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Association of Plasma Selenium and Its Untargeted Metabolomic Profiling with Cervical Cancer Prognosis

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Abstract

Selenium is an essential trace element that shows beneficial or adverse health effects depending on the dose. However, its role in the prognosis of cervical cancer (CC) has been less reported. We aimed to explore the association between selenium status and prognosis in CC patients with different prognoses and to elucidate the underlying mechanism of selenium in CC prognosis. This cross-sectional observational study had a case–control design at the Harbin Medical University Cancer Hospital and was conducted using 29 CC cases with poor prognosis and 29 CC cases with good prognosis. Plasma selenium levels were measured using an atomic fluorescence spectrometer. Untargeted metabolomics was used to identify metabolites. Plasma selenium levels of the poor prognosis group (49.90 ± 13.81 µg/L) were lower than that of the good prognosis group (59.38 ± 13.00 µg/L, t = 2.69, P = 0.009). In the logistic regression analysis, plasma selenium levels were associated with lower poor prognosis risk [odds ratio (OR) = 0.952, 95% CI: 0.909–0.998]. Receiver operating characteristic curve analysis revealed an optimal cut-off point of plasma selenium levels ≤ 47.68 µg/L for poor prognosis of CC. Based on the cut-off selenium levels, patients with different prognoses were divided into high and low selenium groups. Metabolomic analysis revealed six differential metabolites among different prognoses with low and high selenium levels, and the glycerophospholipid (GPL) metabolism was enriched. Plasma selenium levels were positively correlated with metabolite levels. Our findings provided evidence that low plasma selenium levels may associate with a poor prognosis of CC. Low plasma selenium levels might suppress GPL metabolism and influence the prognosis of CC. This finding requires confirmation in future prospective cohort studies.

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Acknowledgements

We sincerely thank all the patients for participating in this study. We are grateful to Shanghai LuMing Biological Technology for metabolomics analysis and data interpretation.

Funding

This work was supported by the Postdoctoral Scientific Research Developmental Fund of Heilongjiang Province (LBH-Q17096), and the Haiyan Foundation of Harbin Medical University Cancer Hospital (JJZD2021-16). The National Natural Science Foundation of China (No. 81773368). Talent Training Fund of 2019 Qiqihar Municipal Leading Talents Echelon.

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  1. Lei Qi and Yuanyuan Wang contributed equally to this work

Authors and Affiliations

  1. Institute of Keshan Disease, Chinese Center for Endemic Disease Control, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China

    Lei Qi, Yuanyuan Wang, Ruixiang Wang, Shengqi Su, Yuehui Jia & Tong Wang

  2. School of Public Health, Qiqihar Medical University, Qiqihar, 161006, Heilongjiang, China

    Lei Qi

  3. Department of Gynecological Radiotherapy, Harbin Medical University Cancer Hospital, 150 Haping Road, Harbin, 150081, China

    Mingxing Wang & Qi Li

  4. Department of Translational Research, Nofer Institute of Occupational Medicine, Sw. Teresy 8 Street, 91-348, Lodz, Poland

    Ewa Jablonska

  5. Department of Public Health, Jining Medical University, Jining, 272029, China

    Huihui Zhou

  6. Yantai Center for Disease Control and Prevention, No.17 Fuhou Road, Laishan District, Yantai, 264003, China

    Yiyi Zhang

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Contributions

Conception and design: QL, TW; Administrative support: EJ, QL, TW; Provision of study materials or patients: LQ, MW, HZ, YZ; Collection and assembly of data: LQ, HZ, YW, SS; Data analysis and interpretation: LQ, YW, YJ, RW; Manuscript writing: All authors; Final approval of manuscript: All authors.

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Correspondence to Qi Li or Tong Wang.

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Qi, L., Wang, Y., Wang, R. et al. Association of Plasma Selenium and Its Untargeted Metabolomic Profiling with Cervical Cancer Prognosis. Biol Trace Elem Res 201, 4637–4648 (2023). https://doi.org/10.1007/s12011-022-03552-5

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