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Prevalence of Components of Metabolic Syndrome Among Adults with the Presence of Autoimmune Thyroid Condition in an Iodine-Sufficient Region

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Abstract

The presence of autoimmune thyroid condition could lead to thyroid dysfunction in adults. In addition, thyroid antibody positivity has been suggested to be associated with hyperuricemia, diabetes and obesity in individuals with thyroid autoimmune diseases. Currently, there are limited studies that assessed the relationship of thyroid antibody with the components of metabolic syndrome in adults, especially from iodine-sufficient regions. Therefore, the aim of this study was to determine the prevalence of components of metabolic syndrome in Chinese adults with autoimmune thyroid condition. Medical records of adult inpatients in the Suzhou Ninth People’s Hospital, Suzhou, Jiangsu, China, from January 2016 to September 2019 were reviewed and included after screening for eligibility. A total of 1105 participants were included in our final analysis, and of these, 77.5% (n = 856) were females. There was a higher prevalence of thyroid antibodies in females than males (30.6% vs. 23.7%) (p = 0.034). Although there were significant differences in mean TSH, FT3 and FT4 values between participants positive and negative for thyroid antibodies, these values were still within the normal reference range. No differences in the mean BMI, prevalence of diabetes, hyperuricemia, hypertriglyceridemia and hypercholesterolemia between participants positive and negative for thyroid antibodies were reported (p > 0.05). In conclusion, our study reported that participants positive for thyroid antibodies did not appear to be accompanied by abnormal thyroid function, lipid profile, uric acid and glucose concentrations.

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References

  1. Li Y, Zhao L, Yu D, Wang Z, Ding G (2018) Metabolic syndrome prevalence and its risk factors among adults in China: a nationally representative cross-sectional study. PloS One 13(6):e0199293–e0199293. https://doi.org/10.1371/journal.pone.0199293

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Duntas LH, Orgiazzi J, Brabant G (2011) The interface between thyroid and diabetes mellitus. Clin Endocrinol (Oxf) 75(1):1–9. https://doi.org/10.1111/j.1365-2265.2011.04029.x

    Article  CAS  Google Scholar 

  3. Giordano N, Santacroce C, Mattii G, Geraci S, Amendola A, Gennari C (2001) Hyperuricemia and gout in thyroid endocrine disorders. Clin Exp Rheumatol 19(6):661–666

    CAS  PubMed  Google Scholar 

  4. Huang J, Ma ZF, Tian Y, Lee YY (2020) Epidemiology and prevalence of gout in mainland China: an updated systematic review and meta-analysis. SN Compr Clin Med. 2:1593–1606. https://doi.org/10.1007/s42399-020-00416-8

    Article  Google Scholar 

  5. McLeod DS, Cooper DS (2012) The incidence and prevalence of thyroid autoimmunity. Endocrine 42(2):252–265

    Article  CAS  Google Scholar 

  6. Simmonds MJ, Gough SC (2004) Unravelling the genetic complexity of autoimmune thyroid disease: HLA, CTLA-4 and beyond. Clin Exp Immunol 136(1):1–10. https://doi.org/10.1111/j.1365-2249.2004.02424.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Topliss DJ (2016) Clinical update in aspects of the management of autoimmune thyroid diseases. Endocrinol Metab 31(4):493–499. https://doi.org/10.3803/EnM.2016.31.4.493

    Article  CAS  Google Scholar 

  8. Stathatos N, Daniels GH (2012) Autoimmune thyroid disease. Curr Opin Rheumatol 24(1):70–75. https://doi.org/10.1097/BOR.0b013e32834ddb27

    Article  CAS  PubMed  Google Scholar 

  9. Caturegli P, Kuppers RC, Mariotti S, Burek CL, Pinchera A, Ladenson PW, Rose NR (1994) IgG subclass distribution of thyroglobulin antibodies in patients with thyroid disease. Clin Exp Immunol 98(3):464–469. https://doi.org/10.1111/j.1365-2249.1994.tb05514.x

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Agate L, Lorusso L, Piaggi P, Bianchi F, Brozzi F, Santini P, Molinaro E, Vitti P, Elisei R (2016) Role of thyroglobulin, neck ultrasound, thyroglobulin antibodies trend and diagnostic whole body scan in the management of differentiated thyroid cancer patients with persistent thyroglobulin antibodies. J Nucl Med Radiat Ther 7(317):2

    Google Scholar 

  11. Weetman AP (2004) Autoimmune thyroid disease. Autoimmunity 37(4):337–340. https://doi.org/10.1080/08916930410001705394

    Article  CAS  PubMed  Google Scholar 

  12. Soy M, Guldiken S, Arikan E, Altun BU, Tugrul A (2007) Frequency of rheumatic diseases in patients with autoimmune thyroid disease. Rheumatol Int 27(6):575–577. https://doi.org/10.1007/s00296-006-0263-8

