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The Use of Calcium Channel Blockers in the Treatment of Coronary Spasm and Atrioventricular Block

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Abstract

Calcium channel blockers have been used in the treatment of coronary artery spasm for many years. However, there is insufficient knowledge about their application to treat atrioventricular block caused by coronary spasm. Clinical data of five patients who were diagnosed with coronary spasm caused by atrioventricular block and treated with calcium channel blockers were retrospectively assessed. The patients had varying degrees of atrioventricular block (confirmed by Holter ECG) and myocardial ischemia-like ST–T changes. Two patients were II type I AVB, two patients II type II AVB, and the remaining one patient was III AVB. All patients were all diagnosed with right coronary artery spasm by coronary angiography. The patients were treated with calcium channel blockers. No patient reported recurrence of chest pain or chest discomfort. On Holter ECG monitoring, no significant myocardial ischemia or atrioventricular block was seen. In conclusion, calcium channel blockers are effective and safe in the treatment of atrioventricular block caused by coronary spasm.

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Authors declare no conflicts of interest.

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Authors and Affiliations

  1. Suizhou Central Hospital, Affiliated Hospital of Hubei University of Medicine, Wuhan, Hubei, China

    Bo Gao, Zhenjian Zhang, Jin Qian, Chuanbin Cao, Xianping Hua & Mengting Chu

  2. Department of Cardiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Road, Wuhan, 430030, Hubei, China

    Xingwei HE & Hesong Zeng

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  1. Bo Gao
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  2. Zhenjian Zhang
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  3. Jin Qian
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  4. Chuanbin Cao
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  5. Xianping Hua
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  6. Mengting Chu
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  7. Xingwei HE
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  8. Hesong Zeng
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Correspondence to Hesong Zeng.

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Gao, B., Zhang, Z., Qian, J. et al. The Use of Calcium Channel Blockers in the Treatment of Coronary Spasm and Atrioventricular Block. Cell Biochem Biophys 72, 527–531 (2015). https://doi.org/10.1007/s12013-014-0498-z

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  • DOI: https://doi.org/10.1007/s12013-014-0498-z

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