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Cardioprotection by Phytochemicals via Antiplatelet Effects and Metabolism Modulations

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Abstract

The multi-factorial aetiology is the characteristic element of cardiac disorders. Further scientific research had recognized for a long time that platelet function is related to the risk of developing atherosclerosis. Activated blood platelets play a central role in this chronic inflammatory condition as they contribute to plaque formation within blood vessels in the early stages of atherogenesis. The present review article summarizes the cardioprotective role played by Phytochemicals via antiplatelet effects. Also, various metabolic modifications have been included that have protective effect during cardiac pathology.

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References

  1. Shahidi, F., & Naczk, M. (1995). Food phenolics: Sources, chemistry, effects, applications. Lancaster, PA: Technomic Publishing Co. Inc.

    Google Scholar 

  2. Manach, C., Scalbert, A., Morand, C., Remesy, C., & Jimenez, L. (2004). Polyphenols: food sources and bioavailability. American Journal of Clinical Nutrition, 79, 727–747.

    CAS  PubMed  Google Scholar 

  3. Carotenuto, A., Fattorusso, E., Lanzotti, V., Magno, S., De Feo, V., & Cicala, C. (1997). The flavonoids of Allium neapolitanum. Phytochemistry, 44, 949–957.

    Article  CAS  PubMed  Google Scholar 

  4. Bravo, L. (1998). Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance. Nutrition Reviews, 56, 317–333.

    Article  CAS  PubMed  Google Scholar 

  5. Lin, J. H., Chiou, Y. N., & Lin, Y. L. (2002). Phenolic glycosides from Viscum angulatum. Journal of Natural Products, 65, 638–640.

    Article  CAS  PubMed  Google Scholar 

  6. Butterfield, D., Castegna, A., Pocernich, C., Drake, J., Scapagnini, G., & Calabrese, V. (2002). Nutritional approaches to combat oxidative stress in Alzheimer’s disease. Journal of Nutritional Biochemistry, 13, 444.

    Article  CAS  PubMed  Google Scholar 

  7. Santos-Buelga, C., & Scalbert, A. (2000). Proanthocyanidins and tannin-like compounds—Nature, occurrence, dietary intake and effects on nutrition and health. Journal of the Science of Food and Agriculture, 80, 1094–1117.

    Article  CAS  Google Scholar 

  8. Herrmann, K. (1989). Occurrence and content of hydroxycinnamic and hydroxybenzoic acid compounds in foods. Critical Reviews in Food Science and Nutrition, 28, 315–347.

    Article  CAS  PubMed  Google Scholar 

  9. Scalbert, A., & Williamson, G. (2000). Dietary intake and bioavailability of polyphenols. Journal of Nutrition, 130, 2073s–2085s.

    CAS  PubMed  Google Scholar 

  10. Schuster, B., & Herrmann, K. (1985). Hydroxybenzoic and hydroxycinnamic acid derivatives in soft fruits. Phytochemistry, 24, 2761–2764.

    Article  CAS  Google Scholar 

  11. Winter, M., & Herrmann, K. (1986). Esters and glucosides of hydroxycinnamic acids in vegetables. Journal of Agriculture and Food Chemistry, 34, 616–620.

    Article  CAS  Google Scholar 

  12. Klick, S., & Herrmann, K. (1988). Glycosides and glucose esters of hydroxybenzoic acids in plants. Phytochemistry, 27, 2177–2180.

    Article  CAS  Google Scholar 

  13. Robbins, R. J. (2003). Phenolic acids in foods: An overview of analytical methodology. Journal of Agriculture and Food Chemistry, 2003(51), 2866–2887.

    Article  Google Scholar 

  14. Shahidi, F., & Naczk, M. (2003). Phenolics in food and neutraceuticals. Boca Raton, FL: CRC Press.

    Google Scholar 

  15. Harborne, J. B., & Williams, C. A. (2000). Advances in flavonoid research since 1992. Phytochemistry, 2000(55), 481–504.

    Article  Google Scholar 

  16. Nichenametla, S. N., Taruscio, T. G., Barney, D. L., & Exon, J. H. (2006). A review of the effects and mechanisms of polyphenolics in cancer. Critical Reviews in Food Science and Nutrition, 46, 161–183.

    Article  CAS  PubMed  Google Scholar 

  17. Williams, C. A., & Grayer, R. J. (2004). Anthocyanins and other flavonoids. Natural Products Reports, 2004(21), 539–573.