    Article  PubMed  Google Scholar 

  13. Fröhlich E, Wahl R (2017) Thyroid autoimmunity: role of anti-thyroid antibodies in thyroid and extra-thyroidal diseases. Front Immunol 8:521–521. https://doi.org/10.3389/fimmu.2017.00521

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Marqusee E, Hill JA, Mandel SJ (1997) Thyroiditis after pregnancy loss. J Clin Endocrinol Metab 82(8):2455–2457. https://doi.org/10.1210/jcem.82.8.4168

    Article  CAS  PubMed  Google Scholar 

  15. Taylor PN, Albrecht D, Scholz A, Gutierrez-Buey G, Lazarus JH, Dayan CM, Okosieme OE (2018) Global epidemiology of hyperthyroidism and hypothyroidism. Nat Rev Endocrinol 14(5):301–316. https://doi.org/10.1038/nrendo.2018.18

    Article  PubMed  Google Scholar 

  16. Zhou H, Ma ZF, Lu Y, Pan B, Shao J, Wang L, Du Y, Zhao Q (2019) Assessment of iodine status among pregnant women and neonates using neonatal thyrotropin (TSH) in mainland China after the introduction of new revised universal salt iodisation (USI) in 2012: a re-emergence of iodine deficiency? Int J Endocrinol 2019:3618169–3618167. https://doi.org/10.1155/2019/3618169

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Zhou H, Lu Y, Pan B, Zhao Q, Ma ZF (2020) Iodine deficiency as assessed by neonatal tsh in a sample of mother-and-newborn pairs in Jiangsu Province, China. Biol Trace Elem Res. https://doi.org/10.1007/s12011-12020-02135-12016

  18. Lazarus J, Premawardhana L (2005) Screening for thyroid disease in pregnancy. J Clin Pathol 58(5):449–452

    Article  CAS  Google Scholar 

  19. Zhou BF (2002) Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci 15(1):83–96

    PubMed  Google Scholar 

  20. Ma ZF, Venn BJ, Manning PJ, Cameron CM, Skeaff SA (2016) Iodine supplementation of mildly iodine-deficient adults lowers thyroglobulin: a randomized controlled trial. J Clin Endocrinol Metab 101(4):1737–1744. https://doi.org/10.1210/jc.2015-3591

    Article  CAS  PubMed  Google Scholar 

  21. Ma ZF, Venn BJ, Manning PJ, Cameron CM, Skeaff SA (2018) The sensitivity and specificity of thyroglobulin concentration using repeated measures of urinary iodine excretion. Eur J Nutr 57(4):1313–1320. https://doi.org/10.1007/s00394-017-1410-6

    Article  CAS  PubMed  Google Scholar 

  22. Bjoro T, Holmen J, Kruger O, Midthjell K, Hunstad K, Schreiner T, Sandnes L, Brochmann H (2000) Prevalence of thyroid disease, thyroid dysfunction and thyroid peroxidase antibodies in a large, unselected population. The Health Study of Nord-Trondelag (HUNT). Eur J Endocrinol 143(5):639–647

    Article  CAS  Google Scholar 

  23. Tipu HN, Ahmed D, Bashir MM, Asif N (2018) Significance of testing anti-thyroid autoantibodies in patients with deranged thyroid profile. J Thyroid Res 2018:9610497. https://doi.org/10.1155/2018/9610497

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Diab N, Daya NR, Juraschek SP, Martin SS, McEvoy JW, Schultheiß UT, Köttgen A, Selvin E (2019) Prevalence and risk factors of thyroid dysfunction in older adults in the community. Sci Rep 9(1):13156. https://doi.org/10.1038/s41598-019-49540-z

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Knudsen N, Jorgensen T, Rasmussen S, Christiansen E, Perrild H (1999) The prevalence of thyroid dysfunction in a population with borderline iodine deficiency. Clin Endocrinol (Oxf) 51(3):361–367. https://doi.org/10.1046/j.1365-2265.1999.00816.x

    Article  CAS  Google Scholar 

  26. Ma ZF (2018) Thyrotoxicosis after iodine fortification. A 21-year Danish population-based study. Clin Endocrinol 89(5):677–678

    Article  Google Scholar 

  27. Pedersen IB, Knudsen N, Carle A, Vejbjerg P, Jorgensen T, Perrild H, Ovesen L, Rasmussen LB, Laurberg P (2011) A cautious iodization programme bringing iodine intake to a low recommended level is associated with an increase in the prevalence of thyroid autoantibodies in the population. Clin Endocrinol (Oxf) 75(1):120–126. https://doi.org/10.1111/j.1365-2265.2011.04008.x

    Article  CAS  Google Scholar 

  28. Pedersen IB, Laurberg P, Knudsen N, Jorgensen T, Perrild H, Ovesen L, Rasmussen LB (2008) Smoking is negatively associated with the presence of thyroglobulin autoantibody and to a lesser degree with thyroid peroxidase autoantibody in serum: a population study. Eur J Endocrinol 158(3):367–373. https://doi.org/10.1530/eje-07-0595

