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rs3746444 Polymorphism and Susceptibility to Hepatocellular Carcinoma: Evidence from Published Studies

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Abstract

The present study was undertaken to quantitatively evaluate the association between rs3746444 polymorphism and HCC risk. In this analysis with 667 cancer cases and 1,006 control subjects, we summarized 4 eligible case–control studies by searching databases of PubMed, EMBASE, and CNKI. The strength of the association was assessed by calculating odds ratios (ORs) with 95 % confidence intervals (CIs) with the fixed-effects model. We found that neither the allele frequency nor genotype distribution of this polymorphism was associated with risk of HCC in any genetic model. Similarly, no associations were suggested either in subgroup analyses by ethnicity or by source of control. Our research suggested that rs3746444 polymorphism may not be a risk factor for HCC. However, well-designed studies with a larger sample size are needed to confirm these findings.

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References

  1. Forner, A., Llovet, J. M., & Bruix, J. (2012). Hepatocellular carcinoma. Lancet, 379(9822), 1245–1255.

    Article  PubMed  Google Scholar 

  2. Maluccio, M., & Covey, A. (2012). Recent progress in understanding, diagnosing, and treating hepatocellular carcinoma. CA: A Cancer Journal for Clinicians, 62(6), 394–399.

    Google Scholar 

  3. Montesano, R., Hainaut, P., & Wild, C. P. (1997). Hepatocellular carcinoma: from gene to public health. c, 89(24), 1844–1851.

    CAS  Google Scholar 

  4. Bruix, J., et al. (1989). Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis. Lancet, 2(8670), 1004–1006.

    Article  CAS  PubMed  Google Scholar 

  5. Ross, R. K., et al. (1992). Urinary aflatoxin biomarkers and risk of hepatocellular carcinoma. Lancet, 339(8799), 943–946.

    Article  CAS  PubMed  Google Scholar 

  6. Marrero, J. A., et al. (2005). Alcohol, tobacco and obesity are synergistic risk factors for hepatocellular carcinoma. Journal of Hepatology, 42(2), 218–224.

    Article  CAS  PubMed  Google Scholar 

  7. Thorgeirsson, S. S., & Grisham, J. W. (2002). Molecular pathogenesis of human hepatocellular carcinoma. Nature Genetics, 31(4), 339–346.

    Article  CAS  PubMed  Google Scholar 

  8. Hagymasi, K., & Tulassay, Z. (2008). Epidemiology, risk factors and molecular pathogenesis of primary liver cancer. Orvosi Hetilap, 149(12), 541–548.

    Article  PubMed  Google Scholar 

  9. Bartel, D. P. (2004). MicroRNAs: Genomics, biogenesis, mechanism, and function. Cell, 116(2), 281–297.

    Article  CAS  PubMed  Google Scholar 

  10. Esquela-Kerscher, A., & Slack, F. J. (2006). Oncomirs—microRNAs with a role in cancer. Nature Reviews Cancer, 6(4), 259–269.

    Article  CAS  PubMed  Google Scholar 

  11. Wienholds, E., & Plasterk, R. H. (2005). MicroRNA function in animal development. FEBS Letters, 579(26), 5911–5922.

    Article  CAS  PubMed  Google Scholar 

  12. Chen, J. F., et al. (2006). The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nature Genetics, 38(2), 228–233.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  13. Brennecke, J., et al. (2003). Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell, 113(1), 25–36.

    Article  CAS  PubMed  Google Scholar 

  14. Cimmino, A., et al. (2005). MiR-15 and miR-16 induce apoptosis by targeting BCL2. Proceedings of the National Academy of Sciences, 102(39), 13944–13949.

    Article  CAS  Google Scholar 

  15. Skalsky, R. L., & Cullen, B. R. (2011). Reduced expression of brain-enriched microRNAs in glioblastomas permits targeted regulation of a cell death gene. PLoS ONE, 6(9), e24248.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  16. Hatfield, S. D., et al. (2005). Stem cell division is regulated by the microRNA pathway. Nature, 435(7044), 974–978.

    Article  CAS  PubMed  Google Scholar 

  17. Calin, G. A., et al. (2008). MiR-15a and miR-16-1 cluster functions in human leukemia. Proceedings of the National Academy of Sciences, 105(13), 5166–5171.