    Article  Google Scholar 

  18. Grayer, R. J., & Veitch, N. C. (2005). Flavanones and dihydroflavanols. In O. M. Andersen & K. R. Markham (Eds.), Flavonoids: Chemistry, biochemistry and applications (pp. 917–1002). Boca Raton: CRC Press.

    Chapter  Google Scholar 

  19. Lee, M. H., Kim, J. Y., & Ryu, J. H. (2005). Prenylflavones from Psoralea corylifolia inhibit nitric oxide synthase expression through the inhibition of I-kappaB-alpha degradation in activated microglial cells. Biological &/and Pharmaceutical Bulletin, 28, 2253–2257.

    Article  CAS  Google Scholar 

  20. Price, S. F., Breen, P. J., Valladao, M., & Waston, B. T. (1995). Cluster sun exposure and quercetin in Pinot noir grapes and wine. American Journal of Enology and Viticulture, 46, 187–194.

    CAS  Google Scholar 

  21. Coward, L., Smith, M., Kirk, M., & Barnes, S. (1998). Chemical modification of isoflavones in soyfoods during cooking and processing. American Journal of Clinical Nutrition, 68, 1486s–1491s.

    CAS  PubMed  Google Scholar 

  22. Mazza, G., & Miniani, E. (1993). Anthocyanins in fruits, vegetables and grains. London: CRC Press.

    Google Scholar 

  23. Springob, K., Nakajima, J., Yamazaki, M., & Saito, K. (2003). Recent advances in the biosynthesis and accumulation of anthocyanins. Natural Products Reports, 20, 288–303.

    Article  CAS  Google Scholar 

  24. Brouillard, R. (1982). Chemical structures of anthocyanins. In P. Markakis (Ed.), Anthocyanins as food colors. USA: Academic Press, NY.

    Google Scholar 

  25. Harborne, J. B. (1967). Comparitive biochemistry of the flavonoids. New York, NY: Academic Press.

    Google Scholar 

  26. Ferreira, D., Slade, D., & Marais, J. P. J. (2006). Flavans and proanthocyanidins. In O. M. Andersen & K. R. Markham (Eds.), Flavonoids: chemistry, biochemistry and applications. Boca Raton, FL: CRC Press.

    Google Scholar 

  27. Ferreira, E. O., Salvador, M. J., Pral, E. M., Alfieri, S. C., Ito, I. Y., & Dias, D. A. (2004). A new heptasubstituted (E)-aurone glucoside and other aromatic compounds of Gomphrena agrestis with biological activity. Zeitschrift für Naturforschung C, 59, 499–505.

    CAS  Google Scholar 

  28. Chung, K. T., Wong, T. Y., Wei, C. I., Huang, Y. W., & Lin, Y. (1998). Tannins and human health: A review. Critical Reviews in Food Science and Nutrition, 38, 421–464.

    Article  CAS  PubMed  Google Scholar 

  29. Borriello, S. P., Setchell, K. D., Axelson, M., & Lawson, A. M. (1985). Production and metabolism of lignans by the human faecal flora. Journal of Applied Bacteriology, 58, 37–43.

    Article  CAS  PubMed  Google Scholar 

  30. Meagher, L. P., Beecher, G. R., Flanagan, V. P., & Li, B. W. (1999). Isolation and characterization of the lignans, isolariciresinol and pinoresinol, in flaxseed meal. Journal of Agriculture and Food Chemistry, 47, 3173–3180.

    Article  CAS  Google Scholar 

  31. Heinonen, S., Nurmi, T., Liukkonen, K., Poutanen, K., Wahala, K., Deyama, T., et al. (2001). In vitro metabolism of plant lignans: New precursors of mammalian lignans enterolactone and enterodiol. Journal of Agriculture and Food Chemistry, 49, 3178–3186.

    Article  CAS  Google Scholar 

  32. Makkar, H. P. S. (1989). Protein precipitation methods for quantification of tannins: A review. Journal of Agriculture and Food Chemistry, 1989(37), 1197–1202.

    Article  Google Scholar 

  33. Wollgast, J., & Anklam, E. (2000). Review of polyphenols in Theobroma Cacao, changes in composition during the manufacture of chocolate and methodology for identification and quantification. Food Research International, 33, 423–447.

    Article  CAS  Google Scholar 

  34. Salunkne, D. K., Bolin, H. R., & Reddy, N. R. (1989). Storage, processing and nutritional quality of fruits and vegetables. Boca Raton, FL: CRC Press.

