered and an interviewer-administered version of the Asthma Control Questionnaire: a cross-sectional validation study. Prim Care Respir J 22(3):284–289. doi:10.4104/pcrj.2013.00041

    Article  PubMed  Google Scholar 

  104. Pless CE, Pless IB (1995) How well they remember. The accuracy of parent reports. Arch Pediatr Adolesc Med 149(5):553–558

    Article  CAS  PubMed  Google Scholar 

  105. Kurtz ME, Kurtz JC, Given CC, Given B (1996) Concordance of cancer patient and caregiver symptom reports. Cancer Pract 4(4):185–190

    CAS  PubMed  Google Scholar 

  106. Bagnardi V, Rota M, Botteri E, Tramacere I, Islami F, Fedirko V, Scotti L, Jenab M, Turati F, Pasquali E, Pelucchi C, Galeone C, Bellocco R, Negri E, Corrao G, Boffetta P, La Vecchia C (2015) Alcohol consumption and site-specific cancer risk: a comprehensive dose-response meta-analysis. Br J Cancer 112(3):580–593. doi:10.1038/bjc.2014.579

    Article  CAS  PubMed  Google Scholar 

  107. Gonzalez-Quintela A, Gude F, Boquete O, Rey J, Meijide LM, Suarez F, Fernandez-Merino MC, Perez LF, Vidal C (2003) Association of alcohol consumption with total serum immunoglobulin E levels and allergic sensitization in an adult population-based survey. Clin Exp Allergy 33(2):199–205

    Article  CAS  PubMed  Google Scholar 

  108. Linneberg A, Petersen J, Nielsen NH, Madsen F, Frolund L, Dirksen A, Jorgensen T (2003) The relationship of alcohol consumption to total immunoglobulin E and the development of immunoglobulin E sensitization: the Copenhagen Allergy Study. Clin Exp Allergy 33(2):192–198

    Article  CAS  PubMed  Google Scholar 

  109. Park S, Kim Y, Shin HR, Lee B, Shin A, Jung KW, Jee SH, Kim DH, Yun YH, Park SK, Boniol M, Boffetta P (2014) Population-attributable causes of cancer in Korea: obesity and physical inactivity. PLoS One 9(4):e90871. doi:10.1371/journal.pone.0090871

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  110. Toskala E, Kennedy DW (2015) Asthma risk factors. Int Forum Allergy Rhinol 5(Suppl 1):S11–S16. doi:10.1002/alr.21557

    Article  PubMed  Google Scholar 

  111. Bergmann RL, Edenharter G, Bergmann KE, Lau S, Wahn U (2000) Socioeconomic status is a risk factor for allergy in parents but not in their children. Clin Exp Allergy 30(12):1740–1745

    Article  CAS  PubMed  Google Scholar 

  112. Boyd C, Zhang-Salomons JY, Groome PA, Mackillop WJ (1999) Associations between community income and cancer survival in Ontario, Canada, and the United States. J Clin Oncol 17(7):2244–2255

    Article  CAS  PubMed  Google Scholar 

  113. Lewis SA, Weiss ST, Platts-Mills TA, Syring M, Gold DR (2001) Association of specific allergen sensitization with socioeconomic factors and allergic disease in a population of Boston women. J Allergy Clin Immunol 107(4):615–622. doi:10.1067/mai.2001.113523

    Article  CAS  PubMed  Google Scholar 

  114. Matricardi PM, Franzinelli F, Franco A, Caprio G, Murru F, Cioffi D, Ferrigno L, Palermo A, Ciccarelli N, Rosmini F (1998) Sibship size, birth order, and atopy in 11,371 Italian young men. J Allergy Clin Immunol 101(4 Pt 1):439–444

    Article  CAS  PubMed  Google Scholar 

  115. Williams HC, Strachan DP, Hay RJ (1994) Childhood eczema: disease of the advantaged? BMJ 308(6937):1132–1135

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Acknowledgments

This work was supported by the National Sciences Foundation of China (NSFC 30060166, NSFC81001330, NSFC31272369, NSFC31572319).

Author information

Authors and Affiliations

  1. Department of Clinical Laboratory, The Third People’s Hospital of Yancheng, Affiliated Yancheng Hospital, School of Medicine, Southeast University, No. 299 at Jiefangnan Road, Yancheng, 224000, Jiangsu Province, China

    Yubao Cui

  2. Department of Epidemiology and Biostatistics, School of Public Health and Health Services, The George Washington University, Washington, DC, 20052, USA

    Andrew W. Hill

Authors
  1. Yubao Cui
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Andrew W. Hill
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Yubao Cui.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Cui, Y., Hill, A.W. Atopy and Specific Cancer Sites: a Review of Epidemiological Studies. Clinic Rev Allerg Immunol 51, 338–352 (2016). https://doi.org/10.1007/s12016-016-8559-2

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12016-016-8559-2

Keywords

Search

Navigation