Skip to main content

Advertisement

SpringerLink
Log in

Recent Advances in Epilepsy Management

  • Review Paper
  • Published:
Cell Biochemistry and Biophysics Aims and scope Submit manuscript

Abstract

One of the most common neurological disorders is epilepsy, which, approximately affecting more than 40 million people worldwide. The situation worsens in the affected patient when the epilepsy becomes intractable, that simply means failure of anti-epileptic drugs (AED) to achieve seizure freedom. It is also associated with an increased prevalence of mental health disorders including anxiety, depression, and suicidal thoughts. The present review is focused on the recent advances being utilized world over for the effective management of epilepsy patients. The review article discusses the efficacy and importance of recent AED drugs in use for management of epilepsy on one hand and on other hand highlights the use of modern advancements like High frequency oscillations, Network analysis, Seizure localization, Epilepsy surgery in curing intractable epilepsy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Brodie, M. J., & French, J. A. (2000). Management of epilepsy in adolescents and adults. Lancet, 356, 323–329.

    Article  CAS  PubMed  Google Scholar 

  2. Dichter, M. A., & Brodie, M. J. (1996). New antiepileptic drugs. New England Journal of Medicine, 334, 1583–1590.

    Article  CAS  PubMed  Google Scholar 

  3. Engel, J, Jr. (1996). Surgery for seizures. New England Journal of Medicine, 334, 647–652.

    Article  PubMed  Google Scholar 

  4. Leestma, J. E., Annegers, J. F., Brodie, M. J., et al. (1997). Sudden unexplained death in epilepsy: Observations from a large clinical development programme. Epilepsia, 38, 47–55.

    Article  CAS  PubMed  Google Scholar 

  5. Dua, T., de Boer, H. M., Prilipko, L. L., et al. (2006). Epilepsy care in the world: Results of an ILAE/IBE/WHO global campaign against epilepsy survey. Epilepsia, 47, 1225–1231.

    Article  PubMed  Google Scholar 

  6. Duncan, J. S. (2010). Imaging in the surgical treatment of epilepsy. Nature Reviews Neurology, 2010(6), 537–550.

    Article  Google Scholar 

  7. Jacobs, J., Staba, R., Asano, E., et al. (2012). High-frequency oscillations (HFOs) in clinical epilepsy. Progress in Neurobiology, 98, 302–315.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  8. Matsuoka, L. K. (1993). Spencer SS (1993) Seizure localization using subdural grid electrodes. Epilepsia, 34(Suppl. 6), 8.

    Google Scholar 

  9. Rosenow, F., & Luders, H. (2001). Presurgical evaluation of epilepsy. Brain, 2001(124), 1683–1700.

    Article  Google Scholar 

  10. Fisher, R. S., Webber, W. R., Lesser, R. P., et al. (1992). High-frequency EEG activity at the start of seizures. Journal of Clinical Neurophysiology, 9, 441–448.

    Article  CAS  PubMed  Google Scholar 

  11. Jirsch, J. D., Urrestarazu, E., LeVan, P., et al. (2006). High-frequency oscillations during human focal seizures. Brain, 129, 1593–1608.

    Article  CAS  PubMed  Google Scholar 

  12. Modur, P. N., Zhang, S., & Vitaz, T. W. (2011). Ictal high-frequency oscillations in neocortical epilepsy: Implications for seizure localization and surgical resection. Epilepsia, 52, 1792–1801.

    Article  PubMed Central  PubMed  Google Scholar 

  13. Zijlmans, M., Jacobs, J., Kahn, Y. U., et al. (2011). Ictal and interictal high frequency oscillations in patients with focal epilepsy. Clinical Neurophysiology, 122, 664–671.

    Article  PubMed Central  PubMed  Google Scholar 

  14. Jefferys, J. G. (2003). Models and mechanisms of experimental epilepsies. Epilepsia, 44(Suppl. 12), 44–50.

    Article  PubMed  Google Scholar 

  15. Chang, B. S., & Lowenstein, D. H. (2003). Epilepsy. New England Journal of Medicine, 349, 1257–1266.

    Article  PubMed  Google Scholar 

  16. McCormick, D. A., & Contreras, D. (2001). On the cellular and network bases of epileptic seizures. Annual Review of Physiology, 63, 815–846.

    Article  CAS  PubMed  Google Scholar 

  17. Commission on Neuroimaging of the International League Against Epilepsy. (1997). Recommendations for neuroimaging of patients with epilepsy. Epilepsia, 38, 1255–1256.

