Abstract
Primary granulocytic sarcoma (GS) is an uncommon, extramedullary proliferation of myeloid cells, occurring in the absence of antecedent myeloproliferative disorder. Breast involvement is uncommon. A diagnosis of GS portends a poor prognosis. Even with intensive chemotherapy for AML, progression to overt leukemia can be delayed for 2–3 years. We, report a 29-year-old man who presented with a painless, left breast lump. A modified radical mastectomy followed by histopathological and immunohistochemical testing confirmed a granulocytic sarcoma. There was no evidence of a concurrent leukemia. Intensive chemotherapy for acute myelogenous leukemia was instituted. Allogenic hematopoietic stem cell transplantation was successfully given. The patient remains in complete remission at follow-up. We highlight the importance of timely diagnosis of this uncommon entity with institution of intensive therapy. Early use of allogenic bone marrow transplantation in the treatment of primary GS may be warranted.
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Gartenhaus, W. S., Mir, R., Pliskin, A., Grunwald, H., Wise, L., Papantoniou, P. A., et al. (1985). Granulocytic sarcoma of the breast: Aleukemic bilateral metachronous presentation and literature review. Medical and Pediatric Oncology, 13, 22–29.
Yamauchi, K., & Yasuda, M. (2002). Comparison in treatments of nonleukemic granulocytic sarcoma: Report of two cases and a review of 72 cases in the literature. Cancer, 94, 1739–1746.
Antic, D., Elezovic, I., Milic, N., Suvajdzic, N., Vidovic, A., Perunicic, M., et al. (2013). Is there a “gold” standard treatment for patients with isolated myeloid sarcoma? Biomedicine and Pharmacotherapy, 67, 72–77.
Avni, B., & Koren-Michowitz, M. (2011). Myeloid sarcoma: Current approach and therapeutic options. Therapeutic Advances in Hematology, 2, 309–316.
Chevallier, P., Mohty, M., Lioure, B., Michel, G., Contentin, N., Deconinck, E., et al. (2008). Allogeneic hematopoietic stem-cell transplantation for myeloid sarcoma: A retrospective study from the SFGM-TC. Journal of Clinical Oncology, 26, 4940–4943.
Avni, B., Rund, D., Levin, M., Grisariu, S., Ben-Yehuda, D., Bar-Cohen, S., & Paltiel, O. (2012). Clinical implications of acute myeloid leukemia presenting as myeloid sarcoma. Hematological Oncology, 30, 34–40.
Eshghabadi, M., Shojania, A. M., & Carr, I. (1986). Isolated granulocytic sarcoma: report of a case and review of the literature. Journal of Clinical Oncology, 4, 912–917.
Valbuena, J. R., Admirand, J. H., Gualco, G., & Madeiros, L. J. (2005). Myeloid sarcoma involving the breast. Archives of Pathology and Laboratory Medicine, 129, 32–38.
Kumar, B., Bommana, V., Irani, F., Kasmani, R., Mian, A., & Mahajan, K. (2009). An uncommon cause of small bowel obstruction: Isolated primary granulocytic sarcoma. QJM, 102, 491–493.
Kowal-Vern, A., Johnson, F. L., Trujillo, Y., Nachman, J., Radhakrishnan, J., Conard, P., et al. (1991). Granulocytic sarcoma of the ileum treated by bone marrow transplantation. The American Journal of Pediatric Hematology/Oncology, 13, 34–38.
Chevallier, P., Mohty, M., Lioure, B., Michel, G., Contentin, N., Deconinck, E., et al. (2006). Allogeneic hematopoietic stem-cell transplantation for myeloid sarcoma: A retrospective study from the SFGM-TC. Leukaemia and Lymphoma, 47, 2527–2541.
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The author would like to thank Prof. Xiongzeng Zhu for help with pathology diagnosis of primary granulocytic sarcoma.
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Li, X., Fu, J., Xue, Y. et al. Allogeneic Hematopoietic Stem Cell Transplantation as Treatment for Primary Granulocytic Sarcoma of the Breast. Cell Biochem Biophys 72, 791–794 (2015). https://doi.org/10.1007/s12013-015-0534-7
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DOI: https://doi.org/10.1007/s12013-015-0534-7