    Article  CAS  PubMed  Google Scholar 

  29. Zhang Y, Shi L, Zhang Q, Peng N, Chen L, Lian X, Liu C, Shan Z, Shi B, Tong N, Wang S, Weng J, Zhao J, Teng W (2019) The association between cigarette smoking and serum thyroid stimulating hormone, thyroid peroxidase antibodies and thyroglobulin antibodies levels in Chinese residents: a cross-sectional study in 10 cities. PLoS One 14(11):e0225435. https://doi.org/10.1371/journal.pone.0225435

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Jia M, Shi X, Gu X, Guan H, Teng X, Teng D, Fan C, Li Y, Shan Z, Teng W, Li Y (2019) Smoking is positively associated with antithyroperoxidase antibodies and antithyroglobulin antibodies in populations with mildly deficient iodine intake. Biol Trace Elem Res 187(2):383–391. https://doi.org/10.1007/s12011-018-1410-2

    Article  CAS  PubMed  Google Scholar 

  31. Choi YM, Kim TY, Kim EY, Jang EK, Jeon MJ, Kim WG, Shong YK, Kim WB (2017) Association between thyroid autoimmunity and Helicobacter pylori infection. Korean J Intern Med 32(2):309–313. https://doi.org/10.3904/kjim.2014.369

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Fernandez Martinez P, Aguado Garcia R, Barajas Galindo DE, Hernandez Moreno A, Alejo Ramos M, Garcia Arias S, Ballesteros Pomar MD, Cano Rodriguez IM (2018) Influence of thyroid peroxidase antibodies on TSH levels of pregnant women and maternal-fetal complications. Endocrinol Diabetes Nutr 65(8):444–450. https://doi.org/10.1016/j.endinu.2018.05.004

    Article  Google Scholar 

  33. Li Y, Chen DN, Cui J, Xin Z, Yang GR, Niu MJ, Yang JK (2016) Using Hashimoto thyroiditis as gold standard to determine the upper limit value of thyroid stimulating hormone in a Chinese cohort. BMC Endocr Disord 16(1):57. https://doi.org/10.1186/s12902-016-0137-3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Tamer G, Mert M, Tamer I, Mesci B, Kilic D, Arik S (2011) Effects of thyroid autoimmunity on abdominal obesity and hyperlipidaemia. Endokrynol Pol 62(5):421–428

    CAS  PubMed  Google Scholar 

  35. Raposo L, Martins S, Ferreira D, Guimarães JT, Santos AC (2019) Metabolic syndrome, thyroid function and autoimmunity - the PORMETS study. Endocr Metab Immune Disord Drug Targets 19(1):75–83. https://doi.org/10.2174/1871530318666180801125258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Amouzegar A, Kazemian E, Abdi H, Gharibzadeh S, Tohidi M, Azizi F (2020) Abdominal obesity phenotypes and incidence of thyroid autoimmunity: a 9-year follow-up. Endocr Res. https://doi.org/10.1080/07435800.2020.1749847

  37. Ren R, Ma Y, Deng F, Li T, Wang H, Wei J, Jiang X, He M, Tian M, Liu D, Chen B, Deng W (2019) Association between serum TSH levels and metabolic components in euthyroid subjects: a nationwide population-based study. Diabetes Metab Syndr Obes 12:1563–1569. https://doi.org/10.2147/dmso.S202769

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

We express our sincere thanks to all participants in our study.

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Authors and Affiliations

  1. Department of Clinical Nutrition, Suzhou Ninth People’s Hospital, Suzhou, 215200, Jiangsu Province, China

    Binyu Pan & Qin Zhang

  2. Clinical Medical College, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China

    Hang Zhou

  3. Department of Clinical Nutrition, Northern Jiangsu People’s Hospital, Yangzhou, 225001, Jiangsu Province, China

    Hang Zhou

  4. Department of Health and Environmental Sciences, Xi’an Jiaotong-Liverpool University, Suzhou, 215123, Jiangsu Province, China

    Zheng Feei Ma

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  1. Binyu Pan
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Correspondence to Zheng Feei Ma.

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All procedures performed in the retrospective study involving human participants were in accordance with the ethical standards of the Ethics Committee of the Northern Jiangsu People’s Hospital (reference no. 2018063) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Pan, B., Zhang, Q., Zhou, H. et al. Prevalence of Components of Metabolic Syndrome Among Adults with the Presence of Autoimmune Thyroid Condition in an Iodine-Sufficient Region. Biol Trace Elem Res 199, 2837–2843 (2021). https://doi.org/10.1007/s12011-020-02413-3

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  • DOI: https://doi.org/10.1007/s12011-020-02413-3

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