    Google Scholar 

  35. Dewick, P. M. (2009). Medicinal natural products: a biosynthetic approach (3rd ed.). Hoboken, NJ: Wiley.

    Book  Google Scholar 

  36. Mueller-Harvey, I. (2001). Analysis of hyrdolysable tannins. Animal Feed Science and Technology, 91, 3–20.

    Article  CAS  Google Scholar 

  37. Gu, L., Kelm, M. A., Hammerstone, J. F., Beecher, G., Holden, J., Haytowitz, D., & Prior, R. L. (2003). Screening of foods containing proanthocyanidins and their structural characterization using LC–MS/MS and thiolytic degradation. Journal of Agriculture and Food Chemistry, 51, 7513–7521.

    Article  CAS  Google Scholar 

  38. Gu, L., Kelm, M. A., Hammerstone, J. F., Beecher, G., Holden, J., Haytowitz, D., & Prior, R. L. (2004). Concentrations of proanthocyanidins in common foods and estimations of normal consumption. Journal of Nutrition, 134, 613–617.

    CAS  PubMed  Google Scholar 

  39. U.S. Department of Agriculture Beltsville. (2003). USDA database for the flavonoid content of selected foods. Maryland: U.S. Department of Agriculture Beltsville.

    Google Scholar 

  40. Monagas, M., Gomez-Cordoves, C., Bartolome, B., Laureano, O., & Ricardo da Silva, J. M. (2003). Monomeric, oligomeric, and polymeric flavan-3-ol composition of wines and grapes from Vitis vinifera L. Cv. Graciano, Tempranillo, and Cabernet Sauvignon. Journal of Agriculture and Food Chemistry, 51, 6475–6481.

    Article  CAS  Google Scholar 

  41. Guyot, S., Marnet, N., & Drilleau, J. (2001). Thiolysis-HPLC characterization of apple procyanidins covering a large range of polymerization states. Journal of Agriculture and Food Chemistry, 49, 14–20.

    Article  CAS  Google Scholar 

  42. Clifford, M. N. (2000). Chlorogenic acids and other cinnamates. Nature, occurence, dietary burden, absorption and metabolism. Journal of the Science of Food and Agriculture, 80, 1033–1043.

    Article  CAS  Google Scholar 

  43. Scalbert, A., Manach, C., Morand, C., Remesy, C., & Jimenez, L. (2005). Dietary polyphenols and the prevention of diseases. Critical Reviews in Food Science and Nutrition, 45, 287–306.

    Article  CAS  PubMed  Google Scholar 

  44. Luqman, S., & Rizvi, S. I. (2006). Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress. Phytother Res., 20, 303–306.

    Article  CAS  PubMed  Google Scholar 

  45. Pandey, K. B., Mishra, N., & Rizvi, S. I. (2009). Protective role of myricetin on markers of oxidative stress in human erythrocytes subjected to oxidative stress. Natural Products Communications, 4, 221–226.

    CAS  Google Scholar 

  46. Pandey, K. B., & Rizvi, S. I. (2010). Protective effect of resveratrol on markers of oxidative stress in human erythrocytes subjected to in vitro oxidative insult. Phytotherapy Research, 24(Suppl 1), S11–S14.

    Article  PubMed  Google Scholar 

  47. Lambert, J. D., Hong, J., Yang, G. Y., Liao, J., & Yang, C. S. (2005). Inhibition of carcinogenesis by polyphenols: Evidence from laboratory investigations. American Journal of Clinical Nutrition, 81, 284s–291s.

    CAS  PubMed  Google Scholar 

  48. Goldschmidt, P. J., Lopes, N., Crawford, L. E., & Becker, R. C. (2007). Atherothrombosis and coronary artery disease. In A. D. Michelson (Ed.), Platelets (pp. 629–655). San Diego: Academic Press/Elsevier Inc.

    Chapter  Google Scholar 

  49. Ruggeri, Z. M. (2002). Platelets in atherothrombosis. Nature Medicine, 2002(8), 1227–1234.

    Article  Google Scholar 

  50. Davi, G., & Patrono, C. (2007). Platelet activation and atherothrombosis. New England Journal of Medicine, 357, 2482–2494.

    Article  CAS  PubMed  Google Scholar 

  51. Demrow, H. S., Slane, P. R., & Folts, J. D. (1995). Administration of wine and grape juice inhibits in vivo platelet activity and thrombosis in stenosed canine coronary arteries. Circulation, 91, 1182–1188.

    Article  CAS  PubMed  Google Scholar 

  52. Osman, H. E., Maalej, N., Shanmuganayagam, D., & Folts, J. D. (1998). Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkeys. Journal of Nutrition, 128, 2307–2312.

