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Selenium Supplementation Protects Against Lipopolysaccharide-Induced Heart Injury via Sting Pathway in Mice

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Abstract

Sepsis-induced myocardial dysfunctions are associated with high morbidity and mortality. Selenium, an essential trace element, has been reported to exert anti-inflammation, anti-oxidative stress, and anti-apoptosis. However, the protective effects of selenium on LPS-induced heart injury are still poorly illustrated. Therefore, in the present study, we sought to explore the effects of selenium pretreatment on LPS-induced myocardial injury in mice. We firstly found that selenium pretreatment significantly improved markers of myocardial injury and alleviated LPS-induced myocardial dysfunctions. Moreover, selenium supplementation reduced pro-inflammatory cytokines expression, decreased oxidative stress, and inhibited myocardial apoptosis. In addition, selenium supplementation inactivated the Sting pathway. In conclusion, our study suggests that selenium exerts protective effects on LPS-induced myocardial injury, and the underlying molecular mechanism may be related to the inactivation of Sting pathway, implying a potential therapy for sepsis-induced myocardial dysfunctions.

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Funding

This work was supported by the China National Natural Science Foundation (81900275), the Natural Science Foundation of Shanxi Province (201801D221273), the Scientific and Technological Innovation Program of Shanxi Higher Education Institution (201804026), and the Shanxi Provincial Commission of Health and Family Planning (2017053).

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  1. Department of Cardiology, The Second Hospital of Shanxi Medical University, No. 382 Wuyi Road, Taiyuan, 030001, China

    Xuan Wang, Bin Yang, Hui-Li Cao, Rui-Ying Wang, Zhao-Yang Lu, Rui-Fang Chi & Bao Li

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  1. Xuan Wang
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Correspondence to Bao Li.

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Wang, X., Yang, B., Cao, HL. et al. Selenium Supplementation Protects Against Lipopolysaccharide-Induced Heart Injury via Sting Pathway in Mice. Biol Trace Elem Res 199, 1885–1892 (2021). https://doi.org/10.1007/s12011-020-02295-5

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