Abstract
Crataegus sanguinea is a wild plant, which has been widely grown in the north and south of the Tianshan mountains in Xinjiang. In order to explore their anti-cancer properties, edible wild plants from Xinjiang have been tested for their antitumor properties. We used Ames tests, mouse bone marrow polychromatic erythrocytes micronucleus tests, and tumor cells cultured in vitro to study the anti-mutagenic and anti-tumor effects of C. sanguinea extract. We have shown that C. sanguinea has anti-mutagenic effect, but no mutagenicity. Cell culture in vitro experiments show that there is no inhibition of growth or increase in cell death on normal mouse fibroblasts, but a stronger inhibition of cell growth and an increase in cell death of Hep-2 and MGC-803 tumor cells. The results of this study illustrate that C. sanguinea extract has both anti-mutagenic and anti-tumor effects.
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The authors acknowledge Prof. Chaolun Chen (Pathological department, the First Affiliated Hospital of Xinjiang Medical University), and also Nutrition and Cancer Department team for providing experimental facilities.
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Jianling Sun and Guolan Gao contributed equally to this study.
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Sun, J., Gao, G., Gao, Y. et al. Experimental Research on the In Vitro Antitumor Effects of Crataegus sanguinea . Cell Biochem Biophys 67, 207–213 (2013). https://doi.org/10.1007/s12013-013-9535-6
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DOI: https://doi.org/10.1007/s12013-013-9535-6