    Article  Google Scholar 

  18. Brodie, M. J., & Dichter, M. A. (1996). Antiepileptic drugs. New England Journal of Medicine, 1996(334), 168–175.

    Google Scholar 

  19. Brodie, M. J. (1999). Monostars: An aid to choosing an antiepileptic drug as monotherapy. Epilepsia, 40(suppl 6), 17–22.

    Article  Google Scholar 

  20. Berg, A. T., & Kelly, M. M. (2006). Defining intractability: Comparisons among published defi nitions. Epilepsia, 47, 431–436.

    Article  PubMed  Google Scholar 

  21. Berg, A. T. (2006). Defining intractable epilepsy. Advances in Neurology, 2006(97), 5–10.

    Google Scholar 

  22. Allen, P. J., Fish, D. R., & Smith, S. J. (1992). Very high-frequency rhythmic activity during SEEG suppression in frontal lobe epilepsy. Electroencephalography and Clinical Neurophysiology, 82, 155–159.

    Article  CAS  PubMed  Google Scholar 

  23. Blanco, J. A., Stead, M., Krieger, A., et al. (2010). Unsupervised classification of high-frequency oscillations in human neocortical epilepsy and control patients. Journal of Neurophysiology, 104, 2900–2912.

    Article  PubMed Central  PubMed  Google Scholar 

  24. Schevon, C. A., Weiss, S. A., McKhann, G, Jr, et al. (2012). Evidence of an inhibitory restraint of seizure activity in humans. Nature communications, 3, 1060.

    Article  PubMed Central  PubMed  Google Scholar 

  25. Varotto, G., Tassi, L., Franceschetti, S., et al. (2012). Epileptogenic networks of type II focal cortical dysplasia: A stereo-EEG study. Neuroimage, 61, 591–598.

    Article  PubMed  Google Scholar 

  26. Blenkinsop, A., Valentin, A., Richardson, M. P., et al. (2012). The dynamic evolution of focal-onset epilepsies–combining theoretical and clinical observations. European Journal of Neuroscience, 36, 2188–2200.

    Article  PubMed  Google Scholar 

  27. Akiyama, T., Chan, D. W., Go, C. Y., et al. (2011). Topographic movie of intracranial ictal high-frequency oscillations with seizure semiology: Epileptic network in Jacksonian seizures. Epilepsia, 52, 75–83.

    Article  PubMed  Google Scholar 

  28. Ochi, A., Otsubo, H., Donner, E. J., et al. (2007). Dynamic changes of ictal highfrequency oscillations in neocortical epilepsy: Using multiple band frequency analysis. Epilepsia, 48, 286–296.

    Article  PubMed  Google Scholar 

  29. Morrell, F. (1985). Secondary epileptogenesis in man. Archives of Neurology, 1985(42), 318–335.

    Article  Google Scholar 

  30. Moshe, S. L., & Shinnar, S. (1993). Early intervention. In J. J. Engel (Ed.), Surgical treatment of the epilepsies (pp. 123–132). New York: Raven Press.

    Google Scholar 

  31. Awad, I. A., Rosenfeld, J., Ahl, J., et al. (1991). Intractable epilepsy and structural lesions ofthe brain: Mapping, resection strategies, and seizure outcome. Epilepsia, 32, 179–186.

    Article  CAS  PubMed  Google Scholar 

  32. Nayel, M. H., Awad, I. A., & Luders, H. (1991). Extent of mesiobasal resection determines outcome after temporal lobectomy for intractable complex partial seizures. Neurosurgery, 29, 55–60.

    Article  CAS  PubMed  Google Scholar 

  33. Noachtar, S. (2001). Epidural electrodes. In H. Lüders & Y. Comair (Eds.), Epilepsy surgery (pp. 585–591). Philadelphia: Lippincott Williams & Wilkins.

    Google Scholar 

  34. Morrell, F., Whisler, W. W., & Bleck, T. P. (1989). Multiple subpial transection: a new approach to the surgical treatment of focal epilepsy. Journal of Neurosurgery, 70, 231.

    Article  CAS  PubMed  Google Scholar 

  35. Chadwick, D. (2001). Vagal-nerve stimulation for epilepsy. Lancet, 357, 1726–1727.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. 2nd Division, Department of Neurology, First People’s Hospital of Xuzhou, No. 19, Zhongshan North Road, Xuzhou, 221000, Jiangsu, People’s Republic of China

    Hongli Huang, Hao Zhou & Nuan Wang

Authors
  1. Hongli Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hao Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nuan Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Hao Zhou.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huang, H., Zhou, H. & Wang, N. Recent Advances in Epilepsy Management. Cell Biochem Biophys 73, 7–10 (2015). https://doi.org/10.1007/s12013-015-0603-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12013-015-0603-y

Keywords

Search

Navigation