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Study on the Effect of Kidney Transplantation on the Health of the Patients’ Offspring: A Report on 252 Chinese Children

  • Translational Biomedical Research
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Abstract

Even though the incidence of pregnancies in the female recipients is lower and also chronic renal disease in male patients is associated with impaired spermatogenesis, the health of the children born to these patients was not studied. In this report, we discuss information on the growth and development of offspring of 248 male and female kidney recipient patients. Physical and routine clinical measurements of the 252 offspring (129 male and 123 female) born to these transplantation patients were made along with the intelligence tests. In some of these children chest X-ray and immune indices were assessed. Among the recipients, 219 males fathered 223 children with an average birth weight of 3,255 ± 374 g and 29 female recipients gave birth to 29 children with an average birth weight of 2,923 ± 551. While most of these children were normal, we noticed a case of soft double toe, a case of short tongue tie, five cases of marginal mental retardation, three cases of proteinuria, six cases of microscopic hematuria, 15 cases of low hemoglobin, and 21 cases with recurrent respiratory tract infections. We conclude that kidney transplantation has no significant impact on the growth, development, health, and intelligence of the offspring born to recipients.

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Abbreviations

Aza:

Azathioprine

CsA:

Cyclosporine A

Pred:

Prednisone

FK506:

Tacrolimus

MMF:

Mycophenolate mofetil

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Acknowledgments

We acknowledge the support from Scientific and technological research projects in Zhejiang Province (2010C33084) Medical and health research projects in Zhejiang Province (2009A182) Hangzhou Science and Technology Research Fund (20090833B22).

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Authors and Affiliations

  1. Kidney Transplant Center, Jiulisong Hospital, Hangzhou, 310013, China

    Longgen Xu & Xiaofeng Zhu

  2. Institute of Organ Transplantation, Changzheng Hospital, Shanghai, China

    Peng Han & Youhua Zhu

  3. Department of Urologic Transplantation, The First People Hospital, Shanghai Jiaotong University, Shanghai, China

    Yong Liu

  4. Department of Kidney Transplantation, The Second Hospital, Shandong University, Jinan, China

    Hongwei Wang

  5. Transplantation Center, The First Hospital of Wenzhou Medical University, Wenzhou, China

    Yirong Yang & Jing Fu

  6. Department of Transplantation, Renji Hospital, Medical College, Shanghai Jiaotong University, Shanghai, China

    Feng Qiu

  7. Department of Urology, 153 Center Hospital, Zhengzhou, Henan, China

    Wanling Peng

  8. Department of Urology, Wuhan General Hospital, Wuhan, China

    Ligong Tang

Authors
  1. Longgen Xu
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  2. Peng Han
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  3. Yong Liu
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  4. Hongwei Wang
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  5. Yirong Yang
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  6. Feng Qiu
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  7. Wanling Peng
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  8. Ligong Tang
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  9. Jing Fu
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  10. Xiaofeng Zhu
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  11. Youhua Zhu
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Corresponding authors

Correspondence to Longgen Xu or Youhua Zhu.

Additional information

Longgen Xu and Peng Han are co-first authors.

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Xu, L., Han, P., Liu, Y. et al. Study on the Effect of Kidney Transplantation on the Health of the Patients’ Offspring: A Report on 252 Chinese Children. Cell Biochem Biophys 68, 173–179 (2014). https://doi.org/10.1007/s12013-013-9685-6

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  • DOI: https://doi.org/10.1007/s12013-013-9685-6

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