    CAS  PubMed  Google Scholar 

  53. Wollny, T., Aiello, L., Di Tommaso, D., Bellavia, V., Rotilio, D., Donati, M. B., et al. (1999). Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats: A role for increased nitric oxide production. British Journal of Pharmacology, 127, 747–755.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  54. Freedman, J. E., Parker, C, 3rd, Li, L., Perlman, J. A., Frei, B., Ivanov, V., et al. (2001). Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation, 103, 2792–2798.

    Article  CAS  PubMed  Google Scholar 

  55. Pignatelli, P., Pulcinelli, F. M., Celestini, A., Lenti, L., Ghiselli, A., Gazzaniga, P. P., & Violi, V. (2000). The flavonoids quercetin and catechin synergistically inhibit platelet function by antagonizing the intracellular production of hydrogen peroxide. American Journal of Clinical Nutrition, 72, 1150–1155.

    CAS  PubMed  Google Scholar 

  56. Loest, H. B., Noh, S. K., & Koo, S. I. (2002). Green tea extract inhibits the lymphatic absorption of cholesterol and alpha-tocopherol in ovariectomized rats. Journal of Nutrition, 132, 1282–1288.

    CAS  PubMed  Google Scholar 

  57. Leslie, E. M., Mao, Q., Oleschuk, C. J., Deeley, R. G., & Cole, S. P. (2001). Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. Molecular Pharmacology, 59, 1171–1180.

    CAS  PubMed  Google Scholar 

  58. Conseil, G., Baubichon-Cortay, H., Dayan, G., Jault, J. M., Barron, D., & di Pietro, A. (1998). Flavonoids: a class of modulators with bifunctional interactions at vicinal ATP- and steroid-binding sites on mouse p-glycoprotein. Proceedings of the National Academy of Sciences of the United States of America, 95, 9831–9836.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  59. Pal, S., Ho, S. S., & Takechi, R. (2005). Red wine polyphenolics suppress the secretion of ApoB48 from human intestinal CaCo-2 cells. Journal of Agriculture and Food Chemistry, 53, 2767–2772.

    Article  CAS  Google Scholar 

  60. Borradaile, N. M., de Dreu, L. E., Barrett, P. H., Behrsin, C. D., & Huff, M. W. (2003). Hepatocyte apoB-containing lipoprotein secretion is decreased by the grapefruit flavonoid, naringenin, via inhibition of MTP-mediated microsomal triglyceride accumulation. Biochemistry, 42, 1283–1291.

    Article  CAS  PubMed  Google Scholar 

  61. Borradaile, N. M., de Dreu, L. E., Barrett, P. H., & Huff, M. W. (2002). Inhibition of hepatocyte apoB secretion by naringenin: Enhanced rapid intracellular degradation independent of reduced microsomal cholesteryl esters. Journal of Lipid Research, 43, 1544–1554.

    Article  CAS  PubMed  Google Scholar 

  62. Debry, P., Nash, E. A., Neklason, D. W., & Metherall, J. E. (1997). Role of multidrug resistance p-glycoproteins in cholesterol esterification. Journal of Biological Chemistry, 272, 1026–1031.

    Article  CAS  PubMed  Google Scholar 

  63. Burnett, J. R., Wilcox, L. J., Telford, D. E., Kleinstiver, S. J., Barrett, P. H., Newton, R. S., & Huff, M. W. (1999). Inhibition of ACAT by avasimibe decreases both VLDL and LDL apolipoprotein B production in miniature pigs. Journal of Lipid Research, 40, 1317–1327.

    CAS  PubMed  Google Scholar 

  64. Auger, C., Caporiccio, B., Landrault, N., Teissedre, P. L., Laurent, C., Cros, G., et al. (2002). Red wine phenolic compounds reduce plasma lipids and apolipoprotein B and prevent early aortic atherosclerosis in hypercholesterolemic golden Syrian hamsters (Mesocricetus auratus). Journal of Nutrition, 132, 1207–1213.

    CAS  PubMed  Google Scholar 

  65. Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., et al. (2005). Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. Journal of Nutrition, 135, 1911–1917.

    CAS  PubMed  Google Scholar 

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  1. Department of Cardiology, Xuzhou Central Hospital, No. 199 South Jiefang Road, Xuzhou, 221009, Jiangsu, China

    Pei-Ying Zhang

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Zhang, PY. Cardioprotection by Phytochemicals via Antiplatelet Effects and Metabolism Modulations. Cell Biochem Biophys 73, 369–379 (2015). https://doi.org/10.1007/s12013-015-0612-x

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