    Article  CAS  Google Scholar 

  18. Iorio, M. V., et al. (2005). MicroRNA gene expression deregulation in human breast cancer. Cancer Research, 65(16), 7065–7070.

    Article  CAS  PubMed  Google Scholar 

  19. Chan, J. A., Krichevsky, A. M., & Kosik, K. S. (2005). MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Research, 65(14), 6029–6033.

    Article  CAS  PubMed  Google Scholar 

  20. Zeng, Y., et al. (2010). Correlation between pre-miR-146a C/G polymorphism and gastric cancer risk in Chinese population. World Journal of Gastroenterology, 16(28), 3578–3583.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  21. Akkiz, H., et al. (2011). Genetic variation in the microRNA-499 gene and hepatocellular carcinoma risk in a Turkish population: lack of any association in a case-control study. Asian Pacific Journal of Cancer Prevention, 12(11), 3107–3112.

    PubMed  Google Scholar 

  22. Zhou, J., et al. (2012). Association between two genetic variants in miRNA and primary liver cancer risk in the Chinese population. DNA and Cell Biology, 31(4), 524–530.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Xiang, Y., et al. (2012). Association of the microRNA-499 variants with susceptibility to hepatocellular carcinoma in a Chinese population. Molecular Biology Reports, 39(6), 7019–7023.

    Article  CAS  PubMed  Google Scholar 

  24. Kim, W. H., et al. (2012). Association study of microRNA polymorphisms with hepatocellular carcinoma in Korean population. Gene, 504(1), 92–97.

    Article  CAS  PubMed  Google Scholar 

  25. Hu, M., et al. (2013). The association between two common polymorphisms in MicroRNAs and hepatocellular carcinoma risk in Asian population. PLoS ONE, 8(2), e57012.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Yin, Z., et al. (2013). Effects of common polymorphisms rs2910164 in miR-146a and rs3746444 in miR-499 on cancer susceptibility: a meta-analysis. Molecular Biology Reports, 40(4), 3003–3013.

    Article  CAS  PubMed  Google Scholar 

  27. Lau, J., Ioannidis, J. P., & Schmid, C. H. (1997). Quantitative synthesis in systematic reviews. Annals of Internal Medicine, 127(9), 820–826.

    Article  CAS  PubMed  Google Scholar 

  28. MANTEL, N., & HAENSZEL, W. (1959). Statistical aspects of the analysis of data from retrospective studies of disease. Journal of the National Cancer Institute, 22(4), 719–748.

    CAS  PubMed  Google Scholar 

  29. DerSimonian, R., & Laird, N. (1986). Meta-analysis in clinical trials. Controlled Clinical Trials, 7(3), 177–188.

    Article  CAS  PubMed  Google Scholar 

  30. Egger, M., et al. (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 315(7109), 629–634.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  31. Chen, L. T., et al. (2012). MicroRNA-378 is associated with non-small cell lung cancer brain metastasis by promoting cell migration, invasion and tumor angiogenesis. Medical Oncology, 29(3), 1673–1680.

    Article  CAS  PubMed  Google Scholar 

  32. Lu, Y., et al. (2007). Transgenic over-expression of the microRNA miR-17-92 cluster promotes proliferation and inhibits differentiation of lung epithelial progenitor cells. Development Biology, 310(2), 442–453.

    Article  CAS  Google Scholar 

  33. Yang, W., et al. (2006). Modulation of microRNA processing and expression through RNA editing by ADAR deaminases. Nature Structural and Molecular Biology, 13(1), 13–21.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of General Surgery, the First Affiliated Hospital, China Medical University, Shenyang, 110001, Liaoning Province, China

    Fangfeng Liu, Ying Cheng, Lei Yang & Yongfeng Liu

  2. Department of Hepatobiliary Surgery, People’s Hospital of Weifang, Weifang, 261041, Shandong Province, China

    Hongfeng Lin

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  1. Fangfeng Liu
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  2. Hongfeng Lin
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  3. Ying Cheng
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  4. Lei Yang
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Correspondence to Yongfeng Liu.

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Fangfeng Liu and Hongfeng Lin are Co-first authors.

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Liu, F., Lin, H., Cheng, Y. et al. rs3746444 Polymorphism and Susceptibility to Hepatocellular Carcinoma: Evidence from Published Studies. Cell Biochem Biophys 70, 1957–1961 (2014). https://doi.org/10.1007/s12013-014-0